The epidemiological patterns of non-Hodgkin lymphoma: global estimates of disease burden, risk factors, and temporal trends

BackgroundThe incidence of non-Hodgkin’s lymphoma (NHL) has increased steadily over the past few decades. Elucidating its global burden will facilitate more effective disease management and improve patient outcomes. We explored the disease burden, risk factors, and trends in incidence and mortality in NHL globally.MethodsThe up-to-date data on age-standardized incidence and mortality rates of NHL were retrieved from the GLOBOCAN 2020, CI5 volumes I-XI, WHO mortality database, and Global Burden of Disease (GBD) 2019, focusing on geographic disparities worldwide. We reported incidence and mortality by sex and age, along with corresponding age-standardized rates (ASRs), the average annual percentage change (AAPC), and future burden estimates to 2040.ResultsIn 2020, there were an estimated 545,000 new cases and 260,000 deaths of NHL globally. In addition, NHL resulted in 8,650,352 age-standardized DALYs in 2019 worldwide. The age-specific incidence rates varied drastically across world areas, at least 10-fold in both sexes, with the most pronounced increase trend found in Australia and New Zealand. By contrast, North African countries faced a more significant mortality burden (ASR, 3.7 per 100,000) than highly developed countries. In the past decades, the pace of increase in incidence and mortality accelerated, with the highest AAPC of 4.9 (95%CI: 3.6-6.2) and 6.8 (95%CI: 4.3-9.2) in the elderly population, respectively. Considering risk factors, obesity was positively correlated with age-standardized incidence rates (P< 0.001). And North America was the high-risk region for DALYs due to the high body mass index in 2019. Regarding demographic change, NHL incident cases are projected to rise to approximately 778,000 by 2040.ConclusionIn this pooled analysis, we provided evidence for the growing incidence trends in NHL, particularly among women, older adults, obese populations, and HIV-infected people. And the marked increase in the older population is still a public health issue that requires more attention. Future efforts should be directed at cultivating health awareness and formulating effective and locally tailored cancer prevention strategies, especially in most developing countries

Alternative buffer layer development in Cu(In,Ga)Se2 thin film solar cells

Shafarman, WilliamCu(In,Ga)Se2-based thin film solar cells are considered to be one of the most promising photovoltaic technologies. Cu(In,Ga)Se2 (CIGS) solar devices have the potential advantage of low-cost, fast fabrication by using semiconductor layers of only a few micrometers thick and high efficiency photovoltaics have been reported at both the cell and the module levels. CdS via chemical bath deposition (CBD) has been the most widely used buffer option to form the critical junction in CIGS-based thin film photovoltaic devices. However, the disadvantages of CdS can’t be ignored - regulations on cadmium usage are getting stricter primarily due to its toxicity and environmental impacts, and the proper handling of the large amount of toxic chemical bath waste is a massive and expensive task. ☐ This dissertation is devoted to the development of Cd-free alternative buffer layers in CIGS-based thin film solar cells. Based on the considerations of buffer layer selection criteria and extensive literature review, Zn-compound buffer materials are chosen as the primary investigation candidates. Radio frequency magnetron sputtering is the preferred buffer deposition approach since it’s a clean and more controllable technique compared to CBD, and is readily scaled to large area manufacturing. ☐ First, a comprehensive study of the ZnSe1-xOx compound prepared by reactive sputtering was completed. As the oxygen content in the reactive sputtering gas increased, ZnSe1-xOx crystallinity and bandgap decreased. It’s observed that oxygen miscibility in ZnSe was low and a secondary phase formed when the O2 / (O2 + Ar) ratio in the sputtering gas exceeded 2%. Two approaches were proposed to optimize the band alignment between the CIGS and buffer layer. One method focused on the bandgap engineering of the absorber, the other focused on the band structure modification of the buffer. As a result, improved current of the solar cell was achieved although a carrier transport barrier at the junction interface still limited the device performance. ☐ Second, an investigation of Zn(S,O) buffer layers was completed. Zn(S,O) films were sputtered in Ar using a ZnO0.7S0.3 compound target. Zn(S,O) films had the composition close to the target with S / (S+O) ratio around 0.3. Zn(S,O) films showed the wurtzite structure with the bandgap about 3.2eV. The champion Cu(In,Ga)Se2 / Zn(S,O) cell had 12.5% efficiency and an (Ag,Cu)(In,Ga)Se2 / Zn(S,O) cell achieved 13.2% efficiency. Detailed device analysis was used to study the Cu(In,Ga)Se2 and (Ag,Cu)(In,Ga)Se2 absorbers, the influence of absorber surface treatments, the effects of device treatments, the sputtering damage and the Na concentration in the absorber. ☐ Finally alternative buffer layer development was applied to an innovative superstrate CIGS configuration. The superstrate structure has potential benefits of improved window layer properties, cost reduction, and the possibility to implement back reflector engineering techniques. The application of three buffer layer options – CdS, ZnO and ZnSe was studied and limitations of each were characterized. The best device achieved 8.6% efficiency with a ZnO buffer. GaxOy formation at the junction interface was the main limiting factor of this device performance. For CdS / CIGS and ZnSe / CIGS superstrate devices extensive inter-diffusion between the absorber and buffer layer under CIGS growth conditions was the critical problem. Inter-diffusion severely deteriorated the junction quality and led to poorly behaved devices, despite different efforts to optimize the fabrication process.University of Delaware, Department of Materials Science and EngineeringPh.D

Exploring tunneling time by instantaneous ionization rate in strong-field ionization

A quantum approach is presented to investigate tunneling time by supervising the instantaneous ionization rate. We find that the ionization rate peak appearance lags behind the maximum of electric field intensity for a linearly polarized pulse. This time delay interval can be taken to characterize the tunneling time. In addition, if an atom with anisotropic electronic distribution is exposed to a circular polarized pulse, the tunneling time can also be measured and defined as the time difference between the instant of the largest ionization rate and the moment when the electric field points in the maximum of the bound electron density. (C) 2017 Optical Society of Americ

Investigating tunneling process of atom exposed in circularly polarized strong-laser field

We propose a method for studying the tunneling process by analyzing the instantaneous ionization rate of a circularly polarized laser. A numerical calculation shows that, for an atom exposed to a long laser pulse, if its initial electronic state wave function is non-spherical symmetric, the delayed phase shift of the ionization rate vs the laser cycle period in real time in the region close to the peak intensity of the laser pulse can be used to probe the tunneling time. In this region, an obvious time delay phase shift of more than 190 attoseconds is observed. Further study shows that the atom has a longer tunneling time in the ionization under a shorter wavelength laser pulse. In our method, a Wigner rotation technique is employed to numerically solve the time-dependent Schrodinger equation of a single-active electron in a three-dimensional spherical coordinate system

CEO interview on CNBC and post earnings announcement drift.

This paper investigates whether media attention specifically in the form of CEO interviews affects abnormal returns and hence post earnings announcement drift (PEAD). We look at 222 samples of CEO interview and no CEO interview group. We observe a significant positive average cumulative abnormal return of 106 bps in the window of [-2, -1] relative to earnings announcement day when positive earnings surprise occurs for samples with CEO interviews.BUSINES

Urban Land Intensive Use Evaluation Study Based on Nighttime Light—A Case Study of the Yangtze River Economic Belt

Urban land intensive use meets the requirements for the sustainable development of urban land and is an important part of urban sustainable development. The Yangtze River Economic Belt (YREB) spans the three major regions of China, which are the most active areas of China’s economy. The contradiction between humans and land is becoming more acute. There are also regional differences in land use patterns affecting the coordinated development of the YREB and the construction of an ecological civilization. Therefore, the scientific evaluation of urban land intensive use is a key area in the current research field of urban sustainable development. In this study, the YREB is chosen as the research object, and urban land intensive use is studied using nighttime light data and statistical data on the urban built-up area. An evaluation model based on urban nighttime light intensity and land urbanization is constructed with an allometric growth model. Considering that the impact of land urbanization on urban nighttime light has a possible lag effect, an evaluation model of land intensive use that considers the lag effect between urban nighttime light and the land urbanization level is proposed. Using urban agglomerations and some typical cities in the study area as research samples, the characteristics of urban nighttime light and land urbanization are analyzed to reveal the spatial and temporal characteristics of land development in the YREB. The results show that nighttime light remote-sensing data can better reflect the level of urban land use, the allometric growth model can better fit the intensity of urban light and the land urbanization level, and the allometric growth characteristics can reflect the land use characteristics of different cities and urban agglomerations. In regional experiments with typical cities and with urban agglomerations, compared to the original allometric growth model, the goodness of fit of the allometric growth model with the lag effect improves, on average, by 3.2% and 2%, respectively, with the highest increases being by 9.9% and 4.9%, respectively. The level of intensive land use in the YREB gradually decreases from east to west, and there are great differences among different cities in the provinces and urban agglomerations. The lower reaches of the Yangtze River have high land intensive use on the whole. In the middle reaches, multicenter cities have a greater efficiency of land use than the surrounding cities. In the upper reaches, only Chengdu and Chongqing have clear advantages in urban land intensive use. The results of this study can be helpful in providing an important reference for the sustainable development of land in the YREB and can provide a basis for future urban land optimization and sustainable development. Realizing the coordination and linkage between key cities and major cities is the key to enhancing the overall sustainable development ability of the core cities in the YREB