The ACS Exams Institute Undergraduate Chemistry Anchoring Concepts Content Map I: General Chemistry

To provide tools for programmatic assessment related to the use of ACS Exams in undergraduate chemistry courses, the ACS Exams Institute has built a content map that applies to the entire undergraduate curriculum. At the top two levels, the grain size of the content classification is large and spans the entire undergraduate curriculum. At the bottom two levels, the grain size of the content is more fine and tuned to specific course levels of the curriculum. This paper presents all four levels of the map as identified for first-year general chemistry

Cottrell Scholars Collaborative New Faculty Workshop: Professional Development for New Chemistry Faculty and Initial Assessment of Its Efficacy

The Cottrell Scholars Collaborative New Faculty Workshop (CSC NFW) is a professional development program that was initiated in 2012 to address absences in the preparation of chemistry faculty at research universities as funded researchers and educators (i.e., teacher–scholars). The primary focus of the workshop is an introduction to evidence-based teaching methods; other topics including mentoring, work–life balance, time management, and grant writing are also addressed. A longer-term aim of the workshop is to develop lifelong teacher–scholars by encouraging workshop participants to engage with teaching-focused faculty learning communities through the CSC NFW and at their institutions. The workshop also provides a platform to investigate the adoption of student-centered pedagogies among new faculty, and a study of that process was initiated concurrently. Thus, the aim of the workshop program is to address professional development needs as well as understand the efficacy of that effort

Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours

BACKGROUND: Hypoxia, which is commonly observed in areas of primary tumours and of metastases, influences response to treatment. However, its characterisation has so far mainly been restricted to the ex vivo analysis of tumour sections using monoclonal antibodies specific to carbonic anhydrase IX (CA IX) or by pimonidazole staining, after the intravenous administration of this 2-nitroimidazole compound in experimental animal models.METHODS: In this study, we describe the generation of high-affinity human monoclonal antibodies (A3 and CC7) specific to human CA IX, using phage technology.RESULTS: These antibodies were able to stain CA IX ex vivo and to target the cognate antigen in vivo. In one of the two animal models of colorectal cancer studied (LS174T), CA IX imaging closely matched pimonidazole staining, with a preferential staining of tumour areas characterised by little vascularity and low perfusion. In contrast, in a second animal model (SW1222), distinct staining patterns were observed for pimonidazole and CA IX targeting. We observed a complementary pattern of tumour regions targeted in vivo by the clinical-stage vascular-targeting antibody L19 and the anti-CA IX antibody A3, indicating that a homogenous pattern of in vivo tumour targeting could be achieved by a combination of the two antibodies.CONCLUSION: The new human anti-CA IX antibodies are expected to be non-immunogenic in patients with cancer and may serve as broadly applicable reagents for the non-invasive imaging of hypoxia and for pharmacodelivery applications. British Journal of Cancer (2009) 101, 645-657. doi: 10.1038/sj.bjc.6605200 www.bjcancer.com Published online 21 July 2009 (C) 2009 Cancer Research U

A chronoamperometric method to estimate changes in the membrane composition of ion-selective membranes

A new chronoamperometric method is used to estimate changes in the membrane composition of mobile-site, ionophore-based membranes. The characteristic features of the chronoamperometric curves (initial current, slope, break time) of valinomycin-based, potassium-selective membranes loaded with potassium tetrakis(4-chlorophenyl)borate are correlated with the mobile-site and free ionophore concentration in the membrane. Limiting cases for strong and negligible ion pair formation are distinguished. Replicate measurements indicate a relative standard deviation in the calculated values less than 10%. The practical applicability of the method was tested with membranes incorporated into conventional ion-selective electrode bodies or cast onto microfabricated planar sensor structures

Voltammetric Determination of Diffusion Coefficients in Polymer Membranes: Guidelines to Minimize Errors

Diffusion coefficients are important in the design, optimization, and selection of membranes used in many applications including chemical and biosensors. Since the diffusion-controlled transport of the analyte and interfering ions and molecules through polymer membranes may affect the rate of response, detection limit, selectivity, lifetime, etc. of chemical and biosensors, having a rapid and accurate method for the determination of diffusion coefficients of different compounds in a variety of membranes is uniquely important. In our contribution, we present a simple protocol for the rapid determination of the diffusion coefficients of electrochemically active analytes by linear sweep voltammetry. The expected errors in the estimated coefficients have been analyzed through modeling and the correlation between the magnitude of the unknown diffusion coefficients and the method\u27s related maximum error is presented as a contour plot for different working electrode dimensions. It is also shown that our analysis protocol can be used to estimate the diffusion coefficient in complex membrane matrices and non-ideal experimental conditions with a maximum systematic error of 14 % even without any experimental parameter optimization

IMACCS: A Progress Report on NASA/GSFC's COTS-Based Ground Data Systems, and Their Extension into New Domains

International Telemetering Conference Proceedings / October 28-31, 1996 / Town and Country Hotel and Convention Center, San Diego, CaliforniaThe Integrated Monitoring, Analysis, and Control COTS System (IMACCS), a system providing real time satellite command and telemetry support, orbit and attitude determination, events prediction, and data trending, was implemented in 90 days at NASA Goddard Space Flight Center (GSFC) in 1995. This paper describes upgrades made to the original commercial, off-the-shelf (COTS)-based prototype. These upgrades include automation capability and spacecraft Integration and Testing (I&T) capability. A further extension to the prototype is the establishment of a direct RF interface to a spacecraft. As with the original prototype, all of these enhancements required lower staffing levels and reduced schedules compared to custom system development approaches. The team's approach to system development, including taking advantage of COTS and legacy software, is also described.International Foundation for TelemeteringProceedings from the International Telemetering Conference are made available by the International Foundation for Telemetering and the University of Arizona Libraries. Visit http://www.telemetry.org/index.php/contact-us if you have questions about items in this collection