INTERVENÇÃO DE ENFERMAGEM NO ESTRESSE DO CUIDADOR FAMILIAR DO IDOSO COM DEPENDÊNCIA: ESTUDO PILOTO

Objetivo: avaliar a eficácia de uma intervenção de enfermagem estruturada com base num programa psicoeducativo de gestão do estresse sobre estressores primários (sobrecarga), recursos (coping) e resultados (bem-estar emocional) do cuidador, e avaliação realizada pelos cuidadores e pelos enfermeiros sobre a ajuda da intervenção e sobre o material de apoio ao programa. Método: estudo piloto com 13 cuidadores de idosos em Portugal durante 5 semanas. Realizaram-se entrevistas para avaliar a intervenção e o material de apoio. Resultados: depois da intervenção, houve melhoria no coping, no bem-estar e na sobrecarga com diferença estatisticamente significativa na sobrecarga; dificuldades com a implementação da intervenção e uso do material de apoio. Conclusão: os cuidadores familiares revelaram que a intervenção ajudou-os na aprendizagem de novas estratégias de coping. Por parte dos enfermeiros, a intervenção ajudou-os a conhecer as dificuldades do cuidador, facilitando a abordagem holística do cuidado centrado no cuidador e no idoso.Descritores: Intervenção de enfermagem no domicílio. Estresse. Cuidador familiar. Idoso

Desenvolvimento de híbridos de triazenos anti-tumorais

Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019As doenças cancerígenas são apresentadas como principais causas de morte por todo o mundo. Apesar da evolução da terapêutica nos últimos anos, o Glioblastoma Multiforme e o melanoma metastático são tumores agressivos e de rápida progressão, e por isso, a terapêutica com quimioterapia continua a apresentar reduzida taxa de sobrevivência. O Temozolomide (TMZ), um pró-fármaco com estrutura de triazeno, responsável pela sua atividade anti-cancerígena é utilizado para o tratamento destes tumores. Apesar de apresentar propriedades farmacocinéticas favoráveis, tem sido associado ao aparecimento de resistência. A associação de outros fármacos com o TMZ continua sem demonstrar a eficácia desejada. A síntese de uma molécula com dois farmacóforos com mecanismos anti-tumorais diferentes tem demonstrado ser uma possível alternativa ao TMZ. Estes fármacos são denominados de fármacos Híbridos. Estes híbridos têm na sua constituição um agente metilante de DNA, Monometiltriazeno (MMT), e um ácido carboxílico de cadeia curta ,βinsaturado com função de inibidor de Histona Deacetilases (HDACi). O ácido cinâmico e alguns derivados têm sido estudados pelas suas propriedades farmacológicas, incluindo como anti-tumoral. Em estudos anteriores o ácido cinâmico demonstrou atividade como HDACi. Diversos métodos têm sido usados para a síntese deste tipo de compostos, com o objetivo de melhorar o rendimento e a rapidez da obtenção de produto, nomeadamente com a utilização de agentes de ativação de ácidos carboxílicos. O design de fármacos compreende atualmente um vasto conjunto de estudos que tem por base não só a análise do seu potencial terapêutico, como também dos seus possíveis mecanismos de toxicidade. Os compostos Híbridos derivados de ácidos carboxílicos ,βinsaturados, devido à sua estrutura, apresentam capacidade de funcionarem como aceitadores de Michael e por isso serem potencialmente tóxicos. No presente trabalho foram sintetizados compostos Híbridos constituídos por monometiltriazeno e ácido trans-cinâmico, recorrendo a um método de síntese que promovesse mais facilmente a formação da ligação amida, bem como a sua caracterização estrutural, e a ação anti-tumoral.Nowadays, cancer diseases are one of the main causes of death around the world. In spite of the therapeutics advances on the last few years, Glioblastoma Multiform and metastatic melanoma are still very aggressive tumours and with rapid progression. Due to these characteristics, the current chemotherapy treatments still present a low survival rate. Temozolomide (TMZ), a pro-drug that has a triazene structure responsible for its anticancer activity, is used as treatment for these type of tumours. Although it presents favourable pharmacokinetic properties, it has been associated to the appearance of mechanisms of resistance. The association of TMZ with other drugs still doesn´t show to be efficient enough. The synthesis of a molecule with two pharmacophores with different anti-tumour mechanisms has been shown to be a possible alternative to TMZ. These drugs, called Hybrid drugs have in their structures a DNA methylating agent, Monomethyl triazene (MMT), and a small chain ,β-unsaturated carboxylic acid that acts has a Histone Deacetilase inhibitor (HDACi). Several methods have been used for the synthesis of this kind of compounds, aiming to improve some aspects including: yield and the time spent to obtain the final product, like the use of carboxylic acids activating agents. Drug design includes a broad set of studies based not only in the analysis of their therapeutic potential but as well as their possible toxicity mechanisms. Hybrid compounds derivate from an ,β-unsaturated carboxylic acids present, due to their structure, the ability to function as Michael acceptors and therefore potentially be responsible for some mechanisms of toxicity. In this work project there were synthesised Hybrid compounds constituted by monomethyl triazene and trans-cinnamic acid moieties, with the use of a synthesis method that could easily promote the amid bond formation. The compounds synthesised were then studied and analysed concerning their structural characterization and anti-tumor mechanism.FFUL-iMedULisboa, Medicinal Chemistry Laboratory; Farmácia Carmo- Vila Real de Sto. António; Hospital do Espírito Santo, Évora E.P.E

