La red aeroportuaria y la organización sanitaria de la provincia de Buenos Aires

El presente trabajo analiza el impacto de la infraestructura aeroportuaria de la provincia de Buenos Aires en la organización sanitaria de la Provincia de Buenos Aires, se desarrolla desde la introducción a la asistencia del accidentado describiendo las premisas fundamentales del tratamiento, pasando luego por la descripción de las regiones sanitarias y la formulación de las hipótesis para el análisis de la red. La Provincia de Buenos Aires, en materia de transporte ha definido una red de aeródromos y helipuertos que la dota en toda su extensión de infraestructura aeroportuaria en condiciones de vincular a los distintos municipios entre sí, y a estos, con la capital provincial y la ciudad de Buenos Aires. Sobre las base de las hipótesis planteadas y utilizando el tiempo total de respuesta -tiempo de viaje al punto crítico de la región más el tiempo desde este punto al hospital- como parámetro de evaluación, se abordan tres casos de estudio: el primero, considera que los municipios más críticos afectados por la distancia son atendidos por otra región, en el segundo a través de la formulación de nuevas estrategias de la flota de aeronaves, y el ultimo en la incorporación o adecuación de hospitales en zonas críticas con alta complejidad.This paper analyzes the impact of airport infrastructure, in the province of Buenos Aires, on the health organization of the Province of Buenos Aires, it is developed from the introduction to the assistance of the victim describing the basic principles of treatment, proceeding after to the description of health regions and the formulation of hypotheses for network analysis . The Province of Buenos Aires, on transport has defined a network of airfields and heliports that gives full extent of airport infrastructure able to link together the different municipalities, and these, with the provincial capital and the city of Buenos Aires. On the basis of the hypotheses and using the total response time - travel time to the critical point of the region plus the time from this point to the hospital as a parameter of evaluation addresses three case studies : the first considers most critical municipalities affected by the distance are served by a different region, the second one through the development of new strategies for the aircraft fleet, and the last in the incorporation or adequacy of hospitals with high complexity in critical areas.Trabajo publicado en Actas del Cuarto Congreso de la Red Iberoamericana de Investigación en Transporte Aéreo. La Plata, Universidad Nacional de La Plata, 2013.Grupo de Transporte Aéreo - Grupo de Ingeniería Aplicada a la Industri

La red aeroportuaria y la organización sanitaria de la provincia de Buenos Aires

El presente trabajo analiza el impacto de la infraestructura aeroportuaria de la provincia de Buenos Aires en la organización sanitaria de la Provincia de Buenos Aires, se desarrolla desde la introducción a la asistencia del accidentado describiendo las premisas fundamentales del tratamiento, pasando luego por la descripción de las regiones sanitarias y la formulación de las hipótesis para el análisis de la red. La Provincia de Buenos Aires, en materia de transporte ha definido una red de aeródromos y helipuertos que la dota en toda su extensión de infraestructura aeroportuaria en condiciones de vincular a los distintos municipios entre sí, y a estos, con la capital provincial y la ciudad de Buenos Aires. Sobre las base de las hipótesis planteadas y utilizando el tiempo total de respuesta -tiempo de viaje al punto crítico de la región más el tiempo desde este punto al hospital- como parámetro de evaluación, se abordan tres casos de estudio: el primero, considera que los municipios más críticos afectados por la distancia son atendidos por otra región, en el segundo a través de la formulación de nuevas estrategias de la flota de aeronaves, y el ultimo en la incorporación o adecuación de hospitales en zonas críticas con alta complejidad.This paper analyzes the impact of airport infrastructure, in the province of Buenos Aires, on the health organization of the Province of Buenos Aires, it is developed from the introduction to the assistance of the victim describing the basic principles of treatment, proceeding after to the description of health regions and the formulation of hypotheses for network analysis . The Province of Buenos Aires, on transport has defined a network of airfields and heliports that gives full extent of airport infrastructure able to link together the different municipalities, and these, with the provincial capital and the city of Buenos Aires. On the basis of the hypotheses and using the total response time - travel time to the critical point of the region plus the time from this point to the hospital as a parameter of evaluation addresses three case studies : the first considers most critical municipalities affected by the distance are served by a different region, the second one through the development of new strategies for the aircraft fleet, and the last in the incorporation or adequacy of hospitals with high complexity in critical areas.Trabajo publicado en Actas del Cuarto Congreso de la Red Iberoamericana de Investigación en Transporte Aéreo. La Plata, Universidad Nacional de La Plata, 2013.Grupo de Transporte Aéreo - Grupo de Ingeniería Aplicada a la Industri

