225 research outputs found
DxFormer: A Decoupled Automatic Diagnostic System Based on Decoder-Encoder Transformer with Dense Symptom Representations
Diagnosis-oriented dialogue system queries the patient's health condition and
makes predictions about possible diseases through continuous interaction with
the patient. A few studies use reinforcement learning (RL) to learn the optimal
policy from the joint action space of symptoms and diseases. However, existing
RL (or Non-RL) methods cannot achieve sufficiently good prediction accuracy,
still far from its upper limit. To address the problem, we propose a decoupled
automatic diagnostic framework DxFormer, which divides the diagnosis process
into two steps: symptom inquiry and disease diagnosis, where the transition
from symptom inquiry to disease diagnosis is explicitly determined by the
stopping criteria. In DxFormer, we treat each symptom as a token, and formalize
the symptom inquiry and disease diagnosis to a language generation model and a
sequence classification model respectively. We use the inverted version of
Transformer, i.e., the decoder-encoder structure, to learn the representation
of symptoms by jointly optimizing the reinforce reward and cross entropy loss.
Extensive experiments on three public real-world datasets prove that our
proposed model can effectively learn doctors' clinical experience and achieve
the state-of-the-art results in terms of symptom recall and diagnostic
accuracy.Comment: 7 pages, 4 figures, 3 table
Efficient Deep Reinforcement Learning via Adaptive Policy Transfer
Transfer Learning (TL) has shown great potential to accelerate Reinforcement
Learning (RL) by leveraging prior knowledge from past learned policies of
relevant tasks. Existing transfer approaches either explicitly computes the
similarity between tasks or select appropriate source policies to provide
guided explorations for the target task. However, how to directly optimize the
target policy by alternatively utilizing knowledge from appropriate source
policies without explicitly measuring the similarity is currently missing. In
this paper, we propose a novel Policy Transfer Framework (PTF) to accelerate RL
by taking advantage of this idea. Our framework learns when and which source
policy is the best to reuse for the target policy and when to terminate it by
modeling multi-policy transfer as the option learning problem. PTF can be
easily combined with existing deep RL approaches. Experimental results show it
significantly accelerates the learning process and surpasses state-of-the-art
policy transfer methods in terms of learning efficiency and final performance
in both discrete and continuous action spaces.Comment: Accepted by IJCAI'202
Predicting Parkinson's Disease Genes Based on Node2vec and Autoencoder
Identifying genes associated with Parkinson's disease plays an extremely important role in the diagnosis and treatment of Parkinson's disease. In recent years, based on the guilt-by-association hypothesis, many methods have been proposed to predict disease-related genes, but few of these methods are designed or used for Parkinson's disease gene prediction. In this paper, we propose a novel prediction method for Parkinson's disease gene prediction, named N2A-SVM. N2A-SVM includes three parts: extracting features of genes based on network, reducing the dimension using deep neural network, and predicting Parkinson's disease genes using a machine learning method. The evaluation test shows that N2A-SVM performs better than existing methods. Furthermore, we evaluate the significance of each step in the N2A-SVM algorithm and the influence of the hyper-parameters on the result. In addition, we train N2A-SVM on the recent dataset and used it to predict Parkinson's disease genes. The predicted top-rank genes can be verified based on literature study
Predicting Disease-Related Genes Using Integrated Biomedical Networks
Background: Identifying the genes associated to human diseases is crucial for disease diagnosis and drug design. Computational approaches, esp. the network-based approaches, have been recently developed to identify disease-related genes effectively from the existing biomedical networks. Meanwhile, the advance in biotechnology enables researchers to produce multi-omics data, enriching our understanding on human diseases, and revealing the complex relationships between genes and diseases. However, none of the existing computational approaches is able to integrate the huge amount of omics data into a weighted integrated network and utilize it to enhance disease related gene discovery.
Results: We propose a new network-based disease gene prediction method called SLN-SRW (Simplified Laplacian Normalization-Supervised Random Walk) to generate and model the edge weights of a new biomedical network that integrates biomedical data from heterogeneous sources, thus far enhancing the disease related gene discovery.
Conclusions: The experiment results show that SLN-SRW significantly improves the performance of disease gene prediction on both the real and the synthetic data sets
Circulating tumor DNA determining hyperprogressive disease after CAR-T therapy alarms in DLBCL: a case report and literature review
Chimeric antigen receptor T-cell therapy (CAR-T) has been widely applied in the clinical practice of relapse/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) due to its promising effects. Hyperprogressive disease (HPD) has gained attention for rapid tumor progression and has become a therapeutic and prognostic challenge. Here, we present a patient who had suffered from several recurrences previously and controlled well with a very small tumor lesion left was infused with CD19/CD22 bispecific CAR-T, with no immune effector cell-associated neurotoxicity syndrome, or cytokine release syndrome observed. However, rapid deterioration, subsequent imaging examination, circulating tumor DNA, and serum biomarkers detection identified HPD. The patient did not respond to salvage treatment and died 40 days after infusion. To our knowledge, only one case of HPD in DLBCL after CAR-T therapy has been reported. This fatal case alarmed the risk of HPD and the ctDNA profile monitoring we used was performed as a non-invasive method to diagnose HPD, providing far-reaching practical instruction for CAR-T therapy
The effect of helminth infection on the microbial composition and structure of the caprine abomasal microbiome
Haemonchus contortus is arguably the most injurious helminth parasite for small ruminants. We characterized the impact of H. contortus infection on the caprine abomasal microbiome. Fourteen parasite naive goats were inoculated with 5,000 H. contortus infective larvae and followed for 50 days. Six age-matched naïve goats served as uninfected controls. Reduced bodyweight gain and a significant increase in the abosamal pH was observed in infected goats compared to uninfected controls. Infection also increased the bacterial load while reducing the abundance of the Archaea in the abomasum but did not appear to affect microbial diversity. Nevertheless, the infection altered the abundance of approximately 19% of the 432 species-level operational taxonomic units (OTU) detected per sample. A total of 30 taxa displayed a significantly different abundance between control and infected goats. Furthermore, the infection resulted in a distinct difference in the microbiome structure. As many as 8 KEGG pathways were predicted to be significantly affected by infection. In addition, H. contortus-induced changes in butyrate producing bacteria could regulate mucosal inflammation and tissue repair. Our results provided insight into physiological consequences of helminth infection in small ruminants and could facilitate the development of novel control strategies to improve animal and human health
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