Can the Holmes-Rahe Social Readjustment Rating Scale (SRRS) Be Used as a Suicide Risk Scale? An Exploratory Study

The objective of this research was to examine whether the Holmes-Rahe Social Readjustment Rating Scale, a life event scale, can be used to identify suicide attempters. The Holmes-Rahe Social Readjustment Rating Scale\u27s ability to identify suicide attempters was tested in 1183 subjects (478 suicide attempters, 197 psychiatric inpatients, and 508 healthy controls) using the Fisher Linear Discriminant Analysis and traditional psychometric methods. The Fisher Linear Discriminant Analysis outperformed traditional psychometric approaches (area under the curve: 0.85 vs. 0.78; p \u3c 0.05) and indicated that this scale may be used to identify suicide attempters. The life events that better characterized suicide attempters were change in frequency of arguments, marital separation, and personal injury. The Holmes-Rahe Social Readjustment Rating Scale may help identify suicide attempters

Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth

BACKGROUND: Melanoma is the most deadly form of skin cancer without effective treatment. Methylthioadenosine (MTA) is a naturally occurring nucleoside with differential effects on normal and transformed cells. MTA has been widely demonstrated to promote anti-proliferative and pro-apoptotic responses in different cell types. In this study we have assessed the therapeutic potential of MTA in melanoma treatment. METHODS: To investigate the therapeutic potential of MTA we performed in vitro proliferation and viability assays using six different mouse and human melanoma cell lines wild type for RAS and BRAF or harboring different mutations in RAS pathway. We also have tested its therapeutic capabilities in vivo in a xenograft mouse melanoma model and using variety of molecular techniques and tissue culture we investigated its anti-proliferative and pro-apoptotic properties. RESULTS: In vitro experiments showed that MTA treatment inhibited melanoma cell proliferation and viability in a dose dependent manner, where BRAF mutant melanoma cell lines appear to be more sensitive. Importantly, MTA was effective inhibiting in vivo tumor growth. The molecular analysis of tumor samples and in vitro experiments indicated that MTA induces cytostatic rather than pro-apoptotic effects inhibiting the phosphorylation of Akt and S6 ribosomal protein and inducing the down-regulation of cyclin D1. CONCLUSIONS: MTA inhibits melanoma cell proliferation and in vivo tumor growth particularly in BRAF mutant melanoma cells. These data reveal a naturally occurring drug potentially useful for melanoma treatment

La utilización de la metodología ApS refuerza la adquisición de competencias a largo plazo

[EN] Service-learning (SL) is a methodology that contributes to the formation of values and the citizenship of university students, who can acquire a relevant role in the construction of a more dignified, inclusive, cohesive and equitable citizenship. The objective of the work is to quantify how the SL methodology implemented in a subject improves the competences of the students in the same course of implementation and after one year of implementation. Four experimental groups were formed: a) group LS-course 2017-2018; b) group NO-LS-course 2017-2018; c) group LS-course 2018-2019; d) group NO-LScourse 2018-2019. Each one of the groups was evaluated during the academic year 2018-2019 in the competencies developed in the subject Clinical Neurology applied to the speech therapist where the LS project is implemented. The results were compared by means of a t-Student. The results showed that the LS-course 2018-2019 group of students obtained significantly higher grades than the NO-LS-course 2018-2019 group. Surprisingly, this result was maintained during the academic year 2018-2019, in the students where the LS project had been implemented in the academic year 2017-2018, so that the LScourse 2017-2018 group continued to maintain higher and significantly higher grades than the NO-LS- course 2017-2018.[ES] El aprendizaje-servicio (ApS) es una metodología que contribuye a la formación en valores y para la ciudadanía de los estudiantes universitarios, los cuales pueden adquirir un papel relevante en la construcción de una ciudadanía más digna, inclusiva, cohesionada y equitativa. El objetivo del trabajo es cuantificar cómo la metodología ApS instaurada en una asignatura mejora las competencias del alumnado en el mismo curso de implantación y pasado un año de la implantación. Para ello se han formaron cuatro grupos experimentales: a) grupo ApS-curso 2017-2018; b) grupo NO-ApS-curso 2017-2018; c) grupo APS-curso 2018-2019; d) grupo NO-ApS-curso 2018-2019. Cada uno de los grupos fue evaluado durante el curso 2018-2019 en las competencias desarrolladas en la asignatura Neurología clínica aplicada a la logopeda donde se implanta el proyecto ApS. Los resultados se compararon mediante un t-Test. Los resultados mostraron que el grupo de alumnos ApS-curso 2018-2019 obtuvieron notas significativamente superiores al grupo NO-ApS curso 2018-2019. Sorprendentemente, este resultado se mantenía durante el curso 2018-2019, en los alumnos donde se había implantado el proyecto ApS en el curso 2017-2018, de forma que el grupo ApS curso 2017-2018 seguía manteniendo notas superiores y significativamente superiores respecto al grupo NO-ApS-curso 2017-2018.Innovation Project Universitat de Valencia nº UV-SFPIE_RMD18-841128.Perez Gil, T.; Martinez Gisbert, N.; Soler Molina, V.; Puchades Diaz, S.; Gimenez Martínez, E.; Hurtado Vizcaino, C.; Ortiz Masià, D. (2019). La utilización de la metodología ApS refuerza la adquisición de competencias a largo plazo. En IN-RED 2019. V Congreso de Innovación Educativa y Docencia en Red. Editorial Universitat Politècnica de València. 343-352. https://doi.org/10.4995/INRED2019.2019.10417OCS34335

