119 research outputs found
Association Of Lipophilic Opioids And Hyperbaric Bupivacaine In Spinal Anesthesia For Elective Cesarean Section. Randomized Controlled Study
PURPOSE: To evaluate the efficacy and side-effects of fentanyl and sufentanil combined with hyperbaric spinal bupivacaine in elective cesarean section.METHODS: A prospective, randomized, double-blind study with 64 term parturients, distributed into 2 groups according to the opioid combined with hyperbaric bupivacaine 0.5% (10mg): GF - fentanyl (25μg) and GS - sufentanil (5.0μg). The latency and maximum sensory block level; degree and duration of motor block; duration and quality of analgesia; maternal-fetal repercussions were evaluated. This was an intention-to-treat analysis with a 5% significance level.RESULTS: The latency period, maximum sensory block level, motor block degree and perioperative analgesia were similar in both groups. Motor block and analgesia had a longer duration in the sufentanil group. Maternal adverse effects and neonatal repercussions were similar. The incidence of hypotension was higher in the fentanyl group. In both groups, there was a predominance of patients who were awake and either calm or sleepy.CONCLUSIONS: The addition of fentanyl and sufentanil to hyperbaric subarachnoid bupivacaine was shown to be effective for the performance of cesarean section, and safe for the mother and fetus. Analgesia was more prolonged with sufentanil.2911752758Dahlgren, G., Hultstrand, C., Jakobsson, J., Norman, M., Eriksson, E.W., Martin, H., Intrathecal sufentanil, fentanyl, or placebo added to bupivacaine for cesarean section (1997) Anesth Analg, 85 (6), pp. 1288-1293. , Dec, PMID: 9390596Dyer, R.A., Joubert, I.A., Low-dose spinal anaesthesia for Caesarean section (2004) Curr Opin Anaesthesiol, 17 (4), pp. 301-308. , 2004 Aug, PMID: 17021569Arzola, C., Wieczorek, P.M., Efficacy of low-dose bupivacaine in spinal anaesthesia for Caesarean delivery: Systematic review and meta-analysis (2011) Br J Anaesth, 107 (3), pp. 308-318. , Sep, Epub 2011 Jul 14Braga Ade, F., Frias, J.A., Braga, F.S., Pereira, R.I., Titotto, S.M., Spinal anesthesia for elective ceasarean section: Use of different doses of hyperbaric bupivacaine associated with morphine and clonidine (2013) Acta Cir Bras, 28 (1), pp. 26-32. , Jan, PMID: 23338110Braga Ade, F., Braga, F.S., Potério, G.M., Pereira, R.I., Reis, E., Cremonesi, E., Sufentanil added to hyperbaric bupivacaine for subarachnoid block in Caesarean section (2003) Eur J Anaesthesiol, 20 (8), pp. 631-635. , Aug, PMID: 12932064Braga Ade, F., Frias, J.A., Braga, F.S., Pinto, D.R., Spinal block with 10 mg of hyperbaric bupivacaine associated with 5 microg of sufentanil for cesarean section. Study of different volumes (2010) Rev Bras Anestesiol, 60 (2), pp. 121-129. , Mar-Apr, PMID: 20485956Karaman, S., Kocabas, S., Uyar, M., Hayzaran, S., Firat, V., The effects of sufentanil or morphine added to hyperbaric bupivacaine in spinal anaesthesia for caesarean section (2006) Eur J Anaesthesiol, 23 (4), pp. 285-291. , Apr, PMID: 16438758Braga, A.A., Frias, J.A., Braga, F.S., Potério, G.B., Hirata, E.S., Torres, N.A., Spinal anesthesia for cesarean section. Use of hyperbaric bupivacaine (10mg) combined with different adjuvants (2012) Rev Bras Anestesiol, 62 (6), pp. 775-787. , Nov-Dec, PMID: 23176986Karaman, S., Günüsen, I., Uyar, M., Biricik, E., Fırat, V., The effects of morphine and fentanyl alone or in combination added to intrathecal bupivacaine in spinal anesthesia for cesarean section (2011) Agri, 23 (2), pp. 57-63. , Apr, PMID: 21644105Filos, K.S., Goudas, L.C., Patroni, O., Polyzou, V., Intrathecal