Incubation period and duration of clinical period.

<p>Internal red bars indicate clinical disease. Day zero is the day the oral inoculations were initiated.</p

Survival curve of white-tailed deer orally challenged with CWD agents.

<p>Animals with only wild type alleles (blue) succumb to disease faster than individuals carrying at least one of the polymorphisms in positions 95 and 96 (Red). Wt/Q95H and Q95H/G96S animals present longer incubation periods and succumb to disease at similar times.</p

PrP^CWD electrophoretic patterns in different <i>PRNP</i> backgrounds.

<p>Brain homogenates with (+) or without (−) PK digestion were resolved by western blot using monoclonal antibody 8G8.</p

Immunohistochemical detection of PrP^CWD in the obex region of white tailed deer infected with CWD: A) wt/wt, B) wt/G96S, C) wt/Q95H and D) Q95H/G96S.

<p>Regions are indicated as: V = dorsal nucleus of the vagal nerve; S = nucleus of the solitary tract; T = spinal trigeminal nucleus and H = hypoglossal nucleus.</p

<i>PRNP</i> locus traits of orally challenged white-tailed deer.

<p>Silent polymorphisms, the presence or absence of the pseudo-gene and amino acid substitutions linked to disease progression (highlighted) are listed for each animal. Only one animal presented both amino acid substitutions in different alleles at the same time (Bold font).</p