"Who are you going to call?" Network activation in creative idea generation and elaboration

Considering creativity as a journey beyond idea generation, scholars have theorized that different ties are beneficial in different phases. As individuals usually possess different types of ties, selecting the optimal ties in each phase and changing ties as needed are central activities for creative success. We identify the types of ties (weak or strong) that are helpful in idea generation and idea elaboration, and given this understanding, whether individuals activate ties in each phase accordingly. In an experimental study of individuals conversing with their ties, we provide evidence of the causal effects of weak and strong ties on idea generation and idea elaboration. We also find that individuals do not always activate ties optimally and identify network size and risk as barriers. Our results in a series of studies reveal that individuals with large networks, despite providing more opportunity to activate both strong and weak ties, activate fewer weak ties and are less likely to switch ties across phases than individuals with smaller networks, particularly when creativity is perceived as a high-risk endeavor. Finally, we find that activating the wrong ties leads to either dropping creative ideas or pursuing uncreative ones

Clinical utility of the 2-minute walk test for older adults living in long-term care

Purpose: This study\u27s purposes were to examine the measurement properties of the 2-minute walk test (2MWT), to illustrate the use of reliability coefficients in clinical practice, and to estimate sample size for a subsequent validity study. Method: Sixteen residents of long-term care (LTC; mean age = 87 years) completed two 2MWTs with Rater A and two 2MWTs with Rater B on test days 1 and 2, approximately 1 week apart. On a third test day, subjects completed one trial of the Berg Balance Scale (BBS), timed up-and-go (TUG) test, and 6-minute walk test (6MWT) with Rater A. On 2 other test days, approximately 1 week apart, Rater A administered the 2MWT to five older adults living in a retirement facility. Absolute and relative reliability and concurrent and known-groups validity coefficients were calculated. Results: No main effect for rater, trial, or occasion was found. Test-retest reliability estimates of 0.94 and 0.95 were obtained. The 2MWT demonstrated concurrent validity (r\u3e0.84) with the BBS, TUG, and 6MWT. Comparison of distance walked by LTC and retirement residents showed a difference of 72.9m (95% CI: 44.2, 101.6). The results suggest that 90% of truly stable older adults will display random fluctuations in 2MWT performance within a boundary of 15 m. Conclusion: The 2MWT had sound measurement properties in this sample of LTC residents. Based on our results, 24 subjects would be required for a subsequent hypothesis-testing validity study

Education : the state of the discipline. A survey of education researchers' work, experiences and identities

Education: The State of the Discipline is a major BERA initiative that aims to provide a clear, comprehensive account of the state of education as an academic discipline in universities; as a field of practice; and as a significant and central element of social and political policy in the four nations of the UK. This report is the third publication from the initiative and shares the findings of a survey of education researchers’ perceptions of their work and identities in relation to education research in universities in the UK. The survey intended to provide robust data about the state of education as an academic discipline, and examine the structures and processes that influence opportunity for, and engagement in, research activity for staff working in university education departments

Symbiotic starburst-black hole AGN -- I. Isothermal hydrodynamics of the mass-loaded ISM

Compelling evidence associates the nuclei of active galaxies and massive starbursts. The symbiosis between a compact nuclear starburst stellar cluster and a massive black hole can self-consistently explain the properties of active nuclei. The young stellar cluster has a profound effect on the most important observable properties of active galaxies through its gravity, and by mass injection through stellar winds, supernovae and stellar collisions. Mass injection generates a nuclear ISM which flows under gravitational and radiative forces until it leaves the nucleus or is accreted onto the black hole or accretion disc. The radiative force exerted by the black hole--accretion disc radiation field is not spherically symmetric. This results in complex flows in which regions of inflow can coexist with high Mach number outflowing winds and hydrodynamic jets. We present two-dimensional hydrodynamic models of such nISM flows, which are highly complex and time variable. Shocked shells, jets and explosive bubbles are produced, with bipolar winds driving out from the nucleus. Our results graphically illustrate why broad emission line studies have consistently failed to identify any simple, global flow geometry. The real structure of the flows is _inevitably_ yet more complex.Comment: 51 pages, 85 postscript figures, Latex, using MNRAS macros, to be published in MNRAS. Postscript will full resolution pictures and mpeg simulations available via http://ast.leeds.ac.uk/~rjrw/agn.htm

VLBI Imaging of Luminous Infrared Galaxies: AGN Cores in Mrk231, UGC 5101 & NGC 7469

We report 18cm VLBI continuum imaging observations at 5 mas resolution for UGC 5101, NGC 7469, and Mrk 231, all part of a sample of Luminous Infrared Galaxies which have been shown to have strong VLBI radio cores. The radio morphology of these three systems on VLBI scales is AGN-like, with well-defined ridgelines and high-brightness yet spatially resolved components. The structure and flux densities of these VLBI components are not consistent with starburst generated radio supernovae of the type found in Arp 220. On scales of 100pc the radio continuum in all three objects appears to be dominated by an AGN, not a starburst. Radio emission on larger scales may well originate in a less compact circumnuclear star-forming region. Confirming and extending VLBI imaging of Mrk 231 by Ulvestad et al. (1999), our continuum image shows a triple structure, with a core and two lobes, classifying it as a Compact Symmetric Object (CS0). If the southern (primary) lobe/hot-spot in Mrk 231 is confined by ram pressure, we estimate a lobe advance speed, $v_a \sim 10^{-4}c$, and an age for the jet/compact source, $< 10^6 yr$. We have also imaged the 1667 MHz OH maser emission in Mrk 231, which is extended on scales of 50--100 milliarcsec (40--80 pc) and probably coincides with the inner region of the disk which is seen in CO emission and HI absorption. Among OH megamasers studied at high sensitivity with mas resolution, Mrk 231 is unique in the stringent upper limits placed upon the flux density of compact OH structures of the type found in Arp 220 and other LIGs. It is possible that the circumnuclear environment of Mrk 231 has been sufficiently disrupted by the emergent QSO that the cool, dense clouds necessary for such compact masers no longer exist.Comment: 43 pages, 7 figure

Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth

OBJECTIVE: Low birth weight is associated with an increased risk of type 2 diabetes. The mechanisms underlying this association are unknown and may represent intrauterine programming or two phenotypes of one genotype. The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion or action may predispose to type 2 diabetes and also reduce birth weight, since insulin is a key fetal growth factor. We tested whether common genetic variants that predispose to type 2 diabetes also reduce birth weight. RESEARCH DESIGN AND METHODS: We genotyped single-nucleotide polymorphisms (SNPs) at five recently identified type 2 diabetes loci (CDKAL1, CDKN2A/B, HHEX-IDE, IGF2BP2, and SLC30A8) in 7,986 mothers and 19,200 offspring from four studies of white Europeans. We tested the association between maternal or fetal genotype at each locus and birth weight of the offspring. RESULTS: We found that type 2 diabetes risk alleles at the CDKAL1 and HHEX-IDE loci were associated with reduced birth weight when inherited by the fetus (21 g [95% CI 11-31], P = 2 x 10(-5), and 14 g [4-23], P = 0.004, lower birth weight per risk allele, respectively). The 4% of offspring carrying four risk alleles at these two loci were 80 g (95% CI 39-120) lighter at birth than the 8% carrying none (P(trend) = 5 x 10(-7)). There were no associations between birth weight and fetal genotypes at the three other loci or maternal genotypes at any locus. CONCLUSIONS: Our results are in keeping with the fetal insulin hypothesis and provide robust evidence that common disease-associated variants can alter size at birth directly through the fetal genotype

Sexual selection and the evolution of condition-dependence: an experimental test at two resource levels

Stronger condition-dependence in sexually selected traits is well-documented, but how this relationship is established remains unknown. Moreover, resource availability can shape responses to sexual selection, but resource effects on the relationship between sexual selection and condition-dependence are also unknown. In this study, we directly test the hypotheses that sexual selection drives the evolution of stronger-condition-dependence and that resource availability affects the outcome, by evolving fruit flies (Drosophila melanogaster) under relatively strong or weak sexual selection (through varied sex ratios) and at resource-poor or resource-rich adult diets. We then experimentally manipulated condition via developmental diet and assessed condition-dependence in adult morphology, behavior, and reproduction. We observed stronger condition-dependence in female size in male-biased populations and in female ovariole production in resource-limited populations. However, we found no evidence that male condition-dependence increased in response to sexual selection, or that responses depended on resource levels. These results offer no support for the hypotheses that sexual selection increases male condition-dependence or that sexual selection's influence on condition-dependence is influenced by resource availability. Our study is, to our knowledge, the first experimental test of these hypotheses. If the results we report are general, then sexual selection's influence on the evolution of condition-dependence may be less important than predicted

Control of primary productivity and the significance of photosynthetic bacteria in a meromictic kettle lake.

During 1986 planktonic primary production and controlling factors were investigated in a small (A0 = 11.8 · 103 m2, Zmax = 11.5 m) meromictic kettle lake (Mittlerer Buchensee). Annual phytoplankton productivity was estimated to ca 120 gC · m–2 · a–1 (1,42 tC · lake–1 · a–1). The marked thermal stratification of the lake led to irregular vertical distributions of chlorophylla concentrations (Chla) and, to a minor extent, of photosynthesis (Az). Between the depths of 0 to 6 m low Chla concentrations (< 7 mg · m–3) and comparatively high background light attenuation (kw = 0,525 m–1, 77% of total attenuation due to gelbstoff and abioseston) was found. As a consequence, light absorption by algae was low (mean value 17,4%) and self-shading was absent. Because of the small seasonal variation of Chla concentrations, no significant correlation between Chla and areal photosynthesis (A) was observed. Only in early summer (June–July) biomass appears to influence the vertical distribution of photosynthesis on a bigger scale. Around 8 m depth, low-light adapted algae and phototrophic bacteria formed dense layers. Due to low ambient irradiances, the contribution of these organisms to total primary productivity was small. Primary production and incident irradiance were significantly correlated with each other (r2 = 0.68). Although the maximum assimilation number (Popt) showed a clear dependence upon water temperature (Q10 = 2.31), the latter was of minor importance to areal photosynthesis

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia

Paediatric B-precursor ALL is a highly curable disease, however, treatment resistance in some patients and the long-term toxic effects of current therapies pose the need for more targeted therapeutic approaches. We addressed the cytotoxic effect of JQ1, a highly selective inhibitor against the transcriptional regulators, bromodomain and extra-terminal (BET) family of proteins, in paediatric ALL. We showed a potent in vitro cytotoxic response of a panel of primary ALL to JQ1, independent of their prognostic features but dependent on high MYC expression and coupled with transcriptional downregulation of multiple pro-survival pathways. In agreement with earlier studies, JQ1 induced cell cycle arrest. Here we show that BET inhibition also reduced c-Myc protein stability and suppressed progression of DNA replication forks in ALL cells. Consistent with c-Myc depletion and downregulation of pro-survival pathways JQ1 sensitised primary ALL samples to the classic ALL therapeutic agent dexamethasone. Finally, we demonstrated that JQ1 reduces ALL growth in ALL xenograft models, both as a single agent and in combination with dexamethasone. We conclude that targeting BET proteins should be considered as a new therapeutic strategy for the treatment of paediatric ALL and particularly those cases that exhibit suboptimal responses to standard treatment