La metodología ApS refuerza la adquisición de competencias generales y específicas

[EN] Service-learning (SL), through a process of action-reflection-action collaborates in an efficient and practical way to the consolidation of basic and specific competencies that contribute to a successful life and good social functioning. The aim of the work is to analyse how the SL methodology improves general and specific competences in the students. To this end, two experimental groups were formed: a) SL group; b) NO-SL group (control). Each of the groups was evaluated in specific competences (exploration of cranial pairs) and general competences (communication, adaptation,..). The results were compared using the t-Student test. The results showed that the SL group significantly improved, in a majority way, the competences evaluated in relation with the control group.[ES] El Aprendizaje-Servicio (ApS), mediante un proceso de acción-reflexión-acción colabora de manera eficiente y práctica a la consolidación de competencias básicas y específicas que contribuyen a una vida exitosa y al buen funcionamiento social. El objetivo del trabajo es analizar cómo la metodología ApS mejora competencias generales y específicas en el alumnado. Para ello se han formaron dos grupos experimentales: a) grupo ApS; b) grupo NO-ApS (control). Cada uno de los grupos fue evaluado en competencias específicas (exploración de pares craneales) y generales (comunicación, adaptación, etc.). Los resultados se compararon mediante el test t-Student. Los resultados mostraron que el grupo ApS mejoraban significativamente, de forma mayoritaria, las competencias evaluadas respecto al grupo control.Innovation Project Universitat de Valencia nº UV-SFPIE_RMD18-841128.Perez Gil, T.; Martínez Gisbert, N.; Soler Molina, V.; Puchades Díaz, S.; Giménez Martínez, E.; Hurtado Vizcaíno, C.; Ortiz-Masià, D. (2019). La metodología ApS refuerza la adquisición de competencias generales y específicas. En IN-RED 2019. V Congreso de Innovación Educativa y Docencia en Red. Editorial Universitat Politècnica de València. 1529-1536. https://doi.org/10.4995/INRED2019.2019.10376OCS1529153

Breast cancer patient’s outcomes after neoadjuvant chemotherapy and surgery at 5 and 10 years for stage II–III disease

