Prospectus, November 14, 1969

WOULD ERNIE BANKS HAVE HIT 497 HOME RUNS IF HE\u27D GONE TO PARKLAND?; Editorials; Letters To The Editors; McCartney says Bloody Stupid ; Plastic Ono; Peter Reich on Space; At Last--- A Dean of Students; open trips to moon in 12 years; A Man for all Seasons: Dear Abbey...; Staerkel Fields Hot Grounders; Golfers Finish 5-7; First Game Is Tuesday: Cagers Experienced, Practices Sharphttps://spark.parkland.edu/prospectus_1969/1000/thumbnail.jp

Prospectus, January 27, 1970

NCA VISIT IS FAVORABLE; Student Gov\u27t Demands Action; Larry Bell Wins Alcoa Award; Election Results, Pay Vote Favorable; Black Rap; These Three Kings; Letters To The Editor; Student Code Now Official; Ski Club Plans Weekend; Parkland College Faculty Appointment; DeVore Memorial Service Held; From Who\u27s Point of View; James Lauds Students; Black Week At Parkland College; Black Panther Goals; Panthers To Protect Black Community; Outbrust Spark Panel Discussion; Bull Page: Advisor System, Calendar, Nixon Football and Politics, Illinois Grant Program, Writing Clinic, WANTED Yearbook Title, The Spieler, The Killer Was Pollution, Student Loans, Circle K Sponsors Dance; Synapse: Gold, Jacks, Rock & Roll Is Alive or Dead, The Bag, Four Days & A Night; !!! A Rock Opera; Bucks Lead in I.M.; Cobras Drop 3 in Texas; Cobras Trim Joliet, 92-88; A man for all seasons: Scholarships at Parkland?; Illini Frosh Trim Cobras 80-68; Vets Say Need Is Great; New Campus Developmentshttps://spark.parkland.edu/prospectus_1970/1033/thumbnail.jp

Prospectus, February 10, 1970

THE PARKING PROBLEM WHAT DO WE DO; Is Your Advisor--?; Editorials; Letters To The Editor; Black Rap; In-Sight Out; James Lauds Students, Part 2; The Welch Syndrome; Miss February; Havenly Is John Pennel; Synapse: Blizzards, Live Peace, Feather Train; Bull Page: P.C. Student Awarded Champaign C of C Scholarship, Calendar, Schorships, Plan Spring Formal, Grant Program For College Year 1970-1971, Suggestion Box, Research Project, Ice Skating; Eastern Frosh Down Cobras, 98-89; Cobras Nip Spoon River, 103-102; Florrisant Whips Grapplers, 26-16; A man for all seasons: No Baseball in 1970https://spark.parkland.edu/prospectus_1970/1032/thumbnail.jp

Prospectus, January 29, 1971

FORMER ACTOR TO DIRECT PLAY; Valley To Organize College Debate Team; Parkland Diagnosed By NCA Team; Problems Of Our Times: For the Welfare of Whom?; Students As Zombies; Letters to Editor; Environmental Teach-In Feb. 9, 10, 11: Oakley Project Has Long History; Nursing Program Gets Highest Accredidation Possible; Thoughts On Singing; Bull Page: 1971-1972 Grants, Hotline, Library Permits, Wit N\u27 Wisdom, Vets Meeting, SWAMP, Jr. College Day, Upcoming Events, Road Rally Results, Family Night, Yearbook Pictures, Gemini House, Activities Mailboxes; Parkland Bows to Meramec; Sports Briefs; Wrestlers Maul Meramec; Parkland Squeaks by Florissant Valley; Florissant Knocks Off Cobras; Intramural Standings; Penthouse Gang, Lucy\u27s Men Grab Division Lead; Wolfe Rates Parkland Sports; Cobras Fall at Wabashhttps://spark.parkland.edu/prospectus_1971/1014/thumbnail.jp

A revised host galaxy association for GRB 020819B: a high-redshift dusty starburst, not a low-redshift gas-poor spiral

