Formation and evolution of clumpy tidal tails around globular clusters

We present some results of numerical simulations of a globular cluster orbiting in the central region of a triaxial galaxy on a set of 'loop' orbits. Tails start forming after about a quarter of the globular cluster orbital period and develop, in most cases, along the cluster orbit, showing clumpy substructures as observed, for example, in Palomar 5. If completely detectable, clumps can contain about 7,000 solar masses each, i.e. about 10% of the cluster mass at that epoch. The morphology of tails and clumps and the kinematical properties of stars in the tails are studied and compared with available observational data. Our finding is that the stellar velocity dispersion tends to level off at large radii, in agreement to that found for M15 and Omega Centauri.Comment: LaTeX 2e, uses AASTeX v5.x, 40 pages with 18 figures. Submitted to The Astronomical Journa

Plasduino: an inexpensive, general purpose data acquisition framework for educational experiments

Based on the Arduino development platform, Plasduino is an open-source data acquisition framework specifically designed for educational physics experiments. The source code, schematics and documentation are in the public domain under a GPL license and the system, streamlined for low cost and ease of use, can be replicated on the scale of a typical didactic lab with minimal effort. We describe the basic architecture of the system and illustrate its potential with some real-life examples.Comment: 11 pages, 10 figures, presented at the XCIX conference of the Societ\`a Italiana di Fisic

Numerical Assessment on the Influence of Engine Calibration Parameters on Innovative Piston Bowls Designed for Light-Duty Diesel Engines

The optimization of the piston bowl design has been shown to have a great potential for air–fuel mixing improvement, leading to significant fuel consumption and pollutant emissions reductions for diesel engines. With this aim, a conventional re-entrant bowl for a 1.6 L light-duty diesel engine was compared with two innovative piston designs: a stepped-lip bowl and a radial-bumps bowl. The potential benefits of these innovative bowls were assessed through 3D-CFD simulations, featuring a calibrated spray model and detailed chemistry. To analyse the impact of these innovative designs, two different engine operating conditions were scrutinized, corresponding to the rated power and a partial load, respectively. Under the rated power engine operating condition, a start of injection sensitivity was then carried out to assess the optimal spray–wall interaction. Results highlighted that, thanks to optimal injection phasing, faster mixing-controlled combustion could be reached with both the innovative designs. Moreover, the requirements in terms of swirl were also investigated, and a higher swirl ratio was found to be necessary to improve the mixing process, especially for the radial-bumps design. Finally, at part-load operating conditions, different exhaust gas recirculation (EGR) rates were analysed for two injection pressure levels. The stepped-lip and radial-bumps bowls highlighted reduced indicated specific fuel consumption (ISFC) and soot emissions values over different rail pressure levels, guaranteeing NOx control thanks to the higher EGR tolerance compared with the re-entrant bowl. The results suggested the great potential of the investigated innovative bowls for improving efficiency and reducing emissions, thus paving the way for further possible optimization through the combination of these designs

Numerical Assessment of Additive Manufacturing-Enabled Innovative Piston Bowl Design for a Light-Duty Diesel Engine Achieving Ultra-Low Engine-Out Soot Emissions

The design of diesel engine piston bowls plays a fundamental role in the optimization of the combustion process, to achieve ultra-low soot emissions. With this aim, an innovative piston bowl design for a 1.6-liter light-duty diesel engine was developed through a steel-based additive manufacturing (AM) technique, featuring both a sharp step and radial bumps in the inner bowl rim. The potential benefits of the proposed hybrid bowl were assessed through a validated three-dimensional computational fluid dynamics (3D-CFD) model, including a calibrated spray model and detailed chemistry. Firstly, the optimal spray targeting was identified for the novel hybrid bowl over different injector protrusions and two swirl ratio (SR) levels. Considering the optimal spray targeting, an analysis of the combustion process was carried out over different engine working points, both in terms of flame-wall interaction and soot formation. At rated power engine operating conditions, the hybrid bowl highlighted faster mixing-controlled combustion due to the reduced flame-to-flame interaction and the higher air entrainment into the flame front. At partial-load operating points, the hybrid bowl showed a remarkable soot reduction in comparison with the re-entrant bowl due to a more intense soot oxidation rate in the late combustion phase. Moreover, for the hybrid bowl, a robust Exhaust Gas Recirculation (EGR) tolerance was highlighted, leading to a flat soot-brake-specific oxides of nitrogen (BSNOx) trade-off. At constant BSNOx, a 70% soot reduction was achieved without any detrimental effect on fuel consumption, suggesting the high potential of the proposed innovative bowl for soot attenuation