Technological and non-technological trends in fashion eco-innovations

Purpose – The fashion industry is diverse and demands a high amount of resources and labor for itsoperation. It has powerful tools that can positively impact the environment and society as a whole. In this sense,it becomes necessary for fashion to adopt sustainable strategies quickly. One way would be the adoption of ecoinnovations by companies in the sector. The objective of this research is to identify the main eco-innovationinitiatives carried out by companies in the fashion sector and to verify what the trend is in the sector in relationto the types of eco-innovation, whether technological or non-technological in nature.Design/methodology/approach – To meet the objective, the sector’s sustainability reports are analyzedbased on the Global Reporting Initiative (GRI) initiative. The method used to treat the data is content analysis.The authors chose to use the GRI-G4 and GRI-Standards versions of the GRI structure, as they include topicsrelevant to its stakeholders. The analysis based on these criteria considers 18 reports prepared by fourcompanies (Cia Hering, Grupo Malwee, Dudalina and Lojas Renner).Findings – From the data analysis, it was noticed that eco-innovations of technological trends prevail inBrazilian fashion, in the first place, those of process (24.56%), followed by eco-innovations of product (10.53%).The pressure exerted by internal or external stakeholders will be fueled by the current scenario of sustainabledevelopment, positively influencing the adoption of eco-innovation. This characteristic can be attributed to thefashion sector, since technological eco-innovations overlap with non-technological ones in all the years thatmake up the analysis.Research limitations/implications – As limitations of this research, it is worth mentioning the availabilityof GRIs in the fashion sector. Even considering it a step forward, noting that larger companies support theadoption of these reports, it is important to highlight that only four companies make up the available database(Cia Hering, Lojas Renner, Dudalina and Malwee). From the adoption of the dissemination of sustainabilityreports by other organizations, the base could be expanded.Practical implications – From this study, practical questions emerge that can contribute to managers andcompanies in the Brazilian fashion sector. Initially, the focus on eco-innovations is predominantly related to thetechnological component, with an emphasis on process eco-innovations. In this sense, business actions seek toresolve the accusations normally attributed to the sector, such as the adoption of unsustainable practices. Forexample, in cotton production, firms use large amounts of pesticides and water, despite the sector beingaccused of not taking proper responsibility regarding sustainability related issues.Social implications – Investment in eco-innovations indicates a positive attitude and change resulting frompressure and the need to return the market to society’s demands for more sustainable production technologieswith less environmental impact. Originality/value – The originality of the study lies in the systematization of a GRI analysis model applied tomeasure eco-innovations in fashion. Through the applied methodology, it is possible to emphasize that ecoinnovations of technological trend prevail in the industry, first in processes and then in product development

