Mechanics of plastic-aluminum composite I-beams, The

2014 Spring.Includes bibliographical references.This thesis presents an initial investigation of the mechanics of I-beams developed with plastic-aluminum composite technology. Plastic-aluminum composites in structural beam/frame/truss elements are a relatively new concept that has seen little, if any, application in modern construction. This technology has considerable potential to add innovative choices to the array of materials currently available in the construction industry. Several new tests were designed and performed on different portions of the beams, including Push-Through and Knit-Line Pull tests, and tensile tests per ASTM D638-10. The results of these tests showed increased strength with an increase of talc filler content and also showed that the addition of a metal deactivator additive to the plastic results in a slight increase in strength. Duration of Load tests were performed per ASTM D7031-04 and none of the beams tested exhibit tertiary creep. The I-beams investigated here use an internal shear connector (deboss) which acts as a mechanical fastener between the aluminum and the flange plastic. A numerical finite element model was developed in ABAQUS to better understand the underlying physics of the deboss and was compared with a Push-Through test specimen. The results from the model closely match experimental results and the model can be used to predict within 10% the load per deboss region that can be resisted before the plastic begins to yield and extensively deform. This model can be used for differing deboss geometries and any plastic with known material properties. Overall, the results of this research support potential future research involving a more in-depth investigation of this innovative, new class of material technology for use as a structural material

Ergonomics for occupational therapy practitioners

“Ergonomics for Occupational Therapy Practitioners” (EOTP) is an on-demand, on-line course for occupational therapy practitioners (OTPs), as well as other therapy professionals. As many OTPs had limited exposure to ergonomics in their academic education (Fisher, 2019), EOTP is intended to equip them for ergonomic practice. This 10-module on-line course provides ergonomic principles and application for a variety of environments, leveraging adult learning theory and evidence-based curriculum design. The program’s ultimate goal is to increase the number of OTPs working in the area of ergonomics by increasing their knowledge of and confidence in this distinct practice area

Free vs fee: Virtual meetings and online training

Doing more with less is a veritable mantra these days. Yet there are important questions to be answered: When is free good enough? How free is free? When should you buy ? Tools like Adobe Connect, Skype, Captivate, Camtasia, and Jing run the gamut of cost and ease of use while often accomplishing similar tasks in terms of interacting virtually and recording online content. In the first part of this session, learn about these tools which can expand the reach of your meetings and training sessions. We will compare and contrast these tools and focus on why you would use one over the other. During the second part, play the part of the decision-maker through scenarios and case studies. Learn techniques to think critically about these types of tools in the ever changing Library technology landscape today. ABOUT THE PRESENTERS: Kate Peterson is Information Literacy Librarian and Kirsten Clark is Government Information and Regional Depository Librarian at the University of Minnesota Libraries - Twin Citie

Vimentin Diversity in Health and Disease

Vimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn’s disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins. Together with the observation that different domains of vimentin might have evolved under different selection pressures that defined distinct biological functions for different parts of the protein, the many diverse variants of vimentin might be the cause of its functional diversity. A number of review articles have focussed on the biology and medical aspects of intermediate filament proteins without particular commitment to vimentin, and other reviews have focussed on intermediate filaments in an in vitro context. In contrast, the present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentin knockout animals. Our aim is to provide a comprehensive overview of the current understanding of the many diverse aspects of vimentin, from biochemical, mechanical, cellular, systems biology and medical perspectives

An observational study of associations among maternal fluids during parturition, neonatal output, and breastfed newborn weight loss

