Behavior and neuropsychiatric manifestations in Angelman syndrome

Angelman syndrome has been suggested as a disease model of neurogenetic developmental condition with a specific behavioral phenotype. It is due to lack of expression of the UBE3A gene, an imprinted gene located on chromosome 15q. Here we review the main features of this phenotype, characterized by happy demeanor with prominent smiling, poorly specific laughing and general exuberance, associated with hypermotor behavior, stereotypies, and reduced behavioral adaptive skills despite proactive social contact. All these phenotypic characteristics are currently difficult to quantify and have been subject to some differences in interpretation. For example, prevalence of autistic disorder is still debated. Many of these features may occur in other syndromic or nonsyndromic forms of severe intellectual disability, but their combination, with particularly prominent laughter and smiling may be specific of Angelman syndrome. Management of problematic behaviors is primarily based on behavioral approaches, though psychoactive medication (eg, neuroleptics or antidepressants) may be required

The Lessons from Angelman Syndrome for Research and Management

info:eu-repo/semantics/publishe

High-dimensional coherent one-way quantum key distribution

High-dimensional quantum key distribution (QKD) offers secure communication, with secure key rates that surpass those achievable by QKD protocols utilizing two-dimensional encoding. However, existing high-dimensional QKD protocols require additional experimental resources, such as multiport interferometers and multiple detectors, thus raising the cost of practical high-dimensional systems and limiting their use. Here, we present and analyze a novel protocol for arbitrary-dimensional QKD, that requires only the hardware of a standard two-dimensional system. We provide security proofs against individual attacks and coherent attacks, setting an upper and lower bound on the secure key rates. Then, we test the new high-dimensional protocol in a standard two-dimensional QKD system over a 40 km fiber link. The new protocol yields a two-fold enhancement of the secure key rate compared to the standard two-dimensional coherent one-way protocol, without introducing any hardware modifications to the system. This work, therefore, holds great potential to enhance the performance of already deployed time-bin QKD systems through a software update alone. Furthermore, its applications extend across different encoding schemes of QKD qudits

Analyse d'un questionnaire sur les habitudes de consommation de boissons alcoolisées: cornparaison entre un groupe de patients alcooliques et un groupe de sujets témoins

SCOPUS: ar.jFLWNAinfo:eu-repo/semantics/publishe

Analyse d'un questionnaire sur les habitudes de consommation de boissons alcoolisées

info:eu-repo/semantics/publishe

Application de l'analyse typologique et de l'analyse binaire classique à l'étude d'un questionnaire relatif aux habitudes de prise de boissons alcoolisées

info:eu-repo/semantics/publishe

Abroad-spectrum psychotherapeutic technique in alcoholism

info:eu-repo/semantics/nonPublishe

Drinking patterns in the course of alcoholism

info:eu-repo/semantics/nonPublishe

Résultats du traitement de patients alcooliques pharmaco dépendants traités en hospitalisation médicale non psychiatrique

SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe