Facework in English and German sociable episodes

This research focuses on cross-cultural differences in facework between English and German conversation. Specifically, the research addresses facework occurring as part and parcel of sociable conversation, as it is played out within moments of focused topic development - what I term 'sociable episodes'. Drawing on extant literature, the study identifies a range of communicative parameters along which English and German communicative style has been shown to differ, non more so than those suggesting different facework norms, and orientation to face needs as opposed to such things as ideational aspects of talk. In an attempt to address these differences, the study develops a model of facework - facework as alignment -which is posited as being appropriate to the study of essentially apolite conversational interaction. Further, although utilising the notions of ritual equilibrium (Goffman 1967) and positive - negative aspects of face (Brown and Levinson), the posited model of facework focuses specifically on aspects of sociable selfhood informing sociable conversation. It is argued that facework in sociable episodes is a matter of positive and negative alignment of sociable selves in and through the claiming of solidarity with and autonomy from other co-participants in terms of expressions of definitions, evaluations, experiences. In terms of English - German differences, these are demonstrated to be a matter of alignment of different sociable selves, ones normatively and routinely positively and negatively aligned in the achievement of sociable conversation, and ones indexing prevailing but culturally differing positive social values (Goffman 1967). The study concludes by identifying areas for future research based on the facework as alignment model developed and applied throughout the thesis.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Spelling out stigma Low-literate adults' verbal accounts of everyday life

SIGLEAvailable from British Library Document Supply Centre-DSC:8070.780(26) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis

Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been identified in these regions, no causative correlations have been drawn between deletion or mutation of these and lung carcinogenesis. We identify XPC and Gadd45a as genes within each of these regions involved in lung tumor initiation and progression, respectively. One hundred percent of XPC-/- mice develop multiple spontaneous lung tumors with a minority progressing to non-small cell lung adenocarcinoma, occasionally with metastasis to adjacent lymph nodes. Deletion of Gadd45a alone does not lead to increased lung tumors in mice, but coupled with an XPC deletion, it results in lung tumor progression. Analysis of published data indicated allelic loss of XPC in most human lung tumors and allelic loss of Gadd45a in some human lung and other cancer types. Because DNA repair capacity is compromised in XPC+/- cells, it is possible that the loss of a single XPC allele in the human lung might confer a mutator phenotype. Coupled with cigarette carcinogens, decreased DNA repair would lead to additional mutations in genes such as p53 that are frequent targets in lung cancer