Control System for the LEDA 6.7-MeV Proton Beam Halo Experiment

Measurement of high-power proton beam-halo formation is the ongoing scientific experiment for the Low Energy Demonstration Accelerator (LEDA) facility. To attain this measurement goal, a 52-magnet beam line containing several types of beam diagnostic instrumentation is being installed. The Experimental Physics and Industrial Control System (EPICS) and commercial software applications are presently being integrated to provide a real-time, synchronous data acquisition and control system. This system is comprised of magnet control, vacuum control, motor control, data acquisition, and data analysis. Unique requirements led to the development and integration of customized software and hardware. EPICS real-time databases, Interactive Data Language (IDL) programs, LabVIEW Virtual Instruments (VI), and State Notation Language (SNL) sequences are hosted on VXI, PC, and UNIX-based platforms which interact using the EPICS Channel Access (CA) communication protocol. Acquisition and control hardware technology ranges from DSP-based diagnostic instrumentation to the PLC-controlled vacuum system. This paper describes the control system hardware and software design, and implementation.Comment: LINAC2000 Conference, 4 pg

Identifying Management of Technology and innovation (MOT) and Technology Entrepreneurship (TE) centers of excellence

It has been over 15 years since the world's centers of research excellence in the management of technology and innovation (MOT) have been acknowledged. We have updated this area of interest through a new study on the current centers of excellence, furthering our investigation in the sub-field of technology entrepreneurship (TE). We based our study on the boundary conditions utilized in previous research, adding new metrics while retaining several of the old. We limited our data sample to peer-reviewed journal articles in recognized base journals. The centers’ research nature and quality were assessed via a series of 37 metrics. We found 809 schools with publications in MOT-recognized base journals and identified 77 non-U.S. centers in Asia, Australia, Europe, South and North America and 21 U.S. centers that meet our criteria for research excellence. Further, a detailed analysis was conducted for the 21 U.S.-based schools, considering metrics such as the number of publications by researchers during the study period, the MOT publication history, editorships of the professors of the centers in the base journals, and number of articles. Similarly, we identified 17 International centers of TE excellence out of the 348 schools that published in TE. We provide tiered results of the top schools excelling in selected areas

Deactivation study of Ru-Sn-B/Al2O3 catalysts during selective hydrogenation of methyl oleate to fatty alcohol

In this work, the deactivation of the Ru-Sn-B/Al2O3 catalyst prepared by the incipient wetness method in the selective hydrogenation reaction of methyl oleate to fatty alcohol was studied. There was a decrease in both the activity and selectivity of fatty alcohol during successive reaction experiments. The fresh and deactivated catalysts were evaluated by different techniques such as TPR, XPS, TGA, Raman, and FTIR to determine the deactivation causes. Lower Ru and Sn content were found in the deactivated catalyst due to the loss of the active material during hydrogenation reaction. As the metal loss was more important for Ru than for Sn, the Ru/Sn ratio was changed, leading to a decrease of the selectivity. Moreover, the analysis of the XPS peak by the deconvolution of Sn species suggests the more active (SnOx) species for selective hydrogenation are more affected than the less selective (SnOy). Coke deposition was not observed by Raman and FTIR.Fil: Sánchez, María A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; ArgentinaFil: Vicerich, Maria Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; ArgentinaFil: Mazzieri, Vanina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; ArgentinaFil: Gioria, Esteban Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; ArgentinaFil: Gutierrez, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; ArgentinaFil: Pieck, Carlos Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; Argentin

Oxaliplatin-DNA adduct formation in white blood cells of cancer patients

In this study, we investigated the kinetics of oxaliplatin-DNA adduct formation in white blood cells of cancer patients in relation to efficacy as well as oxaliplatin-associated neurotoxicity. Thirty-seven patients with various solid tumours received 130 mg m−2 oxaliplatin as a 2-h infusion. Oxaliplatin-DNA adduct levels were measured in the first cycle using adsorptive stripping voltammetry. Platinum concentrations were measured in ultrafiltrate and plasma using a validated flameless atomic absorption spectrometry method. DNA adduct levels showed a characteristic time course, but were not correlated to platinum pharmacokinetics and varied considerably among individuals. In patients showing tumour response, adduct levels after 24 and 48 h were significantly higher than in nonresponders. Oxaliplatin-induced neurotoxicity was more pronounced but was not significantly different in patients with high adduct levels. The potential of oxaliplatin-DNA adduct measurements as pharmacodynamic end point should be further investigated in future trials