clonidine as a sole analgesic for pain relief after cesarean section (1992) Anesthesiology, 77 (2), pp. 267-274. , Aug, PMID: 1642346Braz, J.R., Koguti, E.S., Braz, L.G., Croitor, L.B., Navarro, L.H., Effects of clonidine associated to hyperbaric bupivacaine during high-level spinal anesthesia (2003) Rev Bras Anestesiol, 53 (5), pp. 561-572. , Sep, PMID: 19475309Hamber, E.A., Viscomi, C.M., Intrathecal lipophilic opioids as adjuncts to surgical spinal anesthesia (1999) Reg Anesth Pain Med, 24, pp. 255-263. , May- Jun, PMID: 10338179Abouleish, E., Rawal, N., Fallon, K., Hernandez, D., Combined intrathecal morphine and bupivacaine for cesarean section (1988) Anesth Analg, 67 (4), pp. 370-374. , Apr, PMID: 3354872Abouleish, E., Apnoea associated with the intrathecal administration of morphine in obstetrics. A case report (1988) Br J Anaesth, 60 (5), pp. 592-594. , Apr, PMID: 3377935Chu, C.C., Shu, S.S., Lin, S.M., Chu, N.W., Leu, Y.K., Tsai, S.K., Lee, T.Y., The effect of intrathecal bupivacaine with combined fentanyl in cesarean section (1995) Acta Anaesthesiol Sin, 33 (3), pp. 149-154. , Sep, PMID: 7493145Belzarena, S.D., Clinical effects of intrathecally administered fentanyl in patients undergoing cesarean section (1992) Anaesth Analg, 74 (5), pp. 653-657. , May, PMID: 1567031Idowu, O.A., Sanusi, A.A., Eyelade, O.R., Effects of intrathecally administered fentanyl on duration of analgesia in patients undergoing spinal anaesthesia for elective caesarean section (2011) Afr J Med Med Sci, 40 (3), pp. 213-219. , Sep, PMID: 22428515Hunt, C.O., Naulty, J.S., Bader, A.M., Hauch, M.A., Vartikar, J.V., Datta, S., Hertwig, L.M., Ostheimer, G.W., Perioperative analgesia with subarachnoid fentanyl-bupivacaine for cesarean delivery (1989) Anesthesiology, 71 (4), pp. 535-540. , Oct, PMID: 2679237Sibilla, C., Albertazz, P., Zatelli, R., Martinello, R., Perioperative analgesia for caesarean section: Comparison of intrathecal morphine and fentanyl alone or in combination (1997) Int J Obstet Anesth, 6 (1), pp. 43-48. , Jan, PMID: 15321310Courtney, M.A., Bader, A.M., Hartwell, B., Hauch, M., Grennan, M.J., Datta, S., Perioperative analgesia with subarachnoid sufentanil administration (1992) Reg Anesth, 17 (5), pp. 274-278. , Sep-Oct, PMID: 1419940Akkamahadevi, P., Srinivas, H., Siddesh, A., Kadli, N., Comparision of efficacy of sufentanil and fentanyl with low-concentration bupivacaine for combined spinal epidural labour analgesia (2012) Indian J Anaesth, 56 (4), pp. 365-369. , JulLee, J.H., Chung, K.H., Lee, J.Y., Chun, D.H., Yang, H.J., Ko, T.K., Yun, W.S., Comparison of fentanyl and sufentanil added to 0.5% hyperbaric bupivacaine for spinal anesthesia in patients undergoing cesarean section (2011) Korean J Anesthesiol, 60 (2), pp. 103-108. , FebBang, Y.S., Chung, K.H., Lee, J.H., Hong, S.K., Choi, S.H., Lee, J.Y., Lee, S.Y., Yang, H.J., Comparison of clinical effects according to the dosage of sufentanil added to 0.5% hyperbaric bupivacaine for spinal anesthesia in patients undergoing cesarean section (2012) Korean J Anesthesiol, 63 (4), pp. 321-326. , OctNelson, K.E., Rauch, T., Terebuh, V., D’angelo, R., A comparison of intrathecal fentanyl and sufentanil for labor analgesia (2002) Anesthesiology, 96 (5), pp. 1070-1073. , May, PMID: 11981144Grass, J.A., Sakima, N.T., Schmidt, R., Michitsch, R., Zuckerman, R.L., Harris, A.P., A randomized, double-blind, dose-response comparison of epidural fentanyl versus sufentanil analgesia after cesarean section (1997) Anesth Analg, 85 (2), pp. 365-371. , Aug, PMID: 9249115Vyas, N., Sahu, D.K., Parampill, R., Comparative study of intrathecal sufentanil