Higgs Phenomenology in the Minimal Dilaton Model after Run I of the LHC

The Minimal Dilaton Model (MDM) extends the Standard Model (SM) by a singlet scalar, which can be viewed as a linear realization of general dilaton field. This new scalar field mixes with the SM Higgs field to form two mass eigenstates with one of them corresponding to the 125 GeV SM-like Higgs boson reported by the LHC experiments. In this work, under various theoretical and experimental constrains, we perform fits to the latest Higgs data and then investigate the phenomenology of Higgs boson in both the heavy dilaton scenario and the light dilaton scenario of the MDM. We find that: (i) If one considers the ATLAS and CMS data separately, the MDM can explain each of them well, but refer to different parameter space due to the apparent difference in the two sets of data. If one considers the combined data of the LHC and Tevatron, however, the explanation given by the MDM is not much better than the SM, and the dilaton component in the 125-GeV Higgs is less than about 20% at 2 sigma level. (ii) The current Higgs data have stronger constrains on the light dilaton scenario than on the heavy dilaton scenario. (iii) The heavy dilaton scenario can produce a Higgs triple self coupling much larger than the SM value, and thus a significantly enhanced Higgs pair cross section at hadron colliders. With a luminosity of 100 fb^{-1} (10 fb^{-1}) at the 14-TeV LHC, a heavy dilaton of 400 GeV (500 GeV) can be examined. (iv) In the light dilaton scenario, the Higgs exotic branching ratio can reach 43% (60%) at 2 sigma (3 sigma) level when considering only the CMS data, which may be detected at the 14-TeV LHC with a luminosity of 300 fb^{-1} and the Higgs Factory.Comment: 27 pages, 13 figures, discussions added, to appear in JHE

Web Annotation Systems: A Literature Review and Case Study

Web annotation has been a popular research topic since the appearance of Internet and its supplementary technologies. This paper provides a literature review in the related research areas, and introduces some currently available web annotation systems with the comparison of these systems in seven aspects. In addition, this paper incorporates a description of the ongoing NeoNote project, and identifies limitations of this study for future work

Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma

IntroductionThe conflict between cancer cells and the host immune system shapes the immune tumour microenvironment (TME) in hepatocellular carcinoma (HCC). A deep understanding of the heterogeneity and intercellular communication network in the TME of HCC will provide promising strategies to orchestrate the immune system to target and eradicate cancers.MethodsHere, we performed single-cell RNA sequencing (scRNA-seq) and computational analysis of 35786 unselected single cells from 3 human HCC tumour and 3 matched adjacent samples to elucidate the heterogeneity and intercellular communication network of the TME. The specific lysis of HCC cell lines was examined in vitro using cytotoxicity assays. Granzyme B concentration in supernatants of cytotoxicity assays was measured by ELISA.ResultsWe found that VCAN+ tumour-associated macrophages (TAMs) might undergo M2-like polarization and differentiate in the tumour region. Regulatory dendritic cells (DCs) exhibited immune regulatory and tolerogenic phenotypes in the TME. Furthermore, we observed intensive potential intercellular crosstalk among C1QC+ TAMs, regulatory DCs, regulator T (Treg) cells, and exhausted CD8+ T cells that fostered an immunosuppressive niche in the HCC TME. Moreover, we identified that the TIGIT-PVR/PVRL2 axis provides a prominent coinhibitory signal in the immunosuppressive TME. In vitro, antibody blockade of PVR or PVRL2 on HCC cell lines or TIGIT blockade on immune cells increased immune cell-mediated lysis of tumour cell. This enhanced immune response is paralleled by the increased secretion of Granzyme B by immune cells.DiscussionCollectively, our study revealed the functional state, clinical significance, and intercellular communication of immunosuppressive cells in HCC at single-cell resolution. Moreover, PVR/PVRL2, interact with TIGIT act as prominent coinhibitory signals and might represent a promising, efficacious immunotherapy strategy in HCC

Speculation on optimal numbers of examined lymph node for early-stage epithelial ovarian cancer from the perspective of stage migration

