Multi-national survey on the methods, efficacy, and safety on the post-approval clinical use of pulsed field ablation (MANIFEST-PF).

AIMS Pulsed field ablation (PFA) is a novel atrial fibrillation (AF) ablation modality that has demonstrated preferential tissue ablation, including no oesophageal damage, in first-in-human clinical trials. In the MANIFEST-PF survey, we investigated the 'real world' performance of the only approved PFA catheter, including acute effectiveness and safety-in particular, rare oesophageal effects and other unforeseen PFA-related complications. METHODS AND RESULTS This retrospective survey included all 24 clinical centres using the pentaspline PFA catheter after regulatory approval. Institution-level data were obtained on patient characteristics, procedure parameters, acute efficacy, and adverse events. With an average of 73 patients treated per centre (range 7-291), full cohort included 1758 patients: mean age 61.6 years (range 19-92), female 34%, first-time ablation 94%, paroxysmal/persistent AF 58/35%. Most procedures employed deep sedation without intubation (82.1%), and 15.1% were discharged same day. Pulmonary vein isolation (PVI) was successful in 99.9% (range 98.9-100%). Procedure time was 65 min (38-215). There were no oesophageal complications or phrenic nerve injuries persisting past hospital discharge. Major complications (1.6%) were pericardial tamponade (0.97%) and stroke (0.4%); one stroke resulted in death (0.06%). Minor complications (3.9%) were primarily vascular (3.3%), but also included transient phrenic nerve paresis (0.46%), and TIA (0.11%). Rare complications included coronary artery spasm, haemoptysis, and dry cough persistent for 6 weeks (0.06% each). CONCLUSION In a large cohort of unselected patients, PFA was efficacious for PVI, and expressed a safety profile consistent with preferential tissue ablation. However, the frequency of 'generic' catheter complications (tamponade, stroke) underscores the need for improvement

Relatório de estágio em farmácia comunitária

Relatório de estágio realizado no âmbito do Mestrado Integrado em Ciências Farmacêuticas, apresentado à Faculdade de Farmácia da Universidade de Coimbr

Rozhovor Britských listů 531. Za špatné volební výsledky mohou zastaralost myšlení a nekvalitní školy [Britské listy Interview 531. Outdated thinking and poor quality schools are to blame for poor election results in the Czech Republic]

Jan Čulík talks with Vojtěch Petrů, editor-in-chief of Studentské listy (The Students' Newspaper), about the strange results of the local elections which took place in the Czech Republic during the last weekend of September 2022. The interview was broadcast on the Czech cable TV station Regionalnitelevize.cz from 27th September 2022

Electronic Structure of Monolayer FeSe on Si(001) from First Principles

The huge increase in the superconducting transition temperature of FeSe induced by an interface to SrTiO3 remains unexplained to date. However, there are numerous indications of the critical importance of specific features of the FeSe band topology in the vicinity of the Fermi surface. Here, we explore how the electronic structure of FeSe changes when located on another lattice matched substrate, namely a Si(001) surface, by first-principles calculations based on the density functional theory. We study non-magnetic (NM) and checkerboard anti-ferromagnetic (AFM) magnetic orders in FeSe and determine which interface arrangement is preferred. Our calculations reveal interesting effects of Si proximity on the FeSe band structure. Bands corresponding to hole pockets at the Γ point in NM FeSe are generally pushed down below the Fermi level, except for one band responsible for a small remaining hole pocket. Bands forming electron pockets centered at the M point of the Brillouin zone become less dispersive, and one of them is strongly hybridized with Si. We explain these changes by a redistribution of electrons between different Fe 3d orbitals rather than charge transfer to/from Si, and we also notice an associated loss of degeneracy between dxz and dyz orbitals

File d'attente et généalogies d'un processus de branchement

On étudie une version d'une correspondance, mise en évidence par Kendall, entre processus de branchement et marches aléatoires. Le Gall et Le Jan l'ont généralisée pour étendre la construction du serpent brownien à des superprocessus à mécanisme de branchement plus général que celui quadratique. Sous des hypothèses encore plus générales, on exhibe une bijection qui transporte les arbres aléatoires marqués, associés à la généalogie d'un processus de branchement, sur les trajectoires d'une file d'attente et qui envoie la loi gouvernant l'histoire de la population sur la loi de la file. Les individus de la population étudiée portent deux marques: le type et la longueur de vie. Les fils de u, conditionné par rapport aux individus qui ne sont pas dans la descendance de u, naissent après des temps exponentiels et portent des marques indépendantes et identiquement distribuées, les lois conditionnelles ne dépendant que du type des ancêtres de u. La file d'attente est obtenue par une exploration déterministe d'abord en profondeur de la généalogie de la population. Cette file est un objet plus général que les processus de Lévy à sauts positifs. Ses propriétés peuvent être étudiées en s'appuyant entièrement sur les propriétés des arbres. Ainsi on montre comment la propriété de Markov de la file d'attente dérive de la propriété de branchement le long d'une branche de l'arbre aléatoire. Pour cela, on remplace le temps réel par un paramètre (branche) plus proche de la généalogie de l'arbre. On prouve la propriété de Markov forte pour la file d'attente dans les nouvelles coordonnées. La propriété de Markov forte en temps réel en découle, les temps optionnels étant des branches optionnelles. Cette technique exige une analyse très fine des rapports s'établissant entre le temps réel qui indexe la file d'attente et la structure généalogique de l'arbre aléatoire sous-jacent.We study a version of the correspondence between branching processes and random walks, that was discovered by Kendall. Le Gall and Le Jan generalized it in order to extend the brownian snake towards superprocesses with more general branching mechanism than the quadratic one. We establish, in more general hypothesis, a deterministic one-to-one map between the labelled random trees describing the genealogy of a branching process and the paths of a queue; this map transports the law which controls the history of the population in the law of the queue. The individuals in the population we study are labelled by their type and longevity. If one conditions with respect to the individuals not in the u's progeny, then u gives birth at exponential times to children bearing independent and identically distributed labels, the conditional laws depending only upon the type of u's ancestry. The queue is obtained via a deterministic depth first exploration of the genealogy of the population. This queue is a more general object than a Lévy process with no negative jumps. Its properties may be studied with the only aid of the corresponding properties of the trees. Thus, we show how the branching property of the tree along branches yields the Markov property of the queue. In this regard, we replace the time with a parameter (the branch) close to the genealogy of the tree and we prove the strong Markov property of the queue in these new coordinates. From this one gets the strong Markov property in real time, because optional times are optional branches. This technique requires a detailed analysis of the relations between the real time indexing the queue and the genealogical structure of the associated random tree.ORSAY-PARIS 11-BU Sciences (914712101) / SudocSudocFranceF

Use of Video Analysis of Conflict Situations for Monitoring the Traffic on Urban Road Influenced by Parallel Parking

The paper deals with problems of influence of parallel parking on urban roads for road traffic safety. It shortly refers to evaluation of normative principles related to parking of road vehicles in the Czech Republic.It presents the results of analysis of traffic participant behavior on the particular section of inhabited area by use of video analysis of conflict situations. Thus it is pointed out to a possibility of application of this methodology in execution of safety inspections on roads, for example