Simultaneously-Measured Mid-Infrared Refractive Indices of GaAs/AlGaAs

We present our results for a simultaneous measurement of the refractive indices of Gallium Arsenide (GaAs) and Aluminum Gallium Arsenide (Al$_\mathrm{x}$Ga$_\mathrm{1-x}$As) in the spectral region from $2.0$ to $7.1\,\mathrm{\mu}\mathrm{m}$ ($5000$ to $1400\,\mathrm{cm^{-1}}$). These values are obtained from a monocrystalline thin-film multilayer Bragg mirror of excellent purity (background doping $\leq 1 \times 10^{-14}\,\mathrm{cm^{-3}}$), grown via molecular beam epitaxy. To recover the refractive indices over such a broad wavelength range, we fit a dispersion model for each material. For that, we measure both a photometrically accurate transmittance spectrum of the Bragg mirror via Fourier-transform infrared spectrometry and the individual physical layer thicknesses of the structure via scanning electron microscopy. To infer the uncertainty of the refractive index values, we estimate relevant measurement uncertainties and propagate them via a Monte-Carlo-type method. This method conclusively yields propagated relative uncertainties on the order of $10^{-4}$ over the measured spectral range for both GaAs and Al$_{0.929}$Ga$_{0.071}$As. The fitted model can also approximate the refractive index for MBE-grown Al$_\mathrm{x}$Ga$_\mathrm{1-x}$As for $0 \leq x \leq 1$. These updated values will be essential in the design and fabrication of next-generation active and passive optical devices in a spectral region which is of high interest in many fields, e.g., laser design and cavity-enhanced spectroscopy.Comment: 20 pages, 5 figures, submitted to PR

Multiproject–multicenter evaluation of automatic brain tumor classification by magnetic resonance spectroscopy

Contains fulltext : 75361.pdf (publisher's version ) (Open Access)14 p

Versatile Figure-9 Design: How to Access Low-Noise Regimes in an All-PM Yb:Fiber Lasern

We present a versatile all-PM Yb:fiber-laser and demonstrate the impact of dispersion engineering on amplitude/phase noise and the carrier-envelope-offset frequency, whose linewidth can be reduced from several MHz down to single-digit-kHz values in free-running operation

Flexible all-PM NALM Yb:fiber laser design for frequency comb applications: operation regimes and their noise properties

We present a flexible all-polarization-maintaining (PM) mode-locked ytterbium (Yb):fiber laser based on a nonlinear amplifying loop mirror (NALM). In addition to providing detailed design considerations, we discuss the different operation regimes accessible by this versatile laser architecture and experimentally analyze five representative mode-locking states. These five states were obtained in a 78-MHz configuration at different intracavity group delay dispersion (GDD) values ranging from anomalous (-0.035 ps$^2$) to normal (+0.015 ps$^2$). We put a particular focus on the characterization of the intensity noise as well as the free-running linewidth of the carrier-envelope-offset (CEO) frequency as a function of the different operation regimes. We observe that operation points far from the spontaneous emission peak of Yb (~1030 nm) and close to zero intracavity dispersion can be found, where the influence of pump noise is strongly suppressed. For such an operation point, we show that a CEO linewidth of less than 10-kHz at 1 s integration can be obtained without any active stabilization

Spectrally tunable high-power Yb:fiber chirped-pulse amplifier

Tailoring the properties of the driving laser to the need of applications often requires compromises among laser stability, high peak and average power levels, pulse duration, and spectral bandwidth. For instance, spectroscopy with optical frequency combs in the extreme/visible ultraviolet spectral region requires a high peak power of the near-IR driving laser, and therefore high average power, pulse duration of a few tens of fs, and maximal available spectral bandwidth. Contrarily, the parametric conversion efficiency is higher for pulses with a duration in the 100-fs range due to temporal walk-off and coating limitations. Here we suggest an approach to adjust the spectral characteristics of high-power chirped-pulse amplification (CPA) to the requirements of different nonlinear frequency converters while preserving the low-phase-noise (PN) properties of the system. To achieve spectral tunability, we installed a mechanical spectral shaper in a free-space section of the stretcher of an in-house-developed ytterbium-fiber-based CPA system. The CPA system delivers 100 W of average power at a repetition rate of 132.4 MHz. While gaining control over the spectral properties, we preserve the relative-intensity-noise and PN properties of the system. The high-power CPA can easily be adjusted to deliver either a spectrum ideal for mid-IR light generation (full width at half maximum of ∼11 nm, compressed pulse duration of 230 fs) or a spectrum ideal for highly nonlinear processes such as high-harmonic generation (−10 dB level of >50 nm, transform-limited pulse duration of ∼65 fs)

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis. We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4 ± 1 protein-changing mutations per million base pairs. Therefore, we conducted integrated analyses of the various data sets to identify pathogenetically relevant mutated genes. In all cases, we found evidence for inactivation of TP53 and RB1 and identified recurrent mutations in the CREBBP, EP300 and MLL genes that encode histone modifiers. Furthermore, we observed mutations in PTEN, SLIT2 and EPHA7, as well as focal amplifications of the FGFR1 tyrosine kinase gene. Finally, we detected many of the alterations found in humans in SCLC tumors from Tp53 and Rb1 double knockout mice. Our study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background