An effective method for refining predicted protein complexes based on protein activity and the mechanism of protein complex formation

BACKGROUND: Identifying protein complexes from protein-protein interaction network is fundamental for understanding the mechanism of cellular component and protein function. At present, many methods to identify protein complexes are mainly based on the topological characteristics or the functional similarity features, neglecting the fact that proteins must be in their active forms to interact with others and the formation of protein complex is following a just-in-time mechanism. RESULTS: This paper firstly presents a protein complex formation model based on the just-in-time mechanism. By investigating known protein complexes combined with gene expression data, we find that most protein complexes can be formed in continuous time points, and the average overlapping rate of the known complexes during the formation is large. A method is proposed to refine the protein complexes predicted by clustering algorithms based on the protein complex formation model and the properties of known protein complexes. After refinement, the number of known complexes that are matched by predicted complexes, Sensitivity, Specificity, and f-measure are significantly improved, when compared with those of the original predicted complexes. CONCLUSION: The refining method can discard the spurious proteins by protein activity and generate new complexes by just-in-time assemble mechanism, which can enhance the ability to predict complex

Novel approach to investigate η\eta decays via η′→ππη\eta'\rightarrow\pi\pi\eta

To avoid the impact from the background events directly from $e^+e^-$ annihilations or $J/\psi$ decays, we propose a novel approach to investigate $\eta$ decays, in particular for its rare or forbidden decays, by using $\eta^\prime\rightarrow\pi\pi\eta$ produced in $J/\psi$ decays at the $\tau-$charm factories. Based on the MC studies of a few typical decays, $\eta\rightarrow \pi\pi$, $\gamma l^+l^- (l= e, \mu)$, $l^+l^-$, as well as $l^+l^-\pi^0$, the sensitivities could be obviously improved by taking advantage of the extra constraint of $\eta^\prime$. Using one trillion $J/\psi$ events accumulated at the Super $\tau$-Charm facility, the precision on the investigation of $\eta$ decays could be improved significantly and the observation of the rare decay $\eta\rightarrow e^+e^-$ is even accessable.Comment: 7 pages, 6 figure

Giant Ferroelectric Polarization in Ultrathin Ferroelectrics via Boundary‐Condition Engineering

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138390/1/adma201701475.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138390/2/adma201701475_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138390/3/adma201701475-sup-0001-S1.pd