Difusión digital del patrimonio arquitectónico aragonés

El objetivo del proyecto es el desarrollo de un plan de difusión del patrimonio arquitectónico aragonés (edificio o conjunto de edificios), haciendo hincapié en las estrategias gráficas orientadas a los medios digitales, incluyendo levantamientos arquitectónicos, infografías, modelos interactivos, etc. Se va a realizar una búsqueda de información en biblioteca (distinta bibliografía asociada al proyecto) y en soporte digital (webs, blogs, revistas digitales, etc.) que complemente esa información. En el levantamiento digital del objeto de interés se emplearán software de dibujo vectorial, para los resultados en dos dimensiones, y software otogramétrico, para los resultados en tres dimensiones. Para el desarrollo del trabajo se pretende realizar un análisis del elemento del patrimonio arquitectónico aragonés, realizar un levantamiento arquitectónico y establecer un sistema digital que permita la difusión de esa información. La elaboración del trabajo se plantea en seis fases: - Descripción del objeto arquitectónico de estudio (contexto, historia, etc.) - Descripción de levantamiento arquitectónico - Descripción de las distintas herramientas digitales aplicadas. - Descripción del uso de las herramientas digitales aplicadas. - Elaboración de un sistema de difusión de la información. - Conclusiones

A linked data approach to sentiment and emotion analysis of twitter in the financial domain

Sentiment analysis has recently gained popularity in the financial domain thanks to its capability to predict the stock market based on the wisdom of the crowds. Nevertheless, current sentiment indicators are still silos that cannot be combined to get better insight about the mood of different communities. In this article we propose a Linked Data approach for modelling sentiment and emotions about financial entities. We aim at integrating sentiment information from different communities or providers, and complements existing initiatives such as FIBO. The ap- proach has been validated in the semantic annotation of tweets of several stocks in the Spanish stock market, including its sentiment information

Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain

BACKGROUND: We have previously described the identification and characterization of polyserase-1 and polyserase-2, two human serine proteases containing three different catalytic domains within the same polypeptide chain. Polyserase-1 shows a complex organization and it is synthesized as a membrane-bound protein which can generate three independent serine protease domains as a consequence of post-translational processing events. The two first domains are enzymatically active. By contrast, polyserase-2 is an extracellular glycosylated protein whose three protease domains remain embedded in the same chain, and only the first domain possesses catalytic activity. RESULTS: Following our interest in the study of the human degradome, we have cloned a human liver cDNA encoding polyserase-3, a new protease with tandem serine protease domains in the same polypeptide chain. Comparative analysis of polyserase-3 with the two human polyserases described to date, revealed that this novel polyprotein is more closely related to polyserase-2 than to polyserase-1. Thus, polyserase-3 is a secreted protein such as polyserase-2, but lacks additional domains like the type II transmembrane motif and the low-density lipoprotein receptor module present in the membrane-anchored polyserase-1. Moreover, analysis of post-translational mechanisms operating in polyserase-3 maturation showed that its two protease domains remain as integral parts of the same polypeptide chain. This situation is similar to that observed in polyserase-2, but distinct from polyserase-1 whose protease domains are proteolytically released from the original chain to generate independent units. Immunolocalization studies indicated that polyserase-3 is secreted as a non-glycosylated protein, thus being also distinct from polyserase-2, which is a heavily glycosylated protein. Enzymatic assays indicated that recombinant polyserase-3 degrades the α-chain of fibrinogen as well as pro-urokinase-type plasminogen activator (pro-uPA). Northern blot analysis showed that polyserase-3 exhibits a unique expression pattern among human polyserases, being predominantly detected in testis, liver, heart and ovary, as well as in several tumor cell lines. CONCLUSION: These findings contribute to define the growing group of human polyserine proteases composed at present by three different proteins. All of them share a complex structural design with several catalytic units in a single polypeptide but also show specific features in terms of enzymatic properties, expression patterns and post-translational maturation mechanisms

La relación entre el grado de centralización de la negociación colectiva y la tasa de desempleo : nuevos resultados

Artículo de revist

Fatigue in multiple sclerosis: general and perceived fatigue does not depend on corticospinal tract dysfunction.