Introduction: Neoadjuvant chemotherapy in breast cancer offers the possibility to facilitate breast and axillary surgery; it is a test of chemosensibility in vivo with significant prognostic value and may be used to tailor adjuvant treatment according to the response. Material and Methods: A retrospective single-institution cohort of 482 stage II and III breast cancer patients treated with neoadjuvant chemotherapy based on anthracycline and taxans, plus antiHEr2 in Her2-positive cases, was studied. Survival was calculated at 5 and 10 years. Kaplan-Meier curves with a log-rank test were calculated for differences according to age, BRCA status, menopausal status, TNM, pathological and molecular surrogate subtype, 20% TIL cut-off, surgical procedure, response to chemotherapy and the presence of vascular invasion. Results: The pCR rate was 25.3% and was greater in HER2 (51.3%) and TNBC (31.7%) and in BRCA carriers (41.9%). The factors independently related to patient survival were pathology and molecular surrogate subtype, type of surgery, response to NACT and vascular invasion. BRCA status was a protective prognostic factor without reaching statistical significance, with an HR 0.5 (95%CI 0.1-1.4). Mastectomy presented a double risk of distant recurrence compared to breast-conservative surgery (BCS), supporting BCS as a safe option after NACT. After a mean follow-up of 126 (SD 43) months, luminal tumors presented a substantial difference in survival rates calculated at 5 or 10 years (81.2% compared to 74.7%), whereas that for TNBC was 75.3 and 73.5, respectively. The greatest difference was seen according to the response in patients with pCR, who exhibited a 10 years DDFS of 95.5% vs. 72.4% for those patients without pCR, p < 0001. This difference was especially meaningful in TNBC: the 10 years DDFS according to an RCB of 0 to 3 was 100%, 80.6%, 69% and 49.2%, respectively, p < 0001. Patients with a particularly poor prognosis were those with lobular carcinomas, with a 10 years DDFS of 42.9% vs. 79.7% for ductal carcinomas, p = 0.001, and patients with vascular invasion at the surgical specimen, with a 10 years DDFS of 59.2% vs. 83.6% for those patients without vascular invasion, p < 0.001. Remarkably, BRCA carriers presented a longer survival, with an estimated 10 years DDFS of 89.6% vs. 77.2% for non-carriers, p = 0.054. Conclusions: Long-term outcomes after neoadjuvant chemotherapy can help patients and clinicians make well-informed decisions

Laparoscopic surgery in 3D improves results and surgeon convenience in sleeve gastrectomy for morbid obesity

Purpose Advanced laparoscopic procedures are still challenging. One critical issue is the lack of stereoscopic vision. The aim of this surgical study is to evaluate whether 3D vision offers any advantages for surgical performance over 2D vision during sleeve gastrectomy for morbid obesity using a laparoscopic system that allows changing between 2D and 3D optics. Methods A total of 78 patients were analyzed, with 37 in the 2D group and 41 in the 3D group. Performance time, hospital stay, complications, and early outcomes were collected. To assess the quality of the 2D and 3D techniques, visual analog scales from 0 to 10 were designed, and image quality, depth of field, precision in performing tasks, and general ergonomics were measured. Results According to the vision system used, the mean duration of surgery was 85 ± 16.8 min for patients operated on with the 2D system and 69 ± 16.9 min for those operated on with the 3D system. There were no significant differences between the overall percentages of complications according to the type of vision used. However, postoperative complications were more severe in the 2D laparoscopy group. The average length of stay was shorter for patients in the 3D group. Regarding the differences perceived by the surgeon, the depth of field and the precision of tasks were better in the 3D vision group. Conclusion The 3D system provided greater depth perception and precision in more complex tasks, enabling safer surgery. This led to a reduction in the operative time and hospital stay. Moreover, the severity of complications was less

