Implementation of Innovative Methods for the Digital Manufacturing of Architectural Models

Various methods of Digital Manufacturing (DM) have been available for the manufacturing of physical architectural models for several years. This paper highlights the advantages of 3D printing for digital manufacturing of detailed architectural models. In particular, the representation of architectural details and textures is treated. Furthermore, two new methods are being developed in order to improve the conditions for the application of digital manufacturing of architectural models

Investigation of bio-based and recycled printing materials for additive manufacturing

Additive manufacturing (AM) processes are becoming increasingly important alongside conventional processes. As a result, the consumption of materials is also increasing. The most widespread process in polymer AM is Fused Layer Modelling (FLM). Today, the FDM process often uses synthetically produced materials based on petrochemical processes. However, there is little knowledge about which bio-based and recycled polymer materials are suitable for sustainable polymer AM. The aim of this paper is to carry out investigations of eight selected materials, which are already commercially available, to gain insights into their suitability as materials for polymer AM. These materials are divided into four categories: conventional, recycled, bio-based and fibre-reinforced thermoplastics. The evaluation model consists of a point system in which the materials are evaluated according to various weighted criteria. For technical, economic and ecological evaluation meaningful criterions were developed and applied. Based on the evaluations, three two-dimensional strength diagrams were developed, from which the results of the materials, on two of the evaluations in each case, can be read. These results are combined in a three-dimensional diagram. This representation provides the ability to make a precise selection of bio-based or recycled materials for polymer AM

HOMELETTE: a unified interface to homology modelling software

Summary: Homology modelling, the technique of generating models of 3D protein structures based on experimental structures from related proteins, has become increasingly popular over the years. An abundance of different tools for model generation and model evaluation is available from various research groups. We present HOMELETTE, an interface which implements a unified programmatic access to these tools. This allows for the assemble of custom pipelines from pre- or self-implemented building blocks. Availability and implementation: HOMELETTE is implemented in Python, compatible with version 3.6 and newer. It is distributed under the MIT license. Documentation and tutorials are available at Read the Docs (https://homelette.readthedocs.io/). The latest version of HOMELETTE is available on PyPI (https://pypi.org/project/homelette/) and GitHub (https://github.com/PhilippJunk/homelette). A full installation of the latest version of HOMELETTE with all dependencies is also available as a Docker container (https://hub.docker.com/r/philippjunk/homelette_template). Supplementary information: Supplementary data are available at Bioinformatics online

Engineering of Biological Pathways: Complex Formation and Signal Transduction

: The rational in silico design of interface mutations within protein complexes is a synthetic biology tool that enables-when introduced into biological systems-the artificial rewiring of biological pathways. Here we describe the three-dimensional structure-based design of "rewiring" mutations using the FoldX force field. Specifically, we provide the protocol for the design and selection of interface mutations in three Ras-effector complex structures (PDB entries 3KUD, 4K81, and 6AMB). Ras mutations that impair binding to some but not all interacting partners are selected

Podcast #1: Die Wahl in den USA

Heute vor einem Jahr ist dieses Blog gestartet. Und heute Nacht fand die Präsidentschaftswahl in den USA statt. Grund genug, unseren ersten Podcast diesem Thema zu widmen. Christopher Daase und Julian Junk vom sicherheitspolitik-blog.de diskutieren über die sicherheitspolitischen Implikationen der Wiederwahl Barack Obamas: Wird die Administration weiterhin außenpolitisch ähnlich zurückhaltend agieren? Ist dies nicht ein Widerspruch zu den großen Visionen wie Global Zero? Und wird der Drohnenkrieg unvermindert fortgesetzt? Die Moderation übernahm Philipp Offermann