Background: Multiple sclerosis (MS) is an autoimmune disorder of the CNS in which inflammation, demyelination, and axonal damage of the central nervous system coexist. Fatigue is one of the most disabling symptoms in MS and little is known about the neurophysiological mechanisms involved. Methods: To give more mechanistic insight of fatigue in MS, we studied a cohort of 17 MS patients and a group of 16 age-matched healthy controls. Baseline Fatigue Severity Scales and Fatigue Rating were obtained from both groups to check the level of fatigue and to perform statistical correlations with fatigue-induced neurophysiologic changes. To induce fatigue we used a handgrip task. During the fatiguing task, we evaluated fatigue state (using a dynamometer) and after the task we evaluated the Borg Rating of Perceived Exertion Scale. Transcranial magnetic stimulation and peripheral electric stimulation were used to assess corticospinal tract and peripheral system functions before and after the task. Results: Clinically significant fatigue and central motor conduction time were greater in patients than in controls, while motor cortex excitability was decreased and maximal handgrip strength reduced in patients. Interestingly, fatigue state was positively correlated to perceived fatigue in controls but not in patients. Furthermore, in the presence of similar fatigue state over time, controls showed a significant fatigue-related reduction in motor evoked potential (a putative marker of central fatigue) whereas this effect was not seen in patients. Conclusions: in MS patients the pathogenesis of fatigue seems not driven by the mechanisms directly related to corticospinal function (that characterize fatigue in controls) but seems probably due to other “central abnormalities” upstream to primary motor cortex.post-print1473 K

Labour mobility in the EU: Dynamics, patterns and policies

The continued economic crisis has become a major test for the labour markets of individual member states. Labour mobility within the European Union has the potential to help to reduce labour market pressures and ease economic imbalances. However, a long-term loss of working age population can be detrimental to sending countries. This Forum explores mobility patterns within the European Union and analyses the labour market and welfare effects of labour mobility via case studies of the UK, Poland, Germany and Spain. It also examines a number of its aspects that have important political and institutional relevance for the European Union and its future

Comprehensive Analysis of SWI/SNF Inactivation in Lung Adenocarcinoma Cell Models

Simple Summary: Mammalian SWI/SNF complexes regulate gene expression by reorganizing the way DNA is packaged into chromatin. SWI/SNF subunits are recurrently altered in tumors at multiple levels, including DNA mutations as well as alteration of the levels of RNA and protein. Cancer cell lines are often used to study SWI/SNF function, but their patterns of SWI/SNF alterations can be complex. Here, we present a comprehensive characterization of DNA mutations and RNA and protein expression of SWI/SNF members in 38 lung adenocarcinoma (LUAD) cell lines. We show that over 85% of our cell lines harbored at least one alteration in one SWI/SNF subunit. In addition, over 75% of our cell lines lacked expression of at least one SWI/SNF subunit at the protein level. Our catalog will help researchers choose an appropriate cell line model to study SWI/SNF function in LUAD. Abstract: Mammalian SWI/SNF (SWitch/Sucrose Non-Fermentable) complexes are ATP-dependent chromatin remodelers whose subunits have emerged among the most frequently mutated genes in cancer. Studying SWI/SNF function in cancer cell line models has unveiled vulnerabilities in SWI/SNF-mutant tumors that can lead to the discovery of new therapeutic drugs. However, choosing an appropriate cancer cell line model for SWI/SNF functional studies can be challenging because SWI/SNF subunits are frequently altered in cancer by various mechanisms, including genetic alterations and post-transcriptional mechanisms. In this work, we combined genomic, transcriptomic, and proteomic approaches to study the mutational status and the expression levels of the SWI/SNF subunits in a panel of 38 lung adenocarcinoma (LUAD) cell lines. We found that the SWI/SNF complex was mutated in more than 76% of our LUAD cell lines and there was a high variability in the expression of the di erent SWI/SNF subunits. These results underline the importance of the SWI/SNF complex as a tumor suppressor in LUAD and the di culties in defining altered and unaltered cell models for the SWI/SNF complex. These findings will assist researchers in choosing the most suitable cellular models for their studies of SWI/SNF to bring all of its potential to the development of novel therapeutic applications.Ministry of Economy of Spain SAF2015-67919-RJunta de Andalucía CS2016-3 P12-BIO1655 PIGE-0440-2019 Pl-0245-2017 PI-0135-2020University of Granada PPJIA2019-0 B-CTS-126-UGR18International Association for the Study of Lung Cancer (IASLC)Spanish Association for Cancer Research (LAB-AECC)PhD "La Caixa Foundation" LCF/BQ/DE15/10360019"Fundacion Benefica Anticancer Santa Candida y San Francisco Javier" predoctoral fellowshipEuropean Commission 837897Spanish Ministry of Education, Culture and Sports FPU fellowship FPU17/00067 FPU17/01258 FPU18/03709PhD FPI-fellowship BES-2013-064596Fundación Científica de la Asociación Española Contra el Cáncer GCB14-2170Fundación Ramon ArecesInstituto de Salud Carlos III-Fondo de Investigación Sanitaria-Fondo Europeo de Desarrollo Regional `Una manera de hacer Europa' (FEDER) PI19/0009