bupivacaine versus intrathecal bupivacaine in patients undergoing elective cesarean section (2010) J Anaesthesiol Clin Pharmacol, 26 (4), pp. 488-492. , Oct, PMID: 21547176Trivedi, V., Jha, A., A comparative clinical study of intrathecal fentanyl v/s sufentanil with bupivacaine for postoperative analgesia in emergency or elective cesarean section (2008) Indian J Pain, 22, pp. 157-162Dahl, J.B., Jeppesen, I.S., Jørgensen, H., Wetterslev, J., Møiniche, S., Intraoperative and postoperative analgesic efficacy and adverse effects of intrathecal opioids in patients undergoing cesarean section with spinal anesthesia: A qualitative and quantitative systematic review of randomized controlled trials (1999) Anesthesiology, 91 (6), pp. 1919-1927. , Dec, PMID: 10598635Kjellberg, F., Tramèr, M.R., Pharmacological control of opioid-induced pruritus: A quantitative systematic review of randomized trials (2001) Eur J Anaesthesiol, 18 (6), pp. 346-357. , Jun, PMID: 11412287Scott, P.V., Fischer, H.B., Spinal opiate analgesia and facial pruritus: A neural theory (1982) Postgrad Med J, 58 (683), pp. 531-535. , Sep, PMID: 6755416Szarvas, S., Harmon, D., Murphy, D., Neuraxial opioid-induced pruritus: A review (2003) J Clin Anesth, 15 (3), pp. 234-239. , May, PMID: 1277066
Breast cancer in very young women—a multicenter 10-year experience
Background: Breast cancer (BC) is the most prevalent cancer in adult young women in Europe. Although rare, it is one of the leading causes of death in this age group. The aim of this study is to characterize a cohort of young women regarding tumor stage, biology, treatment and survival.
Patients and methods: We present a multicenter retrospective analysis of women <35 years of age, diagnosed with BC between 2008 and 2017. A total of 207 patients from five Portuguese centers were included, from whom 172 were eligible for analysis. Data were analyzed using IBM SPPSS statistics.
Results: Median age at diagnosis was 31 years. Fifty-one percent of tumors were hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative, 20% HR-positive/HER2-positive, 8% HR-negative/HER2-positive and 20% triple-negative BC. Twenty-two percent of patients were diagnosed in stage I, 26% stage II, 45% stage III and 6% had de novo metastatic cancer. Thirty-nine percent of patients were treated with neoadjuvant chemotherapy. Mean follow-up time was 64.9 months and overall survival at 5 years, of the entire cohort and metastatic patients, was 86.5% and 26%, respectively.
Conclusions: In our study we found similar population characteristics to other cohorts <35 years of age. To our
knowledge, this is one of the largest cohorts in very young women. BC in young women is an important issue and further studies are needed to provide better care and survivorship to patients.info:eu-repo/semantics/publishedVersio
Biological and economic performance of feedlot lambs feeding on diets with different energy densities
Comparação de métodos para estimar a acidez potencial mediante determinação do pH SMP em Organossolos da Serra do Espinhaço Meridional
Relação entre acidez e outros atributos químicos em solos com teores elevados de matéria orgânica
Consumo de nutrientes e desempenho de cordeiros em confinamento alimentados com dietas com polpa cítrica úmida prensada em substituição à silagem de milho
Aplicação de um sistema automatizado (ALES - Automated Land Evaluation System) na avaliação das terras das microrregiões de Chapecó e Xanxerê, Oeste Catarinense, para o cultivo de grãos
Performance and carcass traits of Santa Inês lambs finished with different sources of forage
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