Auditory startle response predicts introversion: an individual analysis

We assessed a possible link between the Introversion/Extraversion spectrum and sensori-motor gating and predicted self-reported introverts would have more sensitive sensori-motor gating pathways than extraverts at the individual subject level. 28 subjects self-identified as introverts or extraverts; individuals that self-identified as both introverted and extraverted were classified as ambiverts . Participants\u27orbicularis oculus muscles were electromyographically measured while abrupt auditory stimuli ranging from 50 to 100 decibels were played over headphones. As predicted, introverts exhibited greater electromyographical frequencies and magnitudes of response to stimuli at almost all levels of stimulus intensity. These results indicate introverts tend to be more sensitive, on a physiological level, to incoming stimuli compared to extraverts; this finding counters explanations of introversion as a purely social construct. Interestingly, a further and unpredicted pattern of three distinct groups was also observed. These groups are not organized along the lines of introversion/extraversion and may be linked to the concept of neuroticism

Copper ion removal from dilute solutions using ultrasonically synthesised BSA- and EWP-coated air bubbles

The aim of this study was to remove copper ions from dilute copper solution using an innovative material known as air-filled emulsion (AFE). AFE is composed of microscopic bubbles enclosed by a thin film of cysteine-rich protein distributed through the aqueous solution. The method using AFE as an extractant is combination of air-assisted solvent extraction (AASX) and biosorption techniques. The data obtained from X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) clearly showed the thiol, amino and carboxylic groups of bovine serum albumin (BSA) and egg white protein (EWP)-coated bubbles being responsible for copper adsorption. Moreover, it was also observed that manipulation of experimental conditions such as solution pH, temperature, biosorbent and copper concentration had a significant impact on copper ion uptake. Higher solution pH led to a greater metal uptake for both egg white protein emulsion (EWPEM) and bovine serum albumin emulsion (BSAEM). At lower pH, copper removal diminished and no copper removal was obtained at pH 2 due to the high concentration of hydrogen ions. The increase of copper uptake with temperature rise was due to both the exposure of more functional groups that were initially buried in the interior of the protein structure and an increase in reaction kinetics

Diffusive hidden Markov model characterization of DNA looping dynamics in tethered particle experiments

In many biochemical processes, proteins bound to DNA at distant sites are brought into close proximity by loops in the underlying DNA. For example, the function of some gene-regulatory proteins depends on such DNA looping interactions. We present a new technique for characterizing the kinetics of loop formation in vitro, as observed using the tethered particle method, and apply it to experimental data on looping induced by lambda repressor. Our method uses a modified (diffusive) hidden Markov analysis that directly incorporates the Brownian motion of the observed tethered bead. We compare looping lifetimes found with our method (which we find are consistent over a range of sampling frequencies) to those obtained via the traditional threshold-crossing analysis (which can vary depending on how the raw data are filtered in the time domain). Our method does not involve any time filtering and can detect sudden changes in looping behavior. For example, we show how our method can identify transitions between long-lived, kinetically distinct states that would otherwise be difficult to discern

Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction

Epidemiological and clinical studies provide compelling support for a causal relationship between Helicobacter pylori infection and endothelial dysfunction, leading to vascular diseases. However, clear biochemical evidence for this association is limited. In the present study, we have conducted a comprehensive investigation of endothelial injury in bovine aortic endothelial cells (BAECs) induced by H. pylori-conditioned medium (HPCM) prepared from H. pylori 60190 [vacuolating cytotoxin A (Vac(+))]. BAECs were treated with either unconditioned media, HPCM (0-25% vol/vol), or Escherichia coli-conditioned media for 24 h, and cell functions were monitored. Vac(+) HPCM significantly decreased BAEC proliferation, tube formation, and migration (by up to 44%, 65%, and 28%, respectively). Posttreatment, we also observed sporadic zonnula occludens-1 immunolocalization along the cell-cell border, and increased BAEC permeability to FD40 Dextran, indicating barrier reduction. These effects were blocked by 5-nitro-2-(3-phenylpropylamino)benzoic acid (VacA inhibitor) and were not observed with conditioned media prepared from either VacA-deleted H. pylori or E. coli. The cellular mechanism mediating these events was also considered. Vac(+) HPCM (but not Vac(-)) reduced nitric oxide (NO) by \u3e50%, whereas S-nitroso-N-acetylpenicillamine, an NO donor, recovered all Vac(+) HPCM-dependent effects on cell functions. We further demonstrated that laminar shear stress, an endothelial NO synthase/NO stimulus in vivo, could also recover the Vac(+) HPCM-induced decreases in BAEC functions. This study shows, for the first time, a significant proatherogenic effect of H. pylori-secreted factors on a range of vascular endothelial dysfunction markers. Specifically, the VacA-dependent reduction in endothelial NO is indicated in these events. The atheroprotective impact of laminar shear stress in this context is also evident