Estudios preliminares de la perla de la vid Margarodes vitis (hemiptera: margarodidae) en viñedos de La Consulta, Mendoza, Argentina

La perla de la vid, Margarodes vitis (Philippi), es un insecto subterráneo que se alimenta de las raíces de Vitis vinifera. Los daños se manifiestan como un decaimiento progresivo causando la muerte de la planta. El estudio de la distribución espacial de los insectos brinda información fundamental para implementar programas de Manejo Integrado de Plagas. El objetivo del trabajo fue determinar el ciclo de vida, la relación síntomas en las plantas-número de insectos/kg suelo y la distribución espacial del insecto. Se realizaron muestreos quincenales en La Consulta, Mendoza desde setiembre de 2012 a marzo de 2013. Las muestras se procesaron en laboratorio registrándose el número de quistes/1000 g de suelo. Se observaron hembras y huevos, pero no ninfas de primer estadio, desde fines de noviembre hasta principios de enero. Se usaron varios índices de dispersión. También se estimaron los coeficientes a y b de la Ley Potencial de Taylor y α y β de la Regresión de Iwao. M. vitis siempre presentó una distribución agregada. El análisis del coeficiente de correlación de Spearman mostró una relación significativa (P<0,0001) entre el número de quistes y la escala de daños. Esta información permitirá desarrollar planes de muestreo y estrategias de control.The ground pearl, Margarodes vitis (Philippi), is a subterranean sucking plant insect that feeds on the roots of Vitis vinifera. Damages are shown as a progressive decline, causing the death of the plant. Study of insect spatial patterns provides critical information to implement an Integrated Pest Management program. The aim of this study was to determine the lifecycle, symptoms related plants insect-number / kg soil and spatial pattern of the insect. Twice a month samplings were carried out, between September 2012 to March 2013 in La Consulta, Mendoza.The samples were processed in laboratory and the number of cysts / 1000 g soil was registered. Females and eggs, but not first instar nymphs were observed from late November to early January. Several dispersion indexes were applied .The a and b coefficients of Taylor’s Power Law and α and β of the Iwao´s Regression coefficients were also estimated. Always, M. vitis showed an aggregate pattern. An analysis of Spearman´s correlation coefficient showed that significant differences (P< 0.0001) occurred between number of cysts and damage scale. This information is useful to develop sampling plans and control strategies.Inst. de Microbiología y Zoología Agrícola IMyZAFil: Gonzalez, M.F. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Microbiología y Zoología Agrícola; ArgentinaFil: Casciani, Juan Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; ArgentinaFil: Pareja Perdomo, Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; ArgentinaFil: Prior, C. IES N.° 9-015 Valle de Uco; ArgentinaUCOFil: Peinado Manzur, Horacio Hernan. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentin

Desarrollo de modelos 3D de los edificios de contención de la Central Nuclear de Almaraz y de la Central Nuclear de Trillo con el código GOTHIC 8.0

El análisis de los accidentes tipo LOCA o MSLB en una contención PWR-W normalmente se simulan con la opción de volúmenes de control con parámetros agrupados en GOTHIC, ya que es lo que hasta ahora se ha considerado adecuado para el análisis de licencia. Sin embargo, para el estudio de detalle del comportamiento termo-hidráulico de cada recinto de la contención, podría ser más adecuado contar con un modelo tridimensional que representase más fielmente la geometría de la contención. El objetivo de la primera fase del proyecto de investigación de CNAT y la UPM es la construcción de varios modelos tridimensionales detallados con el código GOTHIC 8.0 de los edificios de contención de una planta tipo PWR-W y KWU, correspondientes a la Central Nuclear de Almaraz (CNA) y Trillo (CNT) respectivamente

Patrimonio natural antropizado del area minera de Río Tinto (España)

España Ministerio de Educación y Ciencia CGL2008-06270-C y CTM2005-05832 .España Junta de Andalucía P09-RNM-516