IntroductionIn early-stage epithelial ovarian cancer (EOC), how to perform lymphadenectomy to avoid stage migration and achieve reliable targeted excision has not been explored in depth. This study comprehensively considered the stage migration and survival to determine appropriate numbers of examined lymph node (ELN) for early-stage EOC and high-grade serous ovarian cancer (HGSOC).MethodsFrom the Surveillance, Epidemiology, and End Results database, we obtained 10372 EOC cases with stage T1M0 and ELN ≥ 2, including 2849 HGSOC cases. Generalized linear models with multivariable adjustment were used to analyze associations between ELN numbers and lymph node stage migration, survival and positive lymph node (PLN). LOESS regression characterized dynamic trends of above associations followed by Chow test to determine structural breakpoints of ELN numbers. Survival curves were plotted using Kaplan-Meier method.ResultsMore ELNs were associated with more node-positive diseases, more PLNs and better prognosis. ELN structural breakpoints were different in subgroups of early-stage EOC, which for node stage migration or PLN were more than those for improving outcomes. The meaning of ELN structural breakpoint varied with its location and the morphology of LOESS curve. To avoid stage migration, the optimal ELN for early-stage EOC was 29 and the minimal ELN for HGSOC was 24. For better survival, appropriate ELN number were 13 and 8 respectively. More ELNs explained better prognosis only at a certain range.DiscussionNeither too many nor too few numbers of ELN were ideal for early-stage EOC and HGSOC. Excision with appropriate numbers of lymph node draining the affected ovary may be more reasonable than traditional sentinel lymph node resection and systematic lymphadenectomy

Single cell atlas for 11 non-model mammals, reptiles and birds.

The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the expression patterns of viral entry genes in different hosts. However, such exploration for SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing for 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat and rabbit), poultry (duck and pigeon), and wildlife (pangolin, tiger, and deer), and investigated the co-expression of ACE2 and TMPRSS2. Furthermore, cross-species analysis of the lung cell atlas of the studied mammals, reptiles, and birds reveals core developmental programs, critical connectomes, and conserved regulatory circuits among these evolutionarily distant species. Overall, our work provides a compendium of gene expression profiles for non-model animals, which could be employed to identify potential SARS-CoV-2 target cells and putative zoonotic reservoirs

Research on Quantitative Assessment and Dynamic Reasoning Method for Emergency Response Capability in Prefabricated Construction Safety

In response to the common issues of lacking a comprehensive quantitative assessment system and insufficient dynamic understanding of emergency response capability in prefabricated construction safety, this study proposes a research methodology based on decision-making trial and evaluation laboratory (DEMATEL) and fuzzy cognitive maps (FCM) to promote the construction of emergency response capacity. Firstly, a quantitative evaluation indicator system comprising 4 core categories of organizational management, personnel quality, technical measures, and emergency resources, along with 16 main categories, is established using grounded theory and three levels of coding approach. Subsequently, through a combination of expert surveys and quantitative analysis, DEMATEL is employed to unveil the causal relationships and key indicators of the evaluation criteria. Next, the DEMATEL and FCM models are integrated to conduct predictive and diagnostic reasoning analysis based on key indicators. Finally, a case study is conducted to validate the usability and effectiveness of the proposed model and methodology. The results demonstrate that indicators related to organizational management and personnel quality belong to the cause group, while technical measures and emergency resources fall into the effect group. The “completeness of emergency plans” exhibits the most significant influence on other indicators and is also the most influenced indicator by others. Predictive reasoning analysis reveals that well-controlled “emergency organizational structure and procedures” are crucial for enhancing emergency response capacity. Diagnostic reasoning analysis indicates that the improvement of emergency response capability should focus on enhancing the “completeness of emergency plans”. The synergistic effect between “emergency organizational structure and procedures” and “completeness of emergency plans” contributes to the enhancement of emergency response capability in prefabricated construction safety. The study holds both theoretical and practical significance for advancing safety management in prefabricated construction. Considering the dynamic coupling of multiple factors will be the primary direction of research in the field of safety management in the future