The purported spiral host galaxy of GRB 020819B at z = 0.41 has been seminal in establishing our view of the diversity of long-duration gamma-ray burst environments: Optical spectroscopy of this host provided evidence that gamma-ray bursts (GRBs) can form even at high metallicities, whereas millimetric observations suggested that GRBs may preferentially form in regions with minimal molecular gas. We report new observations from the Very Large Telescope (Multi Unit Spectroscopic Explorer and X-shooter), which demonstrate that the purported host is an unrelated foreground galaxy. The probable radio afterglow is coincident with a compact, highly star forming, dusty galaxy at z = 1.9621. The revised redshift naturally explains the apparent non-detection of CO (3–2) line emission at the afterglow site from the Atacama Large Millimetre Observatory. There is no evidence that molecular gas properties in GRB host galaxies are unusual, and limited evidence that GRBs can form readily at a super-Solar metallicity

Dual Lipolytic Control of Body Fat Storage and Mobilization in Drosophila

Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by dysfunctions resulting in obesity and lipodystrophy in humans. Packaging of storage fat in intracellular lipid droplets, and the various molecules and mechanisms guiding storage-fat mobilization, are conserved between mammals and insects. We generated a Drosophila mutant lacking the receptor (AKHR) of the adipokinetic hormone signaling pathway, an insect lipolytic pathway related to ß-adrenergic signaling in mammals. Combined genetic, physiological, and biochemical analyses provide in vivo evidence that AKHR is as important for chronic accumulation and acute mobilization of storage fat as is the Brummer lipase, the homolog of mammalian adipose triglyceride lipase (ATGL). Simultaneous loss of Brummer and AKHR causes extreme obesity and blocks acute storage-fat mobilization in flies. Our data demonstrate that storage-fat mobilization in the fly is coordinated by two lipocatabolic systems, which are essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo

Psychosocial Risk Factors in Disordered Gambling: A Descriptive Systematic Overview of Vulnerable Populations

Background: Gambling is a behaviour engaged in by millions of people worldwide; for some, gambling can become a severely maladaptive behaviour, and previous research has identified a wide range of psychosocial risk factors that can be considered important for the development and maintenance of disordered gambling. Although risk factors have been identified, the homogeneity of risk factors across specific groups thought to be vulnerable to disordered gambling is to date, unexplored. Methods: To address this, the current review sought to conduct a systematic overview of literature relating to seven vulnerable groups: young people and adolescents, older adults, women, veterans, indigenous peoples, prisoners, and low socio-economic/income groups. Results: Multiple risk factors associated with disordered gambling were identified; some appeared consistently across most groups, including being male, co-morbid mental and physical health conditions, substance use disorders, accessibility and availability of gambling, form and mode of gambling, and experience of trauma. Further risk factors were identified that were specific to each vulnerable group. Conclusion: Within the general population, certain groups are more vulnerable to disordered gambling. Although some risk factors are consistent across groups, some risk factors appear to be group specific. It is clear that there is no homogenous pathway in to disordered gambling, and that social, developmental, environmental and demographic characteristics can all interact to influence an individual’s relationship with gambling

Genetic predisposition to mosaic Y chromosome loss in blood.

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1-5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,114 men of European and Japanese ancestry. These loci highlight genes that are involved in cell-cycle regulation and cancer susceptibility, as well as somatic drivers of tumour growth and targets of cancer therapy. We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues. Single-cell RNA sequencing identifies dysregulated expression of autosomal genes in leukocytes with LOY and provides insights into why clonal expansion of these cells may occur. Collectively, these data highlight the value of studying clonal mosaicism to uncover fundamental mechanisms that underlie cancer and other ageing-related diseases.This research has been conducted using the UK Biobank Resource under application 9905 and 19808. This work was supported by the Medical Research Council [Unit Programme number MC_UU_12015/2]. Full study-specific and individual acknowledgements can be found in the supplementary information