SAPHO syndrome the therapeutical challenge

Introduction: Sapho syndrome is a syndrome characterizing with osteoarticular end dermatologic symptoms. Acronym 'SAPHO' means: S-Sinovitis, A-Acne, H-Hyperostosis, O-Osteytis. SAPHO syndrome has a 50 different names in existing literature. For now, etiology remains unclear, but it belongs to group of seronegative spondylarthropathies. Therapy of SAPHO includes NSAIL, glucocorticosteroids, disease modifying anthireumatic drugs (DMARD), antibiotics, bifosfonatos, and anti TNF - alfa drugs with variable success. Case outline: Patient P.Z, 47 age, female, comes in the hospital, because of pain in anterior chest, with propagation in right arm, end morning stiffness in sacral part, which passes short after. Also, with recidivant pustules on the palms, bilaterally, which precedes itch. Bone scintigraphy was performed: There is a clear increasing binding of radiopharmacs in projection of strenoclavicular joint, and slightly in both shoulders and both knees. HP: Pustulosis palmoplantaris. We introduced in therapy azithromycin in the dose of 500 mg, two times weekly, for 16 weeks. Patient, one year after, is without relapses of arthritis and skin lesions. Conclusion: This report has goal, to get more knowledge about this rare disease, and to be easier for recognition. Also we want to introduce other physicians, of varying specialities, like orthopaedics, and other surgeries, with this disease, not only rheumatologists, dermatologists, and pediatrics

Arthritis follows an acute urogenital or intestinal: Reiters disease

Arthritis following dyzentery or urethritis was mentioned before our era and later by many others. In 1818 Benjamin Brodie described 5 patients with typical 'Reiters disease': urethritis, conjunctivitis, arthritis. Many diagnostic criteria for Reiters disease / reactive arthritis have been proposed for practical purpose the most acceeptable is the folowing one: posturethritic or postenterocolitic arthritis is Reiters disease / reactive arthritis. The findings of Chlamydiy from the synovia or in the synovial fluid of itients with RD suggest that arthritis may be of infective but not of reactive origin

Poor life habits: Risk factors for formation osteoporosis

The use of bone density measurements is of central importance for diagnosis, prognosis end the assessment of treatment of patients with osteoorosis. Risk factors are variables which significantly change expected absolute risk, that is, the probability of variable disease in a certain population. Aging and smoking are the most common listed risk factors for the development of osteoporosis. The aim of our work was to confirm the most common risk factors for osteoporosis. In our research work has processed a total of 88 smokers were divided into groups according to the number of cigarettes smoked and the length of smokers. Results showed that risk factors: poor life habits (smoking and use of coffee), are significantly represented on patients with osteoporosis. In order to timely implement treatment, we concluded based on the results, that there is a need actively look for presence of risk factors responsible for osteoporosis in our patients