<p>Abstract</p> <p>Background</p> <p>Newborn weight measurements are used as a key indicator of breastfeeding adequacy. The purpose of this study was to explore non-feeding factors that might be related to newborn weight loss. The relationship between the intravenous fluids women receive during parturition (the act of giving birth, including time in labour or prior to a caesarean section) and their newborn's weight loss during the first 72 hours postpartum was the primary interest.</p> <p>Methods</p> <p>In this observational cohort study, we collected data about maternal oral and IV fluids during labour or before a caesarean section. Participants (n = 109) weighed their newborns every 12 hours for the first three days then daily to Day 14, and they weighed neonatal output (voids and stools) for three days.</p> <p>Results</p> <p>At 60 hours (nadir), mean newborn weight loss was 6.57% (SD 2.51; n = 96, range 1.83-13.06%). When groups, based on maternal fluids, were compared (≤1200 mls [n = 21] versus > 1200 [n = 53]), newborns lost 5.51% versus 6.93% (p = 0.03), respectively. For the first 24 hours, bivariate analyses show positive relationships between a) neonatal output and percentage of newborn weight lost (r(96) = 0.493, p < 0.001); and b) maternal IV fluids (final 2 hours) and neonatal output (r(42) = 0.383, p = 0.012). At 72 hours, there was a positive correlation between grams of weight lost and all maternal fluids (r(75) = 0.309, p = 0.007).</p> <p>Conclusions</p> <p>Timing and amounts of maternal IV fluids appear correlated to neonatal output and newborn weight loss. Neonates appear to experience diuresis and correct their fluid status in the first 24 hours. We recommend a measurement at 24 hours, instead of birth weight, for baseline when assessing weight change. Because practices can differ between maternity settings, we further suggest that clinicians should collect and analyze data from dyads in their care to determine an optimal baseline measurement.</p

Nonclassical binding of formylated peptide in crystal structure of the MHC class lb molecule H2-M3

AbstractH2-M3 is a class Ib MHC molecule of the mouse with a 104-fold preference for binding N-fonmylated peptides. To elucidate the basis of this unusual specificity, we expressed and crystallized a soluble form of M3 with a fonnylated nonamer peptide, fMYFINILTL, and determined the structure by X-ray crystallography. M3, refined at 2.1A˚resolution, resembles class la MHC molecules in its overall structure, but differs in the peptide-binding groove. The A pocket, which usually accommodates the free N-terminus of a bound peptide, is closed, and the peptide Is shifted one residue, such that the P1 side chain is lodged in the B pocket. The formyl group Is coordinated by His-9 and a bound water on the floor of the groove

On the Zero-Point Energy of a Conducting Spherical Shell

The zero-point energy of a conducting spherical shell is evaluated by imposing boundary conditions on the potential, and on the ghost fields. The scheme requires that temporal and tangential components of perturbations of the potential should vanish at the boundary, jointly with the gauge-averaging functional, first chosen of the Lorenz type. Gauge invariance of such boundary conditions is then obtained provided that the ghost fields vanish at the boundary. Normal and longitudinal modes of the potential obey an entangled system of eigenvalue equations, whose solution is a linear combination of Bessel functions under the above assumptions, and with the help of the Feynman choice for a dimensionless gauge parameter. Interestingly, ghost modes cancel exactly the contribution to the Casimir energy resulting from transverse and temporal modes of the potential, jointly with the decoupled normal mode of the potential. Moreover, normal and longitudinal components of the potential for the interior and the exterior problem give a result in complete agreement with the one first found by Boyer, who studied instead boundary conditions involving TE and TM modes of the electromagnetic field. The coupled eigenvalue equations for perturbative modes of the potential are also analyzed in the axial gauge, and for arbitrary values of the gauge parameter. The set of modes which contribute to the Casimir energy is then drastically changed, and comparison with the case of a flat boundary sheds some light on the key features of the Casimir energy in non-covariant gauges.Comment: 29 pages, Revtex, revised version. In this last version, a new section has been added, devoted to the zero-point energy of a conducting spherical shell in the axial gauge. A second appendix has also been include

Measurement of CP violation at a Neutrino Factory

The prospects of measuring CP violation in the leptonic sector using the intense neutrino beams arising from muon decay in the straight sections of a muon accumulator ring (the so-called neutrino factory) are discussed.Comment: Invited talk given at the CP2000 Conference in Ferrara, September, 200