Telesis 2021

Front Matter: This edition of Telesis, the University of Oklahoma Gibbs College of Architecture student journal, explores the theme of "Isolation."Editorial: The Telesis Team introduces Telesis: Isolation.Association: Randall Kinnaman shares his childhood experiences of visiting his incarcerated father at various prison visitation centers.Disorientation: Giuliana Vaccarino Gearty explores the positive outcomes from feeling lost in a city.Dismantling: Travis Howell and Tanner Pickens share the history of Oklahoma City’s Deep Deuce and Interstate 235.Engagement: Kate O’Connor introduces Marywood University’s Socially Responsible Architecture seminar.Food Fight: Rebecca Doglas combats food deserts.Drops: Ian Goodale provides shelter to the homeless.Displacement: Ben Gravel provides shelter for those displaced by California Wildfires.Schematics: Ryan Godfrey proposes inclusive design schematics for people with autism.Villa: Candelaria Mas Pohmajevic examines COVID 19 outbreaks in Argentina’s Shanty Towns.Rehabilitation: David Swaby investigates prison rehabilitation in the form of educational programs.Chair: Jake Lange explores the importance of agency in processes of rehabilitation.Incarceration: Emily Hays calls designers to no longer be complicit in the design of carceral facilities.Tunnel: Johanna Hilmes explores the benefits of incorporating color in prison design.Interview: Alex Finklestein interviews Dr. Jae James regarding his experience of incarceration and resultant ambitions.N

Nicotine, Neural Plasticity, and Nicotine’s Therapeutic Potential

This review is a brief summary of the effects of nicotine on neural plasticity and behavior, with a focus on the preclinical literature and the effects of nicotine on neurotrophic factors. Focus areas include underlying mechanisms of nicotine addiction and the therapeutic potential for nicotine and nicotinic receptor agonists in Parkinson’s disease, Alzheimer’s disease, traumatic brain injury, as well as cutting across these different areas of research with a brief review of the antiinflammatory effects of nicotine. It is clear that agonists at nicotinic receptors have therapeutic potential, but this should be weighed in the context of the effects of nicotine across the brain and its enhancement of neurotrophic factors. Although nicotine may have neuroprotective properties, it is important to keep in mind that these same effects underlie its addictive characteristics