Antimutagenic compounds and their possible mechanisms of action

Mutagenicity refers to the induction of permanent changes in the DNA sequence of an organism, which may result in a heritable change in the characteristics of living systems. Antimutagenic agents are able to counteract the effects of mutagens. This group of agents includes both natural and synthetic compounds. Based on their mechanism of action among antimutagens, several classes of compounds may be distinguished. These are compounds with antioxidant activity; compounds that inhibit the activation of mutagens; blocking agents; as well as compounds characterized with several modes of action. It was reported previously that several antitumor compounds act through the antimutagenic mechanism. Hence, searching for antimutagenic compounds represents a rapidly expanding field of cancer research. It may be observed that, in recent years, many publications were focused on the screening of both natural and synthetic compounds for their beneficial muta/antimutagenicity profile. Thus, the present review attempts to give a brief outline on substances presenting antimutagenic potency and their possible mechanism of action. Additionally, in the present paper, a screening strategy for mutagenicity testing was presented and the characteristics of the most widely used antimutagenicity assays were described

Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

The Ultrastructural Analysis of Scales in Brachypera

WOS: 000343230600004The scales that are external morphological characters in Brachypera Capiomont, 1868 and Hypera Germar, 1817 (Curculionidae: Hyperinae) were examined using light and scanning electron microscope (SEM). Dried museum materials were used in this study. After softening the materials, abdomens were removed to reach elytra. Similarities and differences among the species are discussed. Although the scales look alike under the light microscope, they showed a rather different pattern with SEM. The fine structure of scales was shown to be useful for comparing species

Evaluation of the antimutagenic and anticarcinogenic effects of inulin in vivo

The incidence of colorectal cancer is growing worldwide. The characterization of compounds present in the human diet that can prevent the occurrence of colorectal tumors is vital. The oligosaccharide inulin is such a compound. The aim of this study was to evaluate the antigenotoxic, antimutagenic and anticarcinogenic effects of inulin in vivo. Our study is based on 3 assays that are widely used to evaluate chemoprevention (comet assay, micronucleus assay, and aberrant crypt focus assay) and tests 4 protocols of treatment with inulin (pre-treatment, simultaneous, post-treatment, and pre + continuous). Experiments were carried out in Swiss male mice of reproductive age. In order to induce DNA damage, we used the pro-carcinogenic agent 1,2-dimethylhydrazine. Inulin was administered orally at a concentration of 50 mg/kg body weight following the protocols mentioned above. Inulin was not administered to the control groups. Our data from the micronucleus assay reveal antimutagenic effects of inulin in all protocols. The percentage of inulin-induced damage reduction ranged from 47.25 to 141.75% across protocols. These data suggest that inulin could act through desmutagenic and bio-antimutagenic mechanisms. The anticarcinogenic activity (aberrant crypt focus assay) of inulin was observed in all protocols and the percentages of damage reduction ranged from 55.78 to 87.56% across protocols. Further tests, including human trials, will be necessary before this functional food can be proven to be effective in the prevention and treatment of colon cancer. © FUNPEC-RP

Pre-treatment with glutamine reduces genetic damage due to cancer treatment with cisplatin