Big data and multiple methods for mapping small reservoirs: comparing accuracies for applications in agricultural landscapes

Whether or not reservoirs contain water throughout the dry season is critical to avoiding late season crop failure in seasonally-arid agricultural landscapes. Locations, volumes, and temporal dynamics, particularly of small (<1 Mm3) reservoirs are poorly documented globally, thus making it difficult to identify geographic and intra-annual gaps in reservoir water availability. Yet, small reservoirs are the most vulnerable to drying out and often service the poorest of farmers. Using the transboundary Volta River Basin (~413,000 sq km) in West Africa as a case study, we present a novel method to map reservoirs and quantify the uncertainty of Landsat derived reservoir area estimates, which can be readily applied anywhere in the globe. We applied our method to compare the accuracy of reservoir areas that are derived from the Global Surface Water Monthly Water History (GSW) dataset to those that are derived when surface water is classified on Landsat 8 OLI imagery using the Normalised Difference Water Index (NDWI), Modified NDWI with band 6 (MNDWI1), and Modified NDWI with band 7 (MNDWI2). We quantified how the areal accuracies of reservoir size estimates vary with the water classification method, reservoir properties, and environmental context, and assessed the options and limitations of using uncertain reservoir area estimates to monitor reservoir dynamics in an agricultural context. Results show that reservoir area estimates that are derived from the GSW data are 19% less accurate for our study site than MNDWI1 derived estimates, for a sample of 272 reservoir extents of 0.09 to 72 ha. The accuracy of Landsat-derived estimates improves with reservoir size and perimeter-area ratio, while accuracy may decline as surface vegetation increases. We show that GSW derived reservoir area estimates can provide an upper limit for current reservoir capacity and seasonal dynamics of larger reservoirs. Data gaps and uncertainties make GSW derived reservoir extents unsuitable for monitoring reservoirs that are smaller than 5.1 ha (holding ~49,759 m3), which constitute 674 (56%) reservoirs in the Volta basin, or monitoring seasonal fluctuations of most small reservoirs, limiting its utility for agricultural planning. This study is one of the first to test the utility and limitations of the newly available GSW dataset and provides guidance on the conditions under which this, and other Landsat-based surface water maps, can be reliably used to monitor reservoir resources

Oxaliplatin-DNA adduct formation in white blood cells of cancer patients

In this study, we investigated the kinetics of oxaliplatin-DNA adduct formation in white blood cells of cancer patients in relation to efficacy as well as oxaliplatin-associated neurotoxicity. Thirty-seven patients with various solid tumours received 130 mg m−2 oxaliplatin as a 2-h infusion. Oxaliplatin-DNA adduct levels were measured in the first cycle using adsorptive stripping voltammetry. Platinum concentrations were measured in ultrafiltrate and plasma using a validated flameless atomic absorption spectrometry method. DNA adduct levels showed a characteristic time course, but were not correlated to platinum pharmacokinetics and varied considerably among individuals. In patients showing tumour response, adduct levels after 24 and 48 h were significantly higher than in nonresponders. Oxaliplatin-induced neurotoxicity was more pronounced but was not significantly different in patients with high adduct levels. The potential of oxaliplatin-DNA adduct measurements as pharmacodynamic end point should be further investigated in future trials

Supercritical fractionation: Experimental data and modelling

International audienceno abstrac

Microalgae: Supercritical extraction and fractionation for health and energy applications

International audienceno abstrac

Translocations of the critically endangered spiny daisy in the Mid-north of South Australia

Andy Sharp, Amber Clarke, Manfred Jusaitis, Anthony Pieck, Paul Slattery & David Potterhttp://www.iucnsscrsg.org/index.php?option=com_content&view=article&id=192&Itemid=58

Supercritical Fractionation: Experimental Measurements and Modeling

International audienceno abstrac