14 research outputs found
Parental characteristic patterns associated with maintaining healthy physical activity behavior during childhood and adolescence
Treprostinil for the Treatment of Pulmonary Arterial Hypertension in Patients with New York Heart Association Class II–IV Symptoms
Papa was a rollin’ stone: how father’s psychological distress impacts child’s internalizing and externalizing symptoms
Treprostinil for pulmonary hypertension
Treprostinil (Remodulin, United Therapeutics) is a stable, long-acting prostacyclin analog, which has been shown to improve clinical state, functional class, exercise capacity and quality of life in patients with pulmonary arterial hypertension, an uncommon disease with poor prognosis. The drug is administered as a continuous subcutaneous infusion using a portable miniature delivery system. Side effects include facial flush, headache, jaw pain, abdominal cramping and diarrhea. These are all typical of prostacyclin impregnation and manageable by symptom-directed dose adjustments. Infusion site pain, a more serious side effect, may limit the treatment in 10% of patients. Otherwise, treprostinil has an excellent safety profile and compares favorably with reference continuous intravenous epoprostenol (Flolan, GlaxoSmithKline) therapy. Treprostinil has a place in currently proposed treatment algorithms of pulmonary arterial hypertension.SCOPUS: ar.jinfo:eu-repo/semantics/publishe