7,208 research outputs found
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The Blue Obelisk Community
Poster presented at the VSMF symposium held at the Unilever Centre on 2011-01-17The Internet has brought together a group of chemists who are driven by wanting to do things better, but are frustrated with the Closed systems that chemists currently have to work with. they share a belief in the concepts of Open Data, Open Standards and Open Source. And they express this in software, data, algorithms, specifications, tutorials, demonstrations, articles and anything that helps get the message across. [http://www.blueobelisk.org/
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Engineering Polymer Informatics
The poster describes a strategy of for the development of polymer informatics. In particular, the development of polymer markup language, a polymer ontology and natural language processing tools for polymer literature
Automated Coronal Hole Identification via Multi-Thermal Intensity Segmentation
Coronal holes (CH) are regions of open magnetic fields that appear as dark
areas in the solar corona due to their low density and temperature compared to
the surrounding quiet corona. To date, accurate identification and segmentation
of CHs has been a difficult task due to their comparable intensity to local
quiet Sun regions. Current segmentation methods typically rely on the use of
single EUV passband and magnetogram images to extract CH information. Here, the
Coronal Hole Identification via Multi-thermal Emission Recognition Algorithm
(CHIMERA) is described, which analyses multi-thermal images from the
Atmospheric Image Assembly (AIA) onboard the Solar Dynamics Observatory (SDO)
to segment coronal hole boundaries by their intensity ratio across three
passbands (171 \AA, 193 \AA, and 211 \AA). The algorithm allows accurate
extraction of CH boundaries and many of their properties, such as area,
position, latitudinal and longitudinal width, and magnetic polarity of
segmented CHs. From these properties, a clear linear relationship was
identified between the duration of geomagnetic storms and coronal hole areas.
CHIMERA can therefore form the basis of more accurate forecasting of the start
and duration of geomagnetic storms
Representation and use of chemistry in the global electronic age.
We present an overview of the current state of public semantic chemistry and propose new approaches at a strategic and a detailed level. We show by example how a model for a Chemical Semantic Web can be constructed using machine-processed data and information from journal articles.This manuscript addresses questions of robotic access to data and its automatic re-use, including the role of Open Access archival of data. This is a pre-refereed preprint allowed by the publisher's (Royal Soc. Chemistry) Green policy. The author's preferred manuscript is an HTML hyperdocument with ca. 20 links to images, some of which are JPEgs and some of which are SVG (scalable vector graphics) including animations. There are also links to molecules in CML, for which the Jmol viewer is recommended. We susgeest that readers who wish to see the full glory of the manuscript, download the Zipped version and unpack on their machine. We also supply a PDF and DOC (Word) version which obviously cannot show the animations, but which may be the best palce to start, particularly for those more interested in the text
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Cortisol levels in response to starting school in children at increased risk for social phobia
Background: Research on depression has identified hyperactivity of the HPA axis as a
potential contributory factor to the intergenerational transmission of affective symptoms. However,
this has not yet been examined in the context of social phobia. The current study compared HPA axis
activity in response to a universal social stressor (starting school) in children of 2 groups of women:
one with social phobia and one with no history of anxiety (comparison group). To determine specificity
of effects of maternal social phobia, a third group of children were also examined whose mothers had
generalised anxiety disorder (GAD).
Method: Children provided salivary cortisol samples in the morning, afternoon and at bedtime across 3
time-blocks surrounding the school start: a month before starting school (baseline), the first week at
school (stress response), and the end of the first school term (stress recovery). Child behavioural
inhibition at 14 months was also assessed to explore the influence of early temperament on later stress
responses.
Results: All children displayed an elevation in morning and afternoon cortisol from baseline during the
first week at school, which remained elevated until the end of the first term. Children in the social
phobia group, however, also displayed an equivalent elevation in bedtime cortisol, which was not
observed for comparison children or for children of mothers with GAD. Children in the social phobia
group who were classified as 'inhibited' at 14 months displayed significantly higher afternoon cortisol
levels overall.
