Philippe Hamon-Alexandrine Viboud, Dictionnaire thématique du roman de moeurs en France (1814-1914)

Ces volumes poursuivent et complètent une entreprise ambitieuse qu’a déjà consacrée la parution en 2003, par les mêmes auteurs et chez le même éditeur, d’un premier dictionnaire s’intéressant alors à la seule première moitié du xixe siècle. Ainsi que l’indique un texte de présentation qui fournit des indications méthodologiques indispensables à tous qui souhaitent utiliser cet ouvrage, ses auteurs s’adressent à un public informé dont ils souhaitent faciliter les travaux et enrichir les biblio..

Dynamic study of blood-brain barrier closure after its disruption using ultrasound: a quantitative analysis.

International audienceDelivery of therapeutic or diagnostic agents to the brain is majorly hindered by the blood-brain barrier (BBB). Recently, many studies have demonstrated local and transient disruption of the BBB using low power ultrasound sonication combined with intravascular microbubbles. However, BBB opening and closure mechanisms are poorly understood, especially the maximum gap that may be safely generated between endothelial cells and the duration of opening of the BBB. Here, we studied BBB opening and closure under magnetic resonance (MR) guidance in a rat model. First, MR contrast agents (CA) of different hydrodynamic diameters (1 to 65 nm) were employed to estimate the largest molecular size permissible across the cerebral tissues. Second, to estimate the duration of the BBB opening, the CA were injected at various times post-BBB disruption (12 minutes to 24 hours). A T(1) mapping strategy was developed to assess CA concentration at the ultrasound (US) focal point. Based on our experimental data and BBB closure modeling, a calibration curve was obtained to compute the half closure time as a function of CA hydrodynamic diameter. These findings and the model provide an invaluable basis for optimal design and delivery of nanoparticles to the brain

ACR Appropriateness Criteria® Locoregional therapy for resectable oropharyngeal squamous cell carcinomas

BackgroundThere are no level I studies to guide treatment for resectable oropharyngeal squamous cell carcinoma (SCC). Treatment toxicities influence management recommendations. Ongoing investigations are examining deintensified treatments for human papillomavirus (HPV)‐associated oropharyngeal SCC.MethodsThe Appropriateness Criteria panel, using modified Delphi methodology, produced a literature summary, an assessment of treatment recommendations, and cases to illustrate their use.ResultsA multidisciplinary team produces optimum results. Based on HPV status, smoking history, and staging, patients are divided into groups at low, intermediate, and high‐risk of death. In the future, treatment recommendations may be influenced by HPV status, which has changed the epidemiology of oropharyngeal SCC.ConclusionT1 to T2N0M0 resectable oropharyngeal SCC can be treated with surgery or radiation without chemotherapy. Patients with T1‐2N1‐2aM0 disease can receive radiation, chemoradiation, or transoral surgery with neck dissection and appropriate adjuvant therapy. Patients with T1‐2N2b‐3M0 disease should receive chemoradiation or transoral surgery with neck dissection and appropriate adjuvant therapy. Concurrent chemoradiation is preferred for T3 to T4 disease. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1299–1309, 2016Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/133590/1/hed24447.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133590/2/hed24447_am.pd

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

Paris, province pédagogique

International audienc

Jules Lemaitre: « un don d'ubiquité familière »

National audienc

Rostand de guerre

International audienceThis study looks at the conditions under which Rostand wrote and published the poems that were collected in Le Vol de la Marseillaise soon after his death. Starting with an analysis of the discursive situation that was furnished for him during the world war and based on readings of several plays, it shows how Rostand was able to appropriate war discourse and how he found the means to bring it before the public in such a way that he came to be seen as a real national poet.Cette étude s’intéresse aux conditions dans lesquelles Rostand a rédigé et publié les poèmes qui ont été réunis dans Le Vol de la Marseillaise au lendemain de sa disparition. Partant d’une analyse de la situation discursive qui lui a été faite durant le conflit mondial et s’appuyant sur la lecture de plusieurs pièces, l’on montre comment Rostand est parvenu à s’approprier un discours de guerre et s’est donné le moyen de le porter devant le public au point de faire figure de véritable poète national

Le magistère du pédagogue : professeurs de pensée générale et romanciers au tournant du siècle

International audienc

Fernand Vandérem et la querelle des manuels

National audienc

Histoire littéraire et « jeune littérature » (1880-1925)

Comme en témoignent les polémiques qui se développent autour de Lanson et de son œuvre à la veille de l’entrée en guerre, l’institutionnalisation universitaire de l’histoire littéraire est étroitement liée au projet éducatif républicain. Lancées par des proches de Maurras, reformulées par Péguy aussi bien que par Alain, elles mettent en effet au jour que la République fixe à la littérature, vue comme un instrument de socialisation et de moralisation, un devoir civique et patriotique, que l’hi..