Swab test in biological fluids as predictor of COVID-19 transmission risk during surgery: a prospective cross-sectional study from an Italian COVID center

Background The contamination of body fluids by Severe Acute Respiratory Syndrome Coronavirus 2 during surgery is current matter of debate in the scientific literature concerning CoronaVIrus Disease 2019. Surgical guidelines were published during the first wave of the COVID-19 pandemic and recommended to avoid laparoscopic surgery as much as possible, in fear that the chimney effect of high flow intraperitoneal gas escape during, and after, the procedure would increase the risk of viral transmission. Aim The aim of this study was to evaluate the possibility of SARS-CoV-2 transmission during surgery by searching for viral RNA in serial samplings of biological liquids. Methods This is a single center prospective cross-sectional study. We used a real-time reverse transcriptase (RT) polymerase chain reaction (PCR) test to perform swab tests for the qualitative detection of nucleic acid from SARS-CoV-2 in abdominal fluids, during emergency surgery and on the first post-operative day. In the case of thoracic surgery, we performed a swab test of pleural fluids during chest drainage placement as well as on the first post-operative day. Results A total of 20 samples were obtained: 5 from pleural fluids, 13 from peritoneal fluids and two from biliary fluid. All 20 swabs performed from biological fluids resulted negative for SARS-CoV-2 RNA detection. Conclusion To date, there is no scientific evidence of possible contagion by laparoscopic aerosolization of SARS-CoV-2, neither is certain whether the virus is effectively present in biological fluids

GLP-1 receptor agonists and renal outcomes in patients with diabetes mellitus type 2 and diabetic kidney disease: State of the art

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are highly effective in improving glycaemic control either as monotherapy or in combination with other hypoglycaemic drugs, and have low incidence of side effects, such as hypoglycaemia, nausea and weight gain, thus increasing patients' adherence to therapy. Methods: In this review we report the most recent studies demonstrating the beneficial effects of GLP-1RAs on renal outcomes, and also discuss the direct and indirect mechanisms through which they confer kidney protection. Finally, we discuss the metabolic and anti-inflammatory effects of GLP-1RAs in diabetic patients with COVID-19 disease. Results: GLP-1RAs have a nephroprotective action, which is expressed through both indirect (improvement of blood pressure and glycaemic control, weight loss) and direct (restoration of normal intrarenal haemodynamics, prevention of ischaemic and oxidative damage) effects. They have shown also metabolic and anti-inflammation beneficial effects in patients with COVID-19 disease. Conclusions: GLP-1RAs prevent albuminuria and slow the decline of renal function towards end stage renal disease in patients with diabetic kidney disease. They might be an opportunity to break the typical inflammation processes of COVID-19 disease

Numerical and optical soot characterization through 2-color pyrometry technique for an innovative diesel piston bowl design

The development of innovative diesel piston bowl designs has shown significant improvement of the near-wall flame evolution, resulting in lower fuel consumption and engine-out soot emissions. With this aim, a novel hybrid piston bowl for a 1.6 L light-duty diesel engine was designed, coupling a sharp-stepped bowl and radial-bumps in the inner bowl rim. The effects of the proposed hybrid bowl were analysed through both single-cylinder optical engine and 3D-CFD models, which feature a detailed chemical kinetic mechanism and the Particulate Mimic (PM) soot model. The 2-color pyrometry optical technique was adopted to obtain the optical soot density (KL) and the temperature of the soot surface. Then, a line-of-sight integration of the numerical soot distribution was adopted to obtain a planar KL distribution, which is directly comparable with the experimental KL images. The results showed a good agreement in terms of soot distribution between 3D-CFD and experiments, confirming the high prediction capabilities of the developed numerical methodology. The synergetic application of numerical and optical techniques highlighted that the hybrid bowl strongly mitigates the flame-to-flame interaction with respect to a conventional re-entrant bowl, leading to lower soot formation in the flame collision area. Moreover, faster flame propagation toward the cylinder axis is highlighted with a consequent higher soot oxidation rate in the late combustion phase