Follow-up of gone away in the accreditation of Master in Infirmary of the BUAP

[EN] Introduction: The follow-up of gone away is an indicator of the relevancy of the Study plan, in case of the Master in Infirmary it is a source of information for the modification of the programs of the subjects as well as the identification of the needs of education continues of the gone away ones. Aims To identify the opinion of the gone away ones from the study plan, that course, requirements of the labor market, professional performance and needs of update. Methodology: Type of study: descriptive, longitudinal. Results: They met 1120egresados, 65 % of the gone away ones obtained employment to six months of concluding the career, the principal activity that they realize is the care of patients, 59 % thinks that the labor coincidence is total with his studies, the economic sector at which they are employed is that of services of health. He thinks that the content of the programs of the subjects as well as the knowledge of the teachers as good, 86. % would return to study the master in infirmary. Conclusion: the opinion of the gone away ones has allowed the extension of the practices, the implementation of the programs of the specialities of infirmary and that the program of the master continues being an educational program of quality when assessors are accredited by the organisms as COMACE CIEES[ES] Introducción: El seguimiento de egresados es un indicador de la pertinencia del Plan de Estudios, en el caso de la Licenciatura en Enfermería es fuente de información para la modificación de los programas de las asignaturas así como la identificación de las necesidades de educación continua de los egresados.Objetivos: Identificar la opinión de los egresados del plan de estudios, que curso, exigencias del mercado laboral, desempeño profesional y necesidades de actualización.Metodología: Tipos de estudio: descriptivo, longitudinal.Resultados: Se entrevistaron 1120egresados, el 65% de los egresados obtuvieron empleo a los seis meses de concluir la carrera, la principal actividad que realizan es el cuidado de pacientes, el 59% opina que es total la coincidencia laboral con sus estudios, el sector económico en el que trabajan es el de servicios de salud. Opina que el contenido de los programas de las asignaturas así como los conocimientos de los docentes como buenos, el 86 % volvería estudiar la licenciatura en enfermería.Conclusión: la opinión de los egresados ha permitido la ampliación de las practicas, la implementación de los programas de las especialidades de enfermería y que el programa de la licenciatura siga siendo un programa educativo de calidad al ser acreditado por los organismos evaluadores como COMACE CIFRUS.Salazar Peña, MTL.; Trujillo De La Cruz, C.; Perez Noriega, E.; Bonilla Luis, MDLL.; Rios Palacios, N.; Morales Espinoza, MDL.; Huesca Gil, JLA. (2014). Seguimiento de egresados en la acreditación de Licenciatura en Enfermeria de la BUAP. En CONFERENCIA INTERNACIONAL INFOACES. UN SISTEMA DE INFORMACIÓN PARA LAS UNIVERSIDADES LATINOAMERICANAS. LIBRO DE ACTAS. Editorial Universitat Politècnica de València. 83-86. http://hdl.handle.net/10251/85894OCS838

Adjuvant dabrafenib and trametinib for patients with resected BRAF-mutated melanoma: DESCRIBE-AD real-world retrospective observational study

BRAF and MEK inhibitor, dabrafenib plus trametinib, adjuvant therapy is effective for high-risk resected melanoma patients with BRAF-V600 mutations. However, real-world evidence is limited. We aimed to determine the feasibility of this therapy in routine clinical practice. DESCRIBE-AD, a retrospective observational study, collected real-world data from 25 hospitals in Spain. Histologically confirmed and resected BRAF-mutated melanoma patients aged & GE;18 years who were previously treated with dabrafenib plus trametinib adjuvant therapy, were included. The primary objectives were treatment discontinuation rate and time to discontinuation. The secondary objectives included safety and efficacy. From October 2020 to March 2021, 65 patients were included. Dabrafenib and trametinib discontinuation rate due to treatment-related adverse events (TRAEs) of any grade was 9%. Other reasons for discontinuation included patients' decisions (6%), physician decisions (6%), unrelated adverse events (3%), disease progression (5%), and others (5%). The median time to treatment discontinuation was 9 months [95% confidence interval (CI), 5-11]. G3-4 TRAEs occurred in 21.5% of patients, the most common being pyrexia (3%), asthenia (3%), and diarrhoea (3%). Unscheduled hospitalisations and clinical tests occurred in 6 and 22% of patients, respectively. After 20-month median follow-up (95% CI, 18-22), 9% of patients had exitus due to disease progression, with a 12-month relapse-free survival and overall survival rates of 95.3% and 100%, respectively. Dabrafenib and trametinib adjuvant therapy proved effective for melanoma patients in a real-world setting, with a manageable toxicity profile. Toxicity frequencies were low leading to low incidence of unscheduled medical visits, tests, and treatment discontinuations