111 research outputs found
Global IT Multisourcing: Objectives, Challenges And Requirements In Multinational Insurance Companies
In recent times, information technology (IT) multisourcing has emerged as a key strategy in the field of IT outsourcing. Most of the current scholarlyand practitioner-related literature acknowledges the importance of multisourcing, but linear extensions of the dyadic client-vendor relationship are insufficient to capture its nuances. Multinational financial services providers (such as banks and insurance companies) have been pioneers in the fieldof IT outsourcing. However, there is a lack of experience-based research about the implementation of global IT multisourcing. In this article we present findings from a cross-case study investigating the implementation of global IT multisourcing in four leading insurance companies. First, the article presents the objectives of the insurers in pursuing global IT multisourcing. Second, the researchreveals challenges the companies are facing in implementing global IT multisourcing. Finally, requirements for implementing IT multisourcing are derived. The insights of these real-life examples extend existing literature on IT outsourcing and provide helpful orientation for organizations that are implementing global IT multisourcing
Deriving a Research Agenda for the Management of Multisourcing Relationships Based on a Literature Review
There has been considerable development in Information Technology (IT) outsourcing during the last two decades. Nowadays, practitioner-related as well as scholarly literature have identified multisourcing as an emerging key strategy. Multisourcing is described as the blending of services from multiple internal and external vendors. Especially in the case of multisourcing the management of relationships is complex. For a certain field of research it is important to have an overview of the existing literature and a common understanding of basic terms. In this article we identify and analyze the body of knowledge in the area of managing multisourcing relationships. We hence conduct a structured literature review based upon an established literature review framework. It can be observed that the current literature lacks depth in terms of management of multisourcing relationships and that only a few articles cover the aspects of multisourcing in detail. Particularly regarding performance management, governance and knowledge management of multisourcing relationships we propose further research. We subsequently deduce a detailed research agenda for future research options
Towards a Better Understanding of IT Cost Drivers of Asset Management Companies
Effectiveness and even more efficiency are substantial indicators of information technology (IT) performance management. Evaluation of an organisation’s IT performance relies heavily on benchmarking with other organisations. The comparability of IT key performance indicators (KPIs) is critical for resilient benchmarking results. KPI suggestions of established frameworks remain very generic. They are incapable of taking individual characteristics of different business models into account and impede, therefore, a sophisticated benchmarking. Such an occurrence can be observed frequently, especially in the environment of business groups. In the case of one leading international financial service business group, we analysed this problem and applied action research to identify IT cost drivers and develop specific KPIs for the group IT performance management. This article provides insights into a real-life example of evaluating IT performance and suggests a set of KPIs for IT cost efficiency benchmarking among asset management firms within a business group considering the firm’s different business models
IT Shared Service Center and External Market Activities
In the last few years many corporate groups reorganized their IT-Services and established IT Shared Service Centers (IT SSC). These IT SSCs primarily delivered IT services internally; nevertheless some IT SSC provided IT services to external customers as well. These external market activities failed in most cases. In spite of the relevance to organizations, little research has been done investigating the reasons for such failures. In order to address this issue, we have conducted a qualitative study with eight IT SSC cases and five experts interviews. We have triangulated the results between the case studies and the expert interviews and we have identified two set of factors, one explaining IT SCC successes in internal markets and the other explaining IT SSC failures in external markets. The enabling factors for the successes of IT SSCs in internal markets include having the same corporate culture, knowledge of the parent organization and its processes, lower transactions cost, lower average cost, no dependence on external IT service providers, better data protection, improved IT opportunities and obligation to provide services. The factors explaining external market failures include the lack of experience with acquisition, no professional sales and marketing, lack of investment funds, weak unique features of IT services, reassessment of strategic group portfolio by the parent company, higher IT service costs, and inconsistent business models. These findings are relevant to managers of IT SSCs to make decisions on their corporate strategy, as well as to researchers to utilize these findings as a starting point for future research on IT SSCs
Fostering Efficiency in Information Systems Support for Product-Service Systems in the Manufacturing Industry
