The challenges of urban ageing:Making cities age-friendly in Europe

Urban ageing is an emerging domain that deals with the population of older people living in cities. The ageing of society is a positive yet challenging phenomenon, as population ageing and urbanisation are the culmination of successful human development. One could argue whether the city environment is an ideal place for people to grow old and live at an old age compared to rural areas. This viewpoint article explores and describes the challenges that are encountered when making cities age-friendly in Europe. Such challenges include the creation of inclusive neighbourhoods and the implementation of technology for ageing-in-place. Examples from projects in two age-friendly cities in The Netherlands (The Hague) and Poland (Cracow) are shown to illustrate the potential of making cities more tuned to the needs of older people and identify important challenges for the next couple of years. Overall, the global ageing of urban populations calls for more age-friendly approaches to be implemented in our cities. It is a challenge to prepare for these developments in such a way that both current and future generations of older people can benefit from age-friendly strategies

3-D Photoionization Structure and Distances of Planetary Nebulae II. Menzel 1

We present the results of a spatio-kinematic study of the planetary nebula Menzel 1 using spectro-photometric mapping and a 3-D photoionization code. We create several 2-D emission line images from our long-slit spectra, and use these to derive the line fluxes for 15 lines, the Halpha/Hbeta extinction map, and the [SII] line ratio density map of the nebula. We use our photoionization code constrained by these data to derive the three-dimensional nebular structure and ionizing star parameters of Menzel 1 by simultaneously fitting the integrated line intensities, the density map, and the observed morphologies in several lines, as well as the velocity structure. Using theoretical evolutionary tracks of intermediate and low mass stars, we derive a mass for the central star of 0.63+-0.05 Msolar. We also derive a distance of 1050+_150 pc to Menzel 1.Comment: To be published in ApJ of 10th February 2005. 12 figure

Tomographic reconstruction of the runaway distribution function in TCV using multispectral synchrotron images

Synchrotron radiation observed in a quiescent Tokamak Configuration Variable (TCV) runaway discharge is studied using filtered camera images targeting three distinct wavelength intervals. Through the tomographic simultaneous algebraic reconstruction technique (SART) procedure the high momentum, high pitch angle part of the spatial and momentum distribution of these relativistic particles is reconstructed. Experimental estimates of the distribution are important for verification and refinement of formation-, decay- and transport-models underlying runaway avoidance and mitigation strategy design. Using a test distribution it is demonstrated that the inversion procedure provides estimates accurate to within a few tens of percent in the region of phase-space contributing most to the synchrotron image. We find that combining images filtered around different parts of the emission spectrum widens the probed part of momentum-space and reduces reconstruction errors. Next, the SART algorithm is used to obtain information on the spatiotemporal runaway momentum distribution in a selected TCV discharge. The momentum distribution is found to relax towards an avalanche-like exponentially decaying profile. Anomalously high pitch angles and a radial profile increasing towards the edge are found for the most strongly emitting particles in the distribution.Pitch angle scattering by toroidal magnetic field ripple is consistent with this picture. An alternative explanation is the presence of high frequency instabilities in combination with the formation of a runaway shell at the edge of the plasma. </p

Demonstration of a sparse sensor placement technique to the limited diagnostic set in a fusion power plant

DEMO will have a limited diagnostic set for optimization of reactor performance, and limited diagnostic coverage due to challenging reactor conditions. This poses challenges for control, especially for detachment control which is planned to be performed with a limited set of spectroscopic lines-of-sight. To demonstrate mitigation of the coverage problem, we have implemented a sparse sensor placement technique on TCV for the case of spectroscopy. Experimental CIII 2D emissivity profiles from the MANTIS multispectral imaging system at TCV are used to create a synthetic spectroscopy system, with DEMO-relevant lines-of-sight. This synthetic diagnostic is validated through comparison with spectroscopic measurements in TCV. The sparse sensor placement algorithm takes as input the radiance calculated for a large set of lines-of-sight, resolved in time. It provides a method to reconstruct an emission profile along the divertor leg based on measurements from only a few lines-of-sight. We demonstrate that it is feasible to use a calibration based on either experimental data or simulated emissivities from SOLPS-ITER. As a result, for DEMO, the line-of-sight selection and a mathematical basis for reconstruction can be obtained before the reactor is turned on. The sparse sensor placement method can also be applied to estimate other physical quantities from emission measurements, if they have a one-to-one relationship with the shape of the emission profile along the divertor leg. As an example, the peak target current density obtained with Langmuir probes can be reconstructed using spectroscopy measurements. Lastly, the geometry of the lines-of-sight plays an important role in proper emission profile reconstruction. It should be tailor-made to the used magnetic configuration to measure the emission profile accurately, and the technique described here offers a route for performing this optimization.</p