High resolution crystal structures of the <i>Cerebratulus lacteus</i> mini-Hb in the unligated and carbomonoxy states

The nerve tissue mini-hemoglobin from Cerebratulus lacteus (CerHb) displays an essential globin fold hosting a protein matrix tunnel held to allow traffic of small ligands to and from the heme. CerHb heme pocket hosts the distal TyrB10/GlnE7 pair, normally linked to low rates of O2 dissociation and ultra-high O2 affinity. However, CerHb affinity for O2 is similar to that of mammalian myoglobins, due to a dynamic equilibrium between high and low affinity states driven by the ability of ThrE11 to orient the TyrB10 OH group relative to the heme ligand. We present here the high resolution crystal structures of CerHb in the unligated and carbomonoxy states. Although CO binds to the heme with an orientation different from the O2 ligand, the overall binding schemes for CO and O2 are essentially the same, both ligands being stabilized through a network of hydrogen bonds based on TyrB10, GlnE7, and ThrE11. No dramatic protein structural changes are needed to support binding of the ligands, which can freely reach the heme distal site through the apolar tunnel. A lack of main conformational changes between the heme-unligated and -ligated states grants stability to the folded mini-Hb and is a prerequisite for fast ligand diffusion to/from the heme

Merging of globular clusters within inner galactic regions. I. Do they survive the tidal interaction?

The main topic of this paper is the investigation of the modes of interaction of globular clusters (GCs) moving in the inner part of a galaxy. This is tackled by means of high-resolution N-body simulations, whose first results are presented in this article. Our simulations dealt with primordial very massive (order of 10^7 solar masses) GCs that were able to decay, because of dynamical friction, into the inner regions of triaxial galaxies on a time much shorter than their internal relaxation time. To check the disruptive role of both tidal forces and GC-GC collisions, we maximised the tidal interaction considering GCs on quasi-radial orbits. The available CPU resources allowed us to follow 8 oscillations of the GCs along their orbits and the main findings are: i) clusters with an initial high enough King concentration parameter (c>=1.2), preserve up to 50% of their initial mass; ii) the inner density distribution of the survived clusters keep a King model profile; iii) GC-GC collisions have a negligible effect with respect to that caused by the passage through the galactic center; iv) the orbital energy dissipation due to the tidal interaction is of the same order of that caused by dynamical friction; v) complex sub-structures like "ripples" and "clumps" formed, as observed around real clusters. These findings support the validity of the hypothesis of merging of GCs in the galactic central region, with modes that deserve further careful investigations.Comment: LaTeX 2e, AASTeX v5.x, 23 pages with 14 figures. Accepted for publication on the Astrophysical Journal. Final version with major change

The treatment of achalasia patients with esophageal varices: an international study

Background: Treatment options for achalasia include endoscopic and surgical techniques that carry the risk of esophageal bleeding and perforation. The rare coexistence of esophageal varices has only been anecdotally described and treatment is presumed to carry additional risk. Methods: Experience from physicians/surgeons treating this rare combination of disorders was sought through the International Manometry Working Group. Results: Fourteen patients with achalasia and varices from seven international centers were collected (mean age 61 9 years). Five patients were treated with botulinum toxin injections (BTI), four had dilation, three received peroral endoscopic myotomy (POEM), one had POEM then dilation, and one patient underwent BTI followed by Heller’s myotomy. Variceal eradication preceded achalasia treatment in three patients. All patients experienced a significant symptomatic improvement (median Eckardt score 7 vs 1; p < 0.0001) at 6 months follow-up, with treatment outcomes resembling those of 20 non- cirrhotic achalasia patients who underwent similar therapy. No patients had recorded complications of bleeding or perforation. Conclusion: This study shows an excellent short-term symptomatic response in patients with esophageal achalasia and varices and demonstrates that the therapeutic outcomes and complications, other than transient encephalopathy in both patients who had a portosystemic shunt, did not differ to disease-matched patients without varices