A Nau Catarineta

UIDB/00657/2020 UIDP/00657/2020Cruzando registos, fontes e metodologias provenientes de diversos territórios disciplinares das ciências sociais e humanas, a obra reúne – no espaço simultaneamente uno, heterogéneo e pluridimensional da antologia – documentos textuais e iconográficos, artes plásticas, arquivos fotográficos e estudos críticos que visam mapear os elementos constitutivo de um imaginário marítimo atlântico entre a Idade Média e a época contemporânea. Esta volume dá continuidade a um primeiro volume já publicado (ISBN: 978-989-8968-04-3). No capítulo "Nau Catarineta" apresenta-se uma versão do romance "Nau Catarineta", recolhida no Brasil, no século XIX, por Sílvio Romero, acompanhada de arquivo fonográfico.publishersversionpublishe

Variáveis Individuais e Familiares na Psoríase:: Um estudo com Doentes e Parceiros

In this paper the relationship between morbility, quality of life, marital adjustment, family coping and body image in 101 psoriatic patients and 78 partners was investigated. The results showed a positive relationship between patients and partners variables on dyadic adjustment, coping and morbidity. Negative quality of life and body image in patients are associated to more morbidity in partners. Patients in combined treatment and phototherapy showed lower quality of life and less satisfaction with body image. Better dyadic adjustment and less anxiety in partners predict higher adjustment in patients. Satisfaction with body image predicts better quality of life in patients. The results of this study emphasize the need to involve partners in program´s interventions. Clinical implications of the results are presented.O presente trabalho avalia a Morbilidade, Qualidade de Vida, Ajustamento de Casal, Coping Familiar e Imagem Corporal em doentes com psoríase (n=101) e seus parceiros (n=78) considerando o tipo de tratamento e idade de início da doença. Os resultados revelaram uma relação positiva entre Ajustamento de Casal, Morbilidade e Coping nos doentes e as mesmas variáveis nos parceiros. Por sua vez, pior Qualidade de Vida no doente está associada a mais Morbilidade no parceiro.             O grupo com inicio da doença entre os 16 e os 30 anos apresentou mais Morbilidade. O grupo de tratamento combinado apresentou pior Qualidade de Vida e este juntamente com o da fototerapia apresentaram pior Imagem Corporal. Em termos de predictores, verificou-se que melhor Ajustamento de Casal e menor Ansiedade Estado no parceiro previam o Ajustamento de Casal no doente e que a satisfação com a Imagem Corporal previa melhor Qualidade de Vida no doente

Co-crystal of suberic acid and 1,2-bis(4-pyridyl)ethane: A new case of packing polymorphism

The polymorphic behaviour of a co-crystal composed of neutral suberic acid and 1, 2-bis(4-pyridyl)ethane is reported. A multidisciplinary approach has been employed, using thermal analysis methods (differential scanning calorimetry and polarized light thermomicroscopy), spectroscopic methods (infrared spectroscopy) and X-ray single crystal and powder diffraction. Two new polymorphs, I and III; have been identified, and for one of them the crystal structure has been elucidated and compared to that of a known polymorph, form II, showing that the assembling of the molecules in chains via H-bonds is a common feature of both polymorphs. Polymorph II, obtained by crystallization from an aqueous or ethanol solution or by grinding, undergoes a solid-solid transition to polymorph I, which melts at 180.5 °C. Upon cooling from the melt, polymorph I is obtained, and a solid-solid transformation also occurs, to polymorph III''. Polymorph III was obtained serendipitously in an attempt to prepare a Nd(III) complex. The relative stability of the three polymorphic forms was established