ABSTRACT. Cisplatin is an effective antineoplastic drug. However, it provokes considerable collateral effects, including genotoxic and clastogenic activity. It has been reported that a diet rich in glutamine can help inhibit such collateral effects. We evaluated this activity in 40 Swiss Glutamine chemoprevention in vivo mice, distributed into eight experimental groups: G1 -Control group (PBS 0.1 mL/10g body weight); G2 -cisplatin group (cisplatin 6 mg/kg intraperitoneally); G3, G4, G5 -glutamine groups (glutamine at 150, 300, and 600 mg/kg, respectively; orally); G6, G7, G8 -Pre-treatment groups (glutamine at 150, 300, and 600 mg/kg, respectively; orally and cisplatin 6 mg/kg intraperitonially). For the micronucleus assay, samples of blood were collected (before the first use of the drugs at T0, then 24 (T1) and 48 (T2) hours after the first administration). For the comet assay, blood samples were collected only at T2. The damage reduction percentages for the micronucleus assay were 90.0, 47.3, and 37.3% at T1 and 46.0, 38.6, and 34.7% at T2, for G6, G7, and G8 groups, respectively. For the comet assay, the damage reduction percentages were 113.0, 117.4, and 115.0% for G6, G7, and G8, respectively. We conclude that glutamine is able to prevent genotoxic and clastogenic damages caused by cisplatin

Pre-treatment with glutamine reduces genetic damage due to cancer treatment with cisplatin

Cisplatin is an effective antineoplastic drug. However, it provokes considerable collateral effects, including genotoxic and clastogenic activity. It has been reported that a diet rich in glutamine can help inhibit such collateral effects. We evaluated this activity in 40 Swiss mice, distributed into eight experimental groups: G1 - Control group (PBS 0.1 mL/10g body weight); G2 - cisplatin group (cisplatin 6 mg/kg intraperitoneally); G3, G4, G5 - glutamine groups (glutamine at 150, 300, and 600 mg/kg, respectively; orally); G6, G7, G8 - Pre-treatment groups (glutamine at 150, 300, and 600 mg/kg, respectively; orally and cisplatin 6 mg/kg intraperitonially). For the micronucleus assay, samples of blood were collected (before the first use of the drugs at T0, then 24 (T1) and 48 (T2) hours after the first administration). For the comet assay, blood samples were collected only at T2. The damage reduction percentages for the micronucleus assay were 90.0, 47.3, and 37.3% at T1 and 46.0, 38.6, and 34.7% at T2, for G6, G7, and G8 groups, respectively. For the comet assay, the damage reduction percentages were 113.0, 117.4, and 115.0% for G6, G7, and G8, respectively. We conclude that glutamine is able to prevent genotoxic and clastogenic damages caused by cisplatin

Prevention of DNA damage and anticarcinogenic activity of Activia ® in a preclinical model of the Creative Commons Attribution ShareAlike (CC BY-SA) 4.0 License

ABSTRACT. Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia ® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a proven capacity to intestinal regulation in humans. The aim of this study was to evaluate the antigenotoxic, antimutagenic, and anticarcinogenic proprieties of the Activia product, in response to damage caused by 1,2-dimethylhydrazine (DMH) in Swiss mice. Activia does not have shown antigenotoxic activity. However, the percent of DNA damage reduction, evaluated by the antimutagenicity assay, ranged from 69.23 to 96.15% indicating effective chemopreventive action. Activia reduced up to 79.82% the induction of aberrant crypt foci by DMH. Facing the results, it is inferred that Activia facilitates the weight loss, prevents DNA damage and pre-cancerous lesions in the intestinal mucosa

Contrasting patterns of hybridization in large house spiders (Tegenaria atrica Group, Agelenidae)

The integrity of species is not fixed and may vary geographically. Here we investigate the geographic distributions and interactions of species in the Tegenaria atrica group (Araneae: Agelenidae). Detailed mapping of T. saeva and T. gigantea in England and Wales shows them to be broadly allopatric in southern England with a tightly defined, and possibly long-standing, narrow zone of parapatry in central southern England. In the north of England (Yorkshire), by contrast, the species are broadly sympatric as a result of recent range expansions. GIS techniques are used to map the species distributions and to quantify, we believe for the first time, the intimacy of interspecific interactions. The extent and nature of hybridization in these two areas is examined through regression and multivariate analyses of morphology. We show that the relative incidence of hybridization is much greater in Yorkshire than within the parapatric zone in the south. Clear patterns of asymmetric introgression are observed in both northern and southern England, with a greater impact of T. gigantea on T. saeva than vice versa. We find no sign of morphological reproductive character displacement at the zone of parapatry that might indicate reinforcement, although we cannot exclude more subtle effects, for example via cuticular pheromones. The integrity of these two species seems to be breaking down in northern England, a process that might gain momentum as the gene pools become more similar