Can ESG investments and new environmental law improve social happiness in China?

Air pollution was a serious issue in China in the early 2010s, threatening public health and sustainable economic development. The Chinese government established a new environmental protection law in 2015 in order to address air pollution and other environmental issues. This paper investigates the impact of the new environmental law and ESG investments on air pollution and social happiness. We discovered that the implementation of the new environmental law and ESG investments significantly improved social happiness by reducing air pollution. One unit increase in ESG investments would result in a 0.334 unit decrease in air pollution and 0.225 unit increase in social happiness

Regional activity alterations in Parkinson’s disease patients with anxiety disorders: A resting-state functional magnetic resonance imaging study

BackgroundPrevious studies have revealed alteration of functional connectivity (FC) in Parkinson’s disease patients with anxiety (PD-A), but local brain activities associated with anxiety in Parkinson’s disease (PD) patients remain to be elucidated. Regional homogeneity (ReHo) analysis was employed to investigate alterations of regional brain activities in PD-A patients.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 42 PD-A patients, 41 PD patients without anxiety (PD-NA), and 40 age-and gender-matched healthy control (HC) subjects. ReHo analysis was used to investigate the synchronization of neuronal activities in brain regions in the three groups. The relationship between ReHo value and anxiety score in the PD-A group was also investigated.ResultsParkinson’s disease patients with anxiety showed increased ReHo values in the bilateral frontal lobes, caudate nucleus, and anterior cingulate gyrus [Gaussian random field (GRF) correction, voxel size p < 0.01, cluster size p < 0.05], compared with PD-NA patients and HC subjects, but the ReHo values of the right cerebellar hemisphere and posterior cerebellar lobe decreased (GRF correction, voxel size p < 0.01, cluster size p < 0.05). The increased ReHo values of the right superior frontal gyrus (r = 0.633, p = 0.001) and anterior cingulate gyrus (r = 0.45, p = 0.01) were positively correlated with anxiety scores in PD-A patients.ConclusionThe development of PD-A may be associated with dysfunctional local activities in multiple brain regions, including the frontal cortex, cerebella, basal ganglia, and limbic system. Abnormal ReHo values in these brain regions may serve as neuroimaging markers for the early diagnosis of PD-A. The results suggest that using ReHo analysis to identify functional changes in core regions may advance our understanding of the pathophysiological mechanisms underlying PD-A

Disitamab Vedotin (RC48) for HER2-positive advanced breast cancer: a case report and literature review

Background/aimHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer is associated with a higher risk of metastasis and poorer overall survival (OS) due to HER2 gene overexpression/amplification. Although anti-HER2 targeted therapy has shown survival benefits in HER2-positive advanced breast cancer (ABC) patients, long-term treatment often leads to drug resistance, complicating further treatment options. RC48, an antibody-drug conjugate (ADC), combines the benefits of antibody targeting with the cytotoxic effects of a small molecule drug.Case reportWe present a case involving a female patient with HER2-positive ABC who developed drug resistance and disease progression following multi-line anti-HER2 targeted therapy. In this instance, RC48 exhibited anti-tumor activity in an ABC patient resistant to HER2-targeted therapy. After eight treatment cycles with 120 mg of RC48, the tumor size decreased and stabilized.ConclusionThis case report underscores the potential clinical value of RC48 as a promising treatment alternative for patients resistant to HER2 targeted therapies

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Optimal tripartite quantum teleportation protocols via noisy channels by feed-forward control and environment-assisted measurement

This paper presents a tripartite quantum teleportation protocol that incorporates feed-forward control and environment-assisted measurement, aiming to suppress the influence of arbitrary noise with at least one reversible Kraus operator. In this protocol, the feed-forward control is first utilized before the decoherence channel, such that the entangled qubit is transferred to the target state, which is more robust against noise. Next, the measurement is performed on the noise environment coupled with the entangled qubit during the decoherence channel. Finally, the reversed feed-forward control and the redesigned weak measurement reversal operator are applied after the decoherence channel. This protocol can be applied to the case where both amplitude damping and phase damping noise coexist. Based on this protocol, the analytical expressions for performance metrics including the average fidelity and the success probability are further derived. Even for the heavy damping cases, the final average teleportation fidelity can reach 1, which is independent of the magnitude of decoherence and the entanglement parameters. Furthermore, we optimize the success probability without compromising fidelity, and derive the average fidelity expression of the standard tripartite teleportation protocol through the phase damping noise channel. The effectiveness of our protocol is verified by numerical simulations

Compound Vector Light Generator Based on a Metasurface

In view of wide applications of vector light with a non-uniform polarization state, a compound vector light generator is proposed to generate compound vector light. One compound vector light contains two or more non-uniform polarization modes and several annular intensities, which can carry more polarization information and possess higher dimensional singularity. The proposed compound vector light generator consists of cross nanoholes with high polarization conversion efficiency; it works under linear polarized light, and the mode of the generated compound vector light can be adjusted through rotating cross nanoholes. The structure parameters of the compound vector light generator are optimized with the aid of numerical simulation, and the simulation results for the generated light fields verify the performance of the proposed device. The advancement of the compound vector light and metasurface design of the compound vector light generator can assist in the exploration of novel singular properties of light fields and the broadening of applications of vector light fields

Performance Analysis of Metalenses Based on Three Kinds of Phase Compensation Techniques

The phase delays introduced by anisotropic nanounits include propagation phase delay, resonant phase delay and geometric phase delay. Various phase devices can be formed based on the metasurfaces consisting of anisotropic nanounits and the phase devices of the same kind function have different performances because of different working modes. In this paper, metalenses and vortex metalenses are chosen as examples to compare the optical performance of metasurface phase devices based on three kinds of phase compensation techniques. We design separately three kinds of metalenses and vortex metalenses using the cross nanoholes, L-shaped nanohole and V-shaped nanoholes and simulate numerically their intensity and phase distributions. Additionally, the results show the differences among these elements in structure complexity, polarization dependence, working efficiency and phase uniformity. The comparison for three kinds of metalenses clearly shows the merits of different phase compensation techniques and this work must be helpful for expanding the practical applications of metasurfaces