A Cosmological Framework for the Co-Evolution of Quasars, Supermassive Black Holes, and Elliptical Galaxies: I. Galaxy Mergers & Quasar Activity

(Abridged) We develop a model for the cosmological role of mergers in the evolution of starbursts, quasars, and spheroidal galaxies. Combining halo mass functions (MFs) with empirical halo occupation models, we calculate where major galaxy-galaxy mergers occur and what kinds of galaxies merge, at all redshifts. We compare with observed merger MFs, clustering, fractions, and small-scale environments, and show that this yields robust estimates in good agreement with observations. Making the simple ansatz that major, gas-rich mergers cause quasar activity, we demonstrate that this naturally reproduces the observed rise and fall of the quasar luminosity density from z=0-6, as well as quasar LFs, fractions, host galaxy colors, and clustering as a function of redshift and luminosity. The observed excess of quasar clustering on small scales is a natural prediction of the model, as mergers preferentially occur in regions with excess small-scale galaxy overdensities. We show that quasar environments at all observed redshifts correspond closely to the empirically determined small group scale, where mergers of gas-rich galaxies are most efficient. We contrast with a secular model in which quasar activity is driven by bars/disk instabilities, and show that while these modes probably dominate at Seyfert luminosities, the constraints from clustering (large and small-scale), pseudobulge populations, disk MFs, luminosity density evolution, and host galaxy colors argue that they must be a small contributor to the z>1 quasar luminosity density.Comment: 34 pages, 27 figures, submitted to ApJ. Fixed appearance of Figure

The most creative organization in the world? The BBC, 'creativity' and managerial style

The managerial styles of two BBC directors-general, John Birt and Greg Dyke, have often been contrasted but not so far analysed from the perspective of their different views of 'creative management'. This article first addresses the orthodox reading of 'Birtism'; second, it locates Dyke's 'creative' turn in the wider context of fashionable neo-management theory and UK government creative industries policy; third, it details Dyke's drive to change the BBC's culture; and finally, it concludes with some reflections on the uncertainties inherent in managing a creative organisation

Improving the lake scheme within a coupled WRF‐lake model in the Laurentian Great Lakes

In this study, a one‐dimensional (1‐D) thermal diffusion lake model within the Weather Research and Forecasting (WRF) model was investigated for the Laurentian Great Lakes. In the default 10‐layer lake model, the albedos of water and ice are specified with constant values, 0.08 and 0.6, respectively, ignoring shortwave partitioning and zenith angle, ice melting, and snow effect. Some modifications, including a dynamic lake surface albedo, tuned vertical diffusivities, and a sophisticated treatment of snow cover over lake ice, have been added to the lake model. A set of comparison experiments have been carried out to evaluate the performances of different lake schemes in the coupled WRF‐lake modeling system. Results show that the 1‐D lake model is able to capture the seasonal variability of lake surface temperature (LST) and lake ice coverage (LIC). However, it produces an early warming and quick cooling of LST in deep lakes, and excessive and early persistent LIC in all lakes. Increasing vertical diffusivity can reduce the bias in the 1‐D lake but only in a limited way. After incorporating a sophisticated treatment of lake surface albedo, the new lake model produces a more reasonable LST and LIC than the default lake model, indicating that the processes of ice melting and snow accumulation are important to simulate lake ice in the Great Lakes. Even though substantial efforts have been devoted to improving the 1‐D lake model, it still remains considerably challenging to adequately capture the full dynamics and thermodynamics in deep lakes.Key PointsA dynamic lake surface albedo scheme is added to the lake modelThe new lake model produces a more reasonable LST and LIC than the default lake modelIce melting and snow accumulation are important to simulating lake ice in the Great LakesPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135995/1/jame20346_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135995/2/jame20346.pd

Modeling the Dust Properties of z ~ 6 Quasars with ART^2 -- All-wavelength Radiative Transfer with Adaptive Refinement Tree

The detection of large quantities of dust in z ~ 6 quasars by infrared and radio surveys presents puzzles for the formation and evolution of dust in these early systems. Previously (Li et al. 2007), we showed that luminous quasars at z > 6 can form through hierarchical mergers of gas-rich galaxies. Here, we calculate the dust properties of simulated quasars and their progenitors using a three-dimensional Monte Carlo radiative transfer code, ART^2 -- All-wavelength Radiative Transfer with Adaptive Refinement Tree. ART^2 incorporates a radiative equilibrium algorithm for dust emission, an adaptive grid for inhomogeneous density, a multiphase model for the ISM, and a supernova-origin dust model. We reproduce the SED and dust properties of SDSS J1148+5251, and find that the infrared emission are closely associated with the formation and evolution of the quasar host. The system evolves from a cold to a warm ULIRG owing to heating and feedback from stars and AGN. Furthermore, the AGN has significant implications for the interpretation of observation of the hosts. Our results suggest that vigorous star formation in merging progenitors is necessary to reproduce the observed dust properties of z~6 quasars, supporting a merger-driven origin for luminous quasars at high redshifts and the starburst-to-quasar evolutionary hypothesis. (Abridged)Comment: 26 pages, 22 figures, accepted by ApJ. Version with full resolution images is available at http://www.cfa.harvard.edu/~yxli/ARTDUST/astroph0706.3706.pd

The Impact of Hotspot-Targeted Interventions on Malaria Transmission in Rachuonyo South District in the Western Kenyan Highlands: A Cluster-Randomized Controlled Trial.

