Two-tier channel estimation aided near-capacity MIMO transceivers relying on norm-based joint transmit and receive antenna selection

We propose a norm-based joint transmit and receive antenna selection (NBJTRAS) aided near-capacity multiple-input multiple-output (MIMO) system relying on the assistance of a novel two-tier channel estimation scheme. Specifically, a rough estimate of the full MIMO channel is first generated using a low-complexity, low-training-overhead minimum mean square error based channel estimator, which relies on reusing a modest number of radio frequency (RF) chains. NBJTRAS is then carried out based on this initial full MIMO channel estimate. The NBJTRAS aided MIMO system is capable of significantly outperforming conventional MIMO systems equipped with the same modest number of RF chains, while dispensing with the idealised simplifying assumption of having perfectly known channel state information (CSI). Moreover, the initial subset channel estimate associated with the selected subset MIMO channel matrix is then used for activating a powerful semi-blind joint channel estimation and turbo detector-decoder, in which the channel estimate is refined by a novel block-of-bits selection based soft-decision aided channel estimator (BBSB-SDACE) embedded in the iterative detection and decoding process. The joint channel estimation and turbo detection-decoding scheme operating with the aid of the proposed BBSB-SDACE channel estimator is capable of approaching the performance of the near-capacity maximumlikelihood (ML) turbo transceiver associated with perfect CSI. This is achieved without increasing the complexity of the ML turbo detection and decoding process

Analysis of electromagnetic forces of large turbine generators

A new approach to calculate and analyze the electromagnetic forces on end windings of large turbine generators is presented. This approach, so-called the quasi-three-dimensional (quasi-3-D) finite-element method (FEM), takes advantages over the conventional 3-D FEM in memory size and time-efficiency. The distributions of the electromagnetic field and forces on end windings of a 100 MW generator are analyzed. Incorporating advanced computer graphics, the analysis can be carried out under visual and interactive environment. The theoretical results are experimentally verified.link_to_subscribed_fulltex

Caveolin-1 promotes glioma proliferation and metastasis by enhancing EMT via mediating PAI-1 activation and its correlation with immune infiltrates

Glioma is typically characterized by a poor prognosis and is associated with a decline in the quality of life as the disease advances. However, the development of effective therapies for glioma has been inadequate. Caveolin-1 (CAV-1) is a membrane protein that plays a role in caveolae formation and interacts with numerous signaling proteins, compartmentalizing them in caveolae and frequently exerting direct control over their activity through binding to its scaffolding domain. Although CAV-1 is a vital regulator of tumour progression, its role in glioma remains unclear. Our findings indicated that the knockdown of CAV-1 significantly inhibits the proliferation and metastasis of glioma. Subsequent mechanistic investigations demonstrated that CAV-1 promotes proliferation and metastasis by activating the photoshatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. Furthermore, we demonstrated that CAV-1 overexpression upregulates the expression of serpin peptidase inhibitor, class E, member 1 (SERPINE1, also known as PAI-1), which serves as a marker for the epithelial-mesenchymal transition (EMT) process. Further research showed that PAI-1 knockdown abolished the CAV-1 mediated activation of PI3K/Akt signaling pathway. In glioma tissues, CAV-1 expression exhibited a correlation with unfavorable prognosis and immune infiltration among glioma patients. In summary, our study provided evidence that CAV-1 activates the PI3K/Akt signaling pathway by upregulating PAI-1, thereby promoting the proliferation and metastasis of glioma through enhanced epithelial-mesenchymal transition (EMT) and angiogenesis, and CAV-1 is involved in the immune infiltration

Anticancer Activity of Polysaccharides Produced from Glycerol and Crude Glycerol by an Endophytic Fungus <i>Chaetomium</i> <i>globosum</i> CGMCC 6882 on Human Lung Cancer A549 Cells

Two polysaccharides were produced by Chaetomium globosum CGMCC 6882 from glycerol (GCP-1) and crude glycerol (GCP-2). Chemical characteristics results showed GCP-1 and GCP-2 were similar polysaccharides, but the molecular weights of GCP-1 and GCP-2 were 5.340 &#215; 104 Da and 3.105 &#215; 104 Da, respectively. Viabilities of A549 cells after treatment with GCP-1 and GCP-2 were 49% and 39% compared to the control group. Meanwhile, flow cytometry results indicated that GCP-1 and GCP-2 could induce 17.79% and 24.28% of A549 cells to apoptosis with 200 &#956;g/mL concentration treated for 24 h. RT-PCR results suggested that GCP-1 and GCP-2 could be used as potential and effective apoptosis inducers on A549 cells by increasing BAX, CASPASE-3, CASPASE-9, TIMP-1, TIMP-2 expression and decreasing BCL-2 expression. This research provided an innovative approach to using a byproduct of biodiesel production (crude glycerol) to produce polysaccharides of potential medicinal benefit

Association between dietary fatty acids and urinary incontinence

Background: Dietary nutrient intake contributes to urination; however, the association between dietary nutrient intake, especially that of fat, and urinary incontinence (UI) is not well understood. The most common types of UI include stress UI (SUI) and urgency UI (UUI). Objective: To investigate the potential effect(s) of dietary fat intake on UI and explore its mechanism of action in relation to body mass index (BMI). Methods: A cross-sectional survey of data from 15,121 individuals (20–85 years of age) from the National Health and Nutrition Examination Survey (2001–2008), a random population-based sample, was performed. Data regarding dietary nutrient intake were collected through 24 h dietary recall interviews. UI and covariate data were collected through in-person interviews. UI was assessed according to the American Urological Association Symptom Index. The odds ratio (OR) for SUI and UUI were calculated using multivariate logistic regression analysis. The mediation effect was estimated using observational mediation analysis. Results: Higher total fat intake was positively associated with increased odds for developing UI (OR 1.44 [95% confidence interval (CI) 1.08–1.93]). Females who consumed more saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA) were more likely to develop SUI. BMI partially explained the association between total fat, SFA, MUFA, and PUFA and SUI; the proportions of the mediation effect of BMI were 14.7%, 13.0%, 18.7%, and 16.3%, respectively. Conclusions: Results of this study emphasize the key role of dietary fat intake in the prevalence of UI. Higher fat intake was positively associated with UI and BMI partially mediated the effect of fat intake on SUI