5 research outputs found
Identification of novel genetic risk factors of dilated cardiomyopathy: from canine to human
- Author
- Andersson G
- Asselbergs FW
- Donner J
- Dooijes D
- Drögemüller M
- Eberhard J
- Ernst RF
- Friederich J
- Harakalova M
- Hundi S
- Hytönen MK
- Häggström J
- Hörtenhuber M
- Kere J
- Leeb T
- Ljungvall I
- Lohi H
- Niskanen JE
- Ohlsson Å
- Petrič AD
- Postma AV
- Pyle WG
- Salonen M
- Snijders Blok CJB
- van Deutekom HWM
- van Setten J
- van Steenbeek FG
- van Tintelen JP
- van Vugt M
- Wess G
- Wiberg M
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
BACKGROUND: Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiology; however, as a complex disease, the exact genetic risk factors are largely unknown, and many patients remain without a molecular diagnosis. METHODS: We performed GWAS followed by whole-genome, transcriptome, and immunohistochemical analyses in a spontaneously occurring canine model of DCM. Canine gene discovery was followed up in three human DCM cohorts. RESULTS: Our results revealed two independent additive loci associated with the typical DCM phenotype comprising left ventricular systolic dysfunction and dilatation. We highlight two novel candidate genes, RNF207 and PRKAA2, known for their involvement in cardiac action potentials, energy homeostasis, and morphology. We further illustrate the distinct genetic etiologies underlying the typical DCM phenotype and ventricular premature contractions. Finally, we followed up on the canine discoveries in human DCM patients and discovered candidate variants in our two novel genes. CONCLUSIONS: Collectively, our study yields insight into the molecular pathophysiology of DCM and provides a large animal model for preclinical studies
Study of the structural properties and degradation of coated wood with polydopamine/hydroxyapatite/chitosan hybrid nanocomposite in seawater
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Social informatics as a concept: Widening the discourse
- Author
- Afanasiev VG
- Beneš J
- Berce J
- Bishop A
- Bolognani M
- Bradley G
- Brookes BC
- Brugger N
- Bråten SL
- Cejpek J
- Chernyj AI
- Chugunov AV
- Dahlbom B
- De Chardin PT
- Denison T
- Endo K
- Ershov AP
- Fichman P
- Fourman M
- Gammack J
- Gorn S
- Gurstein M
- Halfar B
- Hofkirchner W
- Horton K
- Huth EJ
- Janatzek U
- Jurgovsky M
- Kamirov MF
- Karvalics LZ
- Kling R
- Kling R
- Kling R
- Kling R
- Kolin KK
- Kolin KK
- Kolin KK
- Kolin KK
- Kolin KK
- Kolin KK
- Kovář P
- Lapin NI
- Lappas G
- Lenin VI
- Ludviková M
- Maliţa L
- Masamura T
- Merta A
- Mikhailov AI
- Mikhailov AI
- Mikhailov AI
- Mikhailov AI
- Mochalov II
- Mumford E
- Nishigaki T
- Nishigaki T
- Petrič G
- Ponomareva YS
- Prokešová O
- Rosenbaum H
- Santos LR
- Santos LR
- Sawyer S
- Serenko A
- Sokolov AV
- Sokolov AV
- Sokolov AV
- Sokolov IA
- Sokolova IV
- Starikov S
- Steinbuch KW
- Straka J
- Strong DM
- Sultanov ES
- Svilicic N
- Tapia A
- Trubina MA
- Turner W
- Ursul AD
- Ursul AD
- Ursul AD
- Ursul AD
- Ursul AD
- Ursul AD
- Ursul AD
- Ursul AD
- Ursul AD
- Ursul AD
- Ursul AD
- Vehovar V
- Walker S
- Wood-Harper T
- Yoshida T
- Zdenek Smutny
- Zeman J
- Zinoviev D
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Blood pressure measurement in cats and dogs: considerations for the clinician
- Author
- Publication venue
- 'Mark Allen Group'
- Publication date
- Field of study
Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries
- Author
- ?tinas A
- Aalem HAA
- Ababneh H
- Abbas A
- Abbas A
- Abbas H
- Abbasi A
- Abbassi F
- Abbasy J
- Abbood AH
- Abboud K
- Abdallah A
- Abdalsalam SJA
- Abdelaal A
- Abdelalemm M
- Abdelhafez MHZ
- Abdelhalim K
- Abdeljalil M
- Abdelkarem M
- Abdelmageed A
- Abdelmageed A
- Abdelmaksoud M
- Abdelmawgoud S
- Abdelmawla M
- Abdelmawla MOMK
- Abdelmoneim N
- Abdelnoor A
- Abdelrahman F
- Abdelrazek HA
- Abdelrhman R
- Abdelzaher A
- Abdelzaher AT
- Abdou K
- Abdoun M
- Abdualqader M
- Abdualqader MYM
- Abdulhaq A
- Abduljawad H
- Abdullaev A
- Abdullah NAN
- Abdulmonem A
- Abdulwahed E
- Abebrese J
- Abiyere H
- Abobakr AM
- Aboelfath S
- Abosamak NE
- Abu Harb Z
- Abu Hilal M
- Abu Hilal M
- Abu Jayyab M
- Abu-Elfatth AM
- Abu-Ghazal S
- Abu-Ghazal SY
- Abuali ASAME
- Abuelazm M
- Abuelnaga Y
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- Abughazal SY
- Abuleil A
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- Adam I
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- Al-Dowsh NA
- Al-Eryani F
- Al-Faiq S
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- Al-juaifari MA
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- Windsor J
- Winslow E
- Wlazlak M
- Wolfgang C
- Wu CH
- Wu CH
- Wyroślak-Najs J
- Wüllenweber H-P
- Yadav K
- Yadev I
- Yadev I
- Yaghan R
- Yamamoto T
- Yang P-C
- Yassin LMA
- Yassin R
- Yegen C
- Yeo C
- Yesilyurt D
- Yip V
- Yoong B
- Yoong BK
- Younes E
- Younes E
- Young A
- Yousef A
- Youssef A
- Yu M-C
- Zacharakis E
- Zacharoulis D
- Zachiotis M
- Zagainov V
- Zaharie F
- Zahed M
- Zahed MSM
- Zakaria AD
- Zamri FMB
- Zanatta M
- Zanello M
- Zanini N
- Zanus G
- Zanus G
- Zaruba P
- Zawia A
- Zayed A
- Zdujic P
- Zedelj J
- Zeh HJ
- Zentar A
- Zerbi A
- Zidan T
- Zidan T
- Zironda A
- Zitawi A
- Zivanovic M
- Zogopoulos G
- Zonta S
- Zonta S
- Zorrilla CF
- Zozaya G
- Zreqat Q
- Zuhdi Z
- Zuhdy M
- Zygomalas A
- álvarez PM
- çelik M
- çetiindağ Ö
- Çiftci AB
- çoker A
- öfkeli Ö
- özet A
- Šileikis A
- Šlepavičius A
- Štironja I
- Publication venue
- Publication date
- 18/01/2024
- Field of study