19 research outputs found
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
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- Andres C
- Andresen D
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- Vogel CHIARA EUGENIA
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- Yandamuri S
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- Zhang Ting
- Zhang Wen
- Zhang X
- Zhang Y
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- Zhao L
- Zhao P
- Zhao R
- Zhao Y
- Zheng Y
- Zheng Z
- Zhi Y
- Zhong H
- Zhong R
- Zhou C
- Zhou Juan
- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
- Zhu X
- Zhu Y
- Ziefle S
- Zilz N
- Zineldine A
- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
WEST AFRICAN STRANGERS IN BRAZZAVILLE - Migrants and Strangers in an African City: Exile, Dignity, Belonging. By Bruce Whitehouse. Bloomington, IN: Indiana University Press, 2012. Pp. x+274. $25, paperback ( isbn
- Author
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
African Women in Towns: an aspect of Africa's social revolution by Kenneth Little Cambridge University Press, 1973. Pp. viii+242. £4.90 £1.90 paperback. 4.95.−WomenandPropertyinMorocco:theirchangingrelationtotheprocessofsocialstratificationintheMiddleAtlasbyVanessaMaherCambridgeUniversityPress,1974.Pp.xii+238.£5.00.14.95. - Marriage among a Matrilineal Elite: a family study of Ghanaian senior civil servants by Christine Oppong Cambridge University Press, 1975. Pp. xvi+187. £4.50. $13.95.
- Author
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
The Development of Islam in West Africa by Mervyn Hiskett London and New York, Longman, 1984. Pp. xiii+353. £19.95. £6.95 paperback.
- Author
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
Male praise-singers in Accra: in the company of women
- Author
- Publication venue
- 'JSTOR'
- Publication date
- Field of study
Worksites as Sacrifice Zones: Structural Precarity and COVID-19 in U.S. Meatpacking
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Bedroom Personalization by Urban Adolescents in Botswana: Developing Place Attachment
- Author
- Abbott-Chapman Joan
- Abbott-Chapman Joan
- Beck Ulrich
- Brown Barbara
- Brown Barbara
- Chatterjee Sudeshna
- Chawla Louise
- Chipuer Heather M.
- Cooper Marcus C.
- Denzin Norman
- Derr Victoria
- Grant Sandy
- Hay Robert
- Hernandez Bernado
- James Kandy
- Jorgensen Bradley
- Kamptner Laura
- Kruger Fred
- Kyle Gerard
- Larsson Anita
- Larsson Anita
- Lincoln Yvonne
- Livingstone Sonia
- Low Setha M.
- Low Setha M.
- Nanzer Bruce
- Neuman Lawrence W.
- Nilan Pam
- Omata Kenji
- Pellow Deborah
- Scannell Leila
- Stedman Richard
- Steele Jeanne
- Stokols Daniel
- Taylor Denise
- Publication venue
- 'Children, Youth and Environments Center'
- Publication date
- 01/01/2012
- Field of study
Urban Life-Worlds in Motion: In Africa and Beyond
- Author
- Basu Paul
- Behrens Roger
- Boesen Elisabeth
- Boyer Florence
- Carling Jørgen
- Casey Edward S.
- Catherine Coquery-Vidrovitch
- Clifford James
- Cohen Abner
- Davis Mike
- De Boeck Filip
- Drechsel Pay
- Epstein Arnold L.
- Ferguson James
- Garcia Canclini Néstor
- Genova James E.
- Glick Schiller Nina
- Glick Schiller Nina
- Gugler Josef
- Gutkind Peter C. W.
- Guèye Cheikh
- Hackenbroich Wilfried
- Hahn Hans Peter
- Heeg Susanne
- Horn David G.
- Idrissou Mora-Kpai
- Jacqueline Copeland-Carson
- Kastner Kristin
- Klute Georg
- Koolhaas Rem
- Lefebvre Henri
- Lentz Carola
- Levitt Peggy
- MacGaffey Janet
- Malaquais Dominique
- Marris Peter
- Mazzucato Valentina
- Mitchell James Clyde
- Mitchell James Clyde
- Moore Sally F.
- Murray Martin J.
- Nieswand Boris
- Nutall Sarah
- Otiso Kefa M.
- Paragas Fernando
- Pelican Michaela
- Pellow Deborah
- Pellow Deborah
- Pieterse Edgar
- Salazar Noel B.
- Sinatti Giulia
- Skinner Elliott P.
- Smith Michael P.
- Smith Michael P.
- Stoller Paul
- Swiaczny Frank
- Syed Ali
- UN-Habitat
- Vertovec Steven
- Vincent Cédric
- Waldenfels Bernhard
- Weiss Brad
- Weiss Brad
- Wildner Kathrin
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study