Summary: A persistent stress response to school in the morning and afternoon is typical for all
children, but children of mothers with social phobia also display atypical elevations in evening cortisol
levels when at school - signalling long-term disruption of the circadian rhythm in HPA axis activity.
This is the first study to report HPA axis disruption in children at risk of developing social phobia, and
future research should aim to determine whether this represents a pathway for symptom
development, taking early temperament into account
Investigating the relationship between material properties and laser-induced damage threshold of dielectric optical coatings at 1064 nm
The Laser Induced Damage Threshold (LIDT) and material properties of various multi-layer amorphous dielectric
optical coatings, including Nb2O5, Ta2O5, SiO2, TiO2, ZrO2, AlN, SiN, LiF and ZnSe, have been studied. The coatings
were produced by ion assisted electron beam and thermal evaporation; and RF and DC magnetron sputtering at Helia
Photonics Ltd, Livingston, UK. The coatings were characterized by optical absorption measurements at 1064 nm by
Photothermal Common-path Interferometry (PCI). Surface roughness and damage pits were analyzed using atomic force
microscopy. LIDT measurements were carried out at 1064 nm, with a pulse duration of 9.6 ns and repetition rate of 100
Hz, in both 1000-on-1 and 1-on-1 regimes. The relationship between optical absorption, LIDT and post-deposition heattreatment
is discussed, along with analysis of the surface morphology of the LIDT damage sites showing both coating
and substrate failure
Mining chemical information from Open patents
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.Abstract Linked Open Data presents an opportunity to vastly improve the quality of science in all fields by increasing the availability and usability of the data upon which it is based. In the chemical field, there is a huge amount of information available in the published literature, the vast majority of which is not available in machine-understandable formats. PatentEye, a prototype system for the extraction and semantification of chemical reactions from the patent literature has been implemented and is discussed. A total of 4444 reactions were extracted from 667 patent documents that comprised 10 weeks' worth of publications from the European Patent Office (EPO), with a precision of 78% and recall of 64% with regards to determining the identity and amount of reactants employed and an accuracy of 92% with regards to product identification. NMR spectra reported as product characterisation data are additionally captured.Peer Reviewe
Tau Aggregation Inhibitor Therapy : An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease
ACKNOWLEDGMENTS We thank patients and their caregivers for their participation in the study and are indebted to all the investigators involved in the study, particularly Drs. Douglas Fowlie and Donald Mowat for their helpful contributions to the clinical execution of the study in Scotland. We thank Sharon Eastwood, Parexel, for assistance in preparing initial drafts of the manuscript. We acknowledge constructive comments provided by Professors G. Wilcock and S. Gauthier on drafts of the article. CMW, CRH, and JMDS are officers of, and hold beneficial interests in, TauRx Therapeutics. RTS, PB, KK, and DJW are paid consultants to TauRx Therapeutics. The study was financed entirely by TauRx TherapeuticsPeer reviewedPublisher PD
Towards Health Informatics 2.0: Blogs, Podcasts and Web 2.0 Applications in Nursing and Health Informatics Education and Professional Collaboration
Health professionals and students are expected to be proficient in basic information technology so as to mitigate error, communicate effectively, manage information and collaborate with peers. Web 2.0 applications such as blogs, podcasts and wikis are social networking tools that may enhance health professionals\u27 development of such skills. As Web 2.0 application use by health professionals is in its infancy, the purpose of this paper is to present examples of the use of such tools that hold potential for online and mobile information dissemination, knowledge building in education, and professional collaboration. Examples based in a collaborative model of virtual conference interaction, and in the use of blogs and podcasts within nursing education, are discussed. The paper concludes by seeking to promote debate on the possible development of Web 2.0 tools specific to health informatics, and so developing the next generation of health informatics, \u27Health Informatics 2.0\u27
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