The ongoing shift towards stronger service orientation is leading to a rising number of industrial services offered in the manufacturing industry. In the attempt to fulfill ever-increasing service demands while at the same time reducing operating costs, manufacturing firms search for appropriate information technology (IT) solution for planning and execution. The industry has not yet reached a common understanding of product-service systems and the corresponding processes and IT systems. In order to holistically support such broad design and transformation tasks, we develop a maturity model capturing the key requirements for the information systems (IS) support of product-service systems based on a multiple case study. For a critical reflection on the extant literature, we compared those requirements with scientifically recognized maturity models and standard specifications. Being an integral part of the design science research approach, the model evaluation is organized in accordance with approved evaluation perspectives
Hypermatrix factors for string and membrane junctions
The adjoint representations of the Lie algebras of the classical groups
SU(n), SO(n), and Sp(n) are, respectively, tensor, antisymmetric, and symmetric
products of two vector spaces, and hence are matrix representations. We
consider the analogous products of three vector spaces and study when they
appear as summands in Lie algebra decompositions. The Z3-grading of the
exceptional Lie algebras provide such summands and provides representations of
classical groups on hypermatrices. The main natural application is a formal
study of three-junctions of strings and membranes. Generalizations are also
considered.Comment: 25 pages, 4 figures, presentation improved, minor correction
Explicit solution of the quantum three-body Calogero-Sutherland model
Quantum integrable systems generalizing Calogero-Sutherland systems were
introduced by Olshanetsky and Perelomov (1977). Recently, it was proved that
for systems with trigonometric potential, the series in the product of two wave
functions is a deformation of the Clebsch-Gordan series. This yields recursion
relations for the wave functions of those systems. In this note, this approach
is used to compute the explicit expressions for the three-body
Calogero-Sutherland wave functions, which are the Jack polynomials. We
conjecture that similar results are also valid for the more general
two-parameters deformation introduced by Macdonald.Comment: 10 page
Managing urinary tract infections
Urinary tract infections (UTI) are common in childhood. Presence of pyuria and bacteriuria in an appropriately collected urine sample are diagnostic of UTI. The risk of UTI is increased with an underlying urological abnormality such as vesicoureteral reflux, constipation, and voiding dysfunction. Patients with acute pyelonephritis are at risk of renal scarring and subsequent complications such as hypertension, proteinuria with and without FSGS, pregnancy-related complications and even end-stage renal failure. The relevance and the sequence of the renal imaging following initial UTI, and the role of antimicrobial prophylaxis and surgical intervention are currently undergoing an intense debate. Prompt treatment of UTI and appropriate follow-up of those at increased risk of recurrence and/or renal scarring are important
Dysfunctional GABAergic inhibition in the prefrontal cortex leading to "psychotic" hyperactivation
<p>Abstract</p> <p>Background</p> <p>The GABAergic system in the brain seems to be dysfunctional in various psychiatric disorders. Many studies have suggested so far that, in schizophrenia patients, GABAergic inhibition is selectively but consistently reduced in the prefrontal cortex (PFC).</p> <p>Results</p> <p>This study used a computational model of the PFC to investigate the dynamics of the PFC circuit with and without chandelier cells and other GABAergic interneurons. The inhibition by GABAergic interneurons other than chandelier cells effectively regulated the PFC activity with rather low or modest levels of dopaminergic neurotransmission. This activity of the PFC is associated with normal cognitive functions and has an inverted-U shaped profile of dopaminergic modulation. In contrast, the chandelier cell-type inhibition affected only the PFC circuit dynamics in hyperdopaminergic conditions. Reduction of chandelier cell-type inhibition resulted in bistable dynamics of the PFC circuit, in which the upper stable state is associated with a hyperactive mode. When both types of inhibition were reduced, this hyperactive mode and the conventional inverted-U mode merged.</p> <p>Conclusion</p> <p>The results of our simulation suggest that, in schizophrenia, a reduction of GABAergic inhibition increases vulnerability to psychosis by (i) producing the hyperactive mode of the PFC with hyperdopaminergic neurotransmission by dysfunctional chandelier cells and (ii) increasing the probability of the transition to the hyperactive mode from the conventional inverted-U mode by dysfunctional GABAergic interneurons.</p
Clinical Use and Therapeutic Potential of IVIG/SCIG, Plasma-Derived IgA or IgM, and Other Alternative Immunoglobulin Preparations
Intravenous and subcutaneous immunoglobulin preparations, consisting of IgG class antibodies, are increasingly used to treat a broad range of pathological conditions, including humoral immune deficiencies, as well as acute and chronic inflammatory or autoimmune disorders. A plethora of Fab- or Fc-mediated immune regulatory mechanisms has been described that might act separately or in concert, depending on pathogenesis or stage of clinical condition. Attempts have been undertaken to improve the efficacy of polyclonal IgG preparations, including the identification of relevant subfractions, mild chemical modification of molecules, or modification of carbohydrate side chains. Furthermore, plasma-derived IgA or IgM preparations may exhibit characteristics that might be exploited therapeutically. The need for improved treatment strategies without increase in plasma demand is a goal and might be achieved by more optimal use of plasma-derived proteins, including the IgA and the IgM fractions. This article provides an overview on the current knowledge and future strategies to improve the efficacy of regular IgG preparations and discusses the potential of human plasma-derived IgA, IgM, and preparations composed of mixtures of IgG, IgA, and IgM
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