You Can\u27t Always Get What You Want : The Territorial Scope of an Independent Quebec

In Reference Re Secession of Quebec, the Court identified Quebec\u27s borders as a critical issue in any secession negotiation. Canadian constitutional law requires changes to existing borders, particularly if the Aboriginal communities of Ungava maintain their opposition to becoming part of an independent Quebec, for three reasons. First, an independent Quebec has no right to territory gained in 1898 and 1912 because those territories were granted on the condition that Quebec remain in the federation. Second, the existence of constitutionally entrenched fiduciary obligations owed by the Crown to Quebec\u27s Aboriginal peoples gives the latter a veto over a constitutional amendment that would transform provincial borders into international borders. Finally, the principle of federalism mandates that a constitutional amendment affecting the sovereignty of Aboriginal peoples, who comprise an effective third sovereign tier in Canada\u27s federal structure, requires the consent of those Aboriginal peoples

Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron

Bacteroides thetaiotaomicron is a dominant member of the human intestinal microbiome. The genome of this anaerobe encodes more than 100 proteolytic enzymes, the majority of which have not been characterized. In the present study, we have produced and purified recombinant dipeptidyl peptidase III (DPP III) from B. thetaiotaomicron for the purposes of biochemical and structural investigations. DPP III is a cytosolic zinc-metallopeptidase of the M49 family, involved in protein metabolism. The biochemical results for B. thetaiotaomicron DPP III from our research showed both some similarities to, as well as certain differences from, previously characterised yeast and human DPP III. The 3D-structure of B. thetaiotaomicron DPP III was determined by X-ray crystallography and revealed a two-domain protein. The ligand-free structure (refined to 2.4 Å) was in the open conformation, while in the presence of the hydroxamate inhibitor Tyr-Phe-NHOH, the closed form (refined to 3.3 Å) was observed. Compared to the closed form, the two domains of the open form are rotated away from each other by about 28 degrees. A comparison of the crystal structure of B. thetaiotaomicron DPP III with that of the human and yeast enzymes revealed a similar overall fold. However, a significant difference with functional implications was discovered in the upper domain, farther away from the catalytic centre. In addition, our data indicate that large protein flexibility might be conserved in the M49 family

The Break-up of Yugoslavia and international law

The demise of the former Yugoslavia was brought about by various secessionist movements seeking international recognition of statehood. This book provides a critical analysis from an international law perspective of the break-up of Yugoslavia. Although international recognition was granted to the former Yugoslav republics of Slovenia, Croatia, Bosnia-Hercegovina and Macedonia, the claims of secessionist movements that sought a revision of existing internal federal borders were rejected. The basis upon which the post-secession international borders were accepted in international law involved novel applications of international law principles of self-determination of peoples and uti possidetis. This book traces the developments of these principles, and the historical development of Yugoslavia's internal borders

New Search Requirements Following the Hillpalm v Heaven's Door Decision

10 page(s

Secession in constitutional law

11 page(s

Bangladesh : secession aided by military intervention

3 page(s

Indefeasibility and Overriding Statutes

3 page(s

Republika Srpska Krajina and the right of peoples to self-determination

The collapse of the Berlin Wall witnessed a renaissance for the romantic theory of self-determination in that it underpinned a flurry of claims to statehood, especially in Eastern Europe. Nowhere was this more vividly illustrated than in the Balkan lands of the South Slavs. The fragmentation of Yugoslavia during the early 1990s led again to the great powers of the day focusing their attention on the ‘Eastern Question’s’ latest iteration. In so doing, the disintegration of Yugoslavia became a laboratory for these great powers to reformulate and enforce a new understanding of the right of peoples to self-determination. The declarations of independence of the Yugoslav federal republics of Slovenia and Croatia in June 1991 marked the first formal steps towards the secession of these two republics from Yugoslavia. Croatia’s declaration of independence prompted the recursive secession from Croatia of Republika Srpska Krajina (Krajina) in December 1991. Despite the holding of referenda within defined territorial spaces to establish popular support, both the secession of Croatia from Yugoslavia and Krajina’s secession from Croatia were instances of statehood based upon the ‘romantic’ theory of self-determination. The recognition of Croatia’s independence and the denial of Krajina’s independence amounted to an application of the romantic theory of self-determination for the Croat people in Croatia and its denial in the case of Croatia’s Serbs. Against this background, Krajina’s claim to independence based upon the romantic theory of self-determination could only have succeeded if it had had the support of a state with the military strength and influence to maintain and, if necessary, defend Krajina until such time as her independence was formally recognized

Post-secession international borders: a critical analysis of the opinions of the Badinter Arbitration Commission

27 page(s