393 research outputs found
Our Town: A Heartland Lynching, A Haunted Town, and the Hidden History of White America
Review of: Our Town: A Heartland Lynching, a Haunted Town, and the Hidden History of White America, by Cynthia Carr
The Bellevue War: Mandate of Justice or Murder by Mob: A True â and Still Controversial â Story of Iowa as the Wild West
Review of: "The Bellevue War: Mandate of Justice or Murder by Mob? A True - and Still Controversial - Story of Iowa as the Wild West,"by Susan K. Lucke
The Catholic Church in Southwest Iowa
Review of: The Catholic Church in Southwest Iowa, by Steven M. Avella
Our Town: A Heartland Lynching, A Haunted Town, and the Hidden History of White America
Review of: "Our Town: A Heartland Lynching, a Haunted Town, and the Hidden History of White America," by Cynthia Carr
The Catholic Church in Southwest Iowa
Review of: "The Catholic Church in Southwest Iowa," by Steven M. Avella
Two novel proteins, TtpB2 and TtpD2, are essential for iron transport in the TonB2 system of Vibrio vulnificus
In gramânegative bacteria, energyâdependent active transport of ironâbound subâ strates across the outer membrane is achieved through the TonB systems of proteins. Three TonB systems have been identified in the human pathogen Vibrio vulnificus. The TonB1 system contains three proteins: TonB1, ExbB1, and ExbD1. Both the TonB2 and TonB3 systems have been shown to also contain a fourth protein, TtpC2 and TtpC3, respectively. Here, we report and begin to characterize two additional proteins in the TonB2 and TonB3 systems: TtpB and TtpD. Both TtpB2 and TtpD2 are absolutely required for the function of the TonB2 system in V. vulnificus. However, although both TtpB3 and TtpD3 in the TonB3 system are related to the proteins in the TonB2 system, neither are active in iron transport. All six protein components of the TonB2 systemâTonB2, ExbB2, ExbD2, TtpB2, TtpC2, and TtpD2âare essential for the uptake of both endogenously produced ironâbound siderophores and exogâ enous siderophores produced from other organisms. Through complementation, we have shown that V. vulnificus is capable of using different TtpD2 proteins from other Vibrio species to bring in multiple siderophores. In contrast, we also demonstrate that TtpB2 must come from V. vulnificus, and not other species within the genus, to complement mutations in the TonB2 system
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