Runaway electron synchrotron radiation in a vertically translated plasma

Synchrotron radiation observed from runaway electrons (REs) in tokamaks depends upon the position and size of the RE beam, the RE energy and pitch distributions, as well as the location of the observer. We show that experimental synchrotron images of a vertically moving runaway electron beam sweeping past the detector in the TCV tokamak agree well with predictions from the synthetic synchrotron diagnostic Soft. This experimental validation lends confidence to the theory underlying the synthetic diagnostics which are used for benchmarking theoretical models of and probing runaway dynamics. We present a comparison of synchrotron measurements in TCV with predictions of kinetic theory for runaway dynamics in uniform magnetic fields. We find that to explain the detected synchrotron emission, significant non-collisional pitch angle scattering as well as radial transport of REs would be needed. Such effects could be caused by the presence of magnetic perturbations, which should be further investigated in future TCV experiments.Comment: 7 pages, 4 figures. Accepted for publication in Nuclear Fusio

Development of a real-time algorithm for detection of the divertor detachment radiation front using multi-spectral imaging

In this paper we present a novel algorithm to extract the optical plasma boundary and radiation front for detached divertor plasmas. We show that reliable detection of the divertor leg and radiation front is possible using lightweight image processing tools. Using a non-tomographic approach, the detected divertor leg and radiation front can be mapped to the poloidal plane. This approach is fast and accurate enough for real-time control purposes, allowing in particular real-time plasma shape and detachment control, and post-shot detachment physics and dynamics analysis.</p

Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study

BackgroundThis multicenter phase II study investigated temozolomide + irinotecan (TEMIRI) treatment in children with relapsed or refractory medulloblastoma.MethodsPatients received temozolomide 100–125 mg/m2/day (days 1–5) and irinotecan 10 mg/m2/day (days 1–5 and 8–12) every 3 weeks. The primary endpoint was tumor response within the first 4 cycles confirmed ≥4 weeks and assessed by an external response review committee (ERRC). In a 2-stage Optimum Simon design, ≥6 responses in the first 15 evaluable patients were required within the first 4 cycles for continued enrollment; a total of 19 responses from the first 46 evaluable patients was considered successful.ResultsSixty-six patients were treated. Seven responses were recorded during stage 1 and 15 in the first 46 ERRC evaluated patients (2 complete responses and 13 partial responses). The objective response rate during the first 4 cycles was 32.6% (95% confidence interval [CI], 19.5%–48.0%). Median duration of response was 27.0 weeks (7.7–44.1 wk). In 63 patients evaluated by local investigators, the objective response rate was 33.3% (95% CI, 22.0%–46.3%), and 68.3% (95% CI, 55.3%–79.4%) experienced clinical benefit. Median survival was 16.7 months (95% CI, 13.3–19.8). The most common grade 3 treatment-related nonhematologic adverse event was diarrhea (7.6%). Grade 3/4 treatment-related hematologic adverse events included neutropenia (16.7%), thrombocytopenia (12.1%), anemia (9.1%), and lymphopenia (9%).ConclusionsThe planned study primary endpoint was not met. However, its tolerability makes TEMIRI a suitable candidate chemotherapy backbone for molecularly targeted agents in future trials in this setting

Pelvic actinomycosis presenting as a malignant pelvic mass: a case report

<p>Abstract</p> <p>Introduction</p> <p>Pelvic actinomycosis constitutes 3% of all human actinomycosis infections. It is usually insidious, and is often mistaken for other conditions such as diverticulitis, abscesses, inflammatory bowel disease and malignant tumors, presenting a diagnostic challenge pre-operatively; it is identified post-operatively in most cases. Here we present a case that presented as pelvic malignancy and was diagnosed as pelvic actinomycosis post-operatively.</p> <p>Case presentation</p> <p>A 48-year-old Caucasian Turkish woman presented to our clinic with a three-month history of abdominal pain, weight loss and difficulty in defecation. She had used an intra-uterine device for 16 years, however it had recently been removed. The rectosigmoidoscopy revealed narrowing of the lumen at 12 cm due to a mass lesion either in the wall or due to an extrinsic lesion that prevented the passage of the endoscope. On examination, there was no gynecological pathology. Magnetic resonance imaging showed a mass, measuring 5.5 × 4 cm attached to the rectum posterior to the uterus. The ureter on that side was dilated. Surgically there was a pelvic mass adhered to the rectum and uterine adnexes, measuring 10 × 12 cm. It originated from uterine adnexes, particularly ones from the left side and formed a conglomerated mass with the uterus and nearby organs; the left ureter was also dilated due to the pelvic mass. Because of concomitant tubal abscess formation and difficulty in dissection planes, total abdominal hysterectomy and bilateral salphingo-oophorectomy was performed (our patient was 48 years old and had completed her childbearing period). The cytology revealed inflammatory cells with aggregates of <it>Actinomyces</it>. Penicillin therapy was given for six months without any complication.</p> <p>Conclusions</p> <p>Pelvic actinomycosis should always be considered in patients with a pelvic mass especially in ones using intra-uterine devices, and who have a history of appendectomy, tonsillectomy or dental infection. Surgeons should be aware of this infection in order to avoid excessive surgical procedures.</p