Nastajanje i karakterizacija bistiourea cinkovoga formata

Formation of a new complex in the Zn(HCOO)2-CS(NH2)2-H2O system at 25 °C was established by the solubility method. Its composition was determined to be Zn(HCOO)2 * 2CS(NH2)2. The bisthiourea zinc formate (BTZF) is an incongruently soluble salt at 25 °C. It has been characterized by X-ray powder diffraction, IR spectroscopy and thermal analysis. The infrared spectra reveal that thiourea forms a zinc-sulfur bond. Thermal decomposition at a temperature of 400 °C yields ZnS.Ustanovljeno je da metodom topljivosti u sustavu Zn(HCOO)2-CS(NH2)2-H2O pri 25 °C nastaje novi kompleksnispoj. Određivanje sastava pokazalo je da se radi o Zn(HCOO)2 * 2CS(NH2)2. Pri 25 °C bistiourea cinkov format (BTZF) neprimjereno je topljiva sol. Spoj je opisan rentgenskom difrakcijom na prahu, IR spektroskopijom i termičkom analizom. U infracrvenom spektru otkrivena je vrpca koja odgovara vezi cink-sumpor. Termički raspad spoja završava kod temperature 400 °C pri čemu zaostaje cinkov sulfid

Structure-Activity Relationships of N-Cinnamoyl and Hydroxycinnamoyl Amides on α-Glucosidase Inhibition

Currently, there is an increasing interest towards α-glucosidase inhibition of various diseases including diabetes mellitus type 2, cancer, HIV, and B- and C-type viral hepatitis. Cinnamic acid derivatives have been shown to be potentially valuable as a new group of α-glucosidase inhibitors. Therefore, herein, the α-glucosidase inhibitory activity of trans-N-cinnamoyl and hydroxycinnamoyl amides was studied in vitro. Results revealed that the tested hydroxycinnamoyl amides (1–16) inhibited a-glucosidase with IC50s ranging between 0.76 and 355.1 μg/ml. Compounds 1, 2, 5, 6, 9, 14, and 15 showed significant inhibition of yeast α-glucosidase, being even more potent ones than the used positive inhibitor acarbose (IC50=2.50±0.21 μg/ml)