BACKGROUND: Malaria transmission is highly heterogeneous, generating malaria hotspots that can fuel malaria transmission across a wider area. Targeting hotspots may represent an efficacious strategy for reducing malaria transmission. We determined the impact of interventions targeted to serologically defined malaria hotspots on malaria transmission both inside hotspots and in surrounding communities. METHODS AND FINDINGS: Twenty-seven serologically defined malaria hotspots were detected in a survey conducted from 24 June to 31 July 2011 that included 17,503 individuals from 3,213 compounds in a 100-km2 area in Rachuonyo South District, Kenya. In a cluster-randomized trial from 22 March to 15 April 2012, we randomly allocated five clusters to hotspot-targeted interventions with larviciding, distribution of long-lasting insecticide-treated nets, indoor residual spraying, and focal mass drug administration (2,082 individuals in 432 compounds); five control clusters received malaria control following Kenyan national policy (2,468 individuals in 512 compounds). Our primary outcome measure was parasite prevalence in evaluation zones up to 500 m outside hotspots, determined by nested PCR (nPCR) at baseline and 8 wk (16 June-6 July 2012) and 16 wk (21 August-10 September 2012) post-intervention by technicians blinded to the intervention arm. Secondary outcome measures were parasite prevalence inside hotpots, parasite prevalence in the evaluation zone as a function of distance from the hotspot boundary, Anopheles mosquito density, mosquito breeding site productivity, malaria incidence by passive case detection, and the safety and acceptability of the interventions. Intervention coverage exceeded 87% for all interventions. Hotspot-targeted interventions did not result in a change in nPCR parasite prevalence outside hotspot boundaries (p ≥ 0.187). We observed an average reduction in nPCR parasite prevalence of 10.2% (95% CI -1.3 to 21.7%) inside hotspots 8 wk post-intervention that was statistically significant after adjustment for covariates (p = 0.024), but not 16 wk post-intervention (p = 0.265). We observed no statistically significant trend in the effect of the intervention on nPCR parasite prevalence in the evaluation zone in relation to distance from the hotspot boundary 8 wk (p = 0.27) or 16 wk post-intervention (p = 0.75). Thirty-six patients with clinical malaria confirmed by rapid diagnostic test could be located to intervention or control clusters, with no apparent difference between the study arms. In intervention clusters we caught an average of 1.14 female anophelines inside hotspots and 0.47 in evaluation zones; in control clusters we caught an average of 0.90 female anophelines inside hotspots and 0.50 in evaluation zones, with no apparent difference between study arms. Our trial was not powered to detect subtle effects of hotspot-targeted interventions nor designed to detect effects of interventions over multiple transmission seasons. CONCLUSIONS: Despite high coverage, the impact of interventions targeting malaria vectors and human infections on nPCR parasite prevalence was modest, transient, and restricted to the targeted hotspot areas. Our findings suggest that transmission may not primarily occur from hotspots to the surrounding areas and that areas with highly heterogeneous but widespread malaria transmission may currently benefit most from an untargeted community-wide approach. Hotspot-targeted approaches may have more validity in settings where human settlement is more nuclear. TRIAL REGISTRATION: ClinicalTrials.gov NCT01575613

The Twisted Magnetic Field of the Protobinary L483

We present H-band (1.65 μm) and SOFIA HAWC+ 154 μm polarization observations of the low-mass core L483. Our H-band observations reveal a magnetic field that is overwhelmingly in the E–W direction, which is approximately parallel to the bipolar outflow that is observed in scattered IR light and in single-dish 12CO observations. From our 154 μm data, we infer a ∼45° twist in the magnetic field within the inner 5″ (1000 au) of L483. We compare these new observations with published single-dish 350 μm polarimetry and find that the 10,000 au scale H-band data match the smaller-scale 350 μm data, indicating that the collapse of L483 is magnetically regulated on these larger scales. We also present high-resolution 1.3 mm Atacama Large Millimeter/submillimeter Array data of L483 that reveals it is a close binary star with a separation of 34 au. The plane of the binary of L483 is observed to be approximately parallel to the twisted field in the inner 1000 au. Comparing this result to the ∼1000 au protostellar envelope, we find that the envelope is roughly perpendicular to the 1000 au HAWC+ field. Using the data presented, we speculate that L483 initially formed as a wide binary and the companion star migrated to its current position, causing an extreme shift in angular momentum thereby producing the twisted magnetic field morphology observed. More observations are needed to further test this scenario