Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of higher versus standard doses of caffeine on mortality and major neurodevelopmental disability in preterm infants with (or at risk of) apnea, and preterm infants peri-extubation. To determine the effects of early versus late discontinuation of caffeine administration on mortality and major neurodevelopmental disability in preterm infants with (or at risk of) apnea, and preterm infants peri-extubation