Morphology-related foot function analysis:implications for jumping and running

Barefoot and shod running has received increased attention in recent years, however, the influence of morphology-related foot function has not been explored. This study aimed to investigate morphology-related jumping and running biomechanical functions in habitually barefoot and shod males. A total of 90 barefoot males (Indians) and 130 shod males (Chinese), with significant forefoot and toe morphology differences, participated in a vertical jump and running test to enable the collection of kinematic and kinetic data. The difference of pressure distribution in the hallux and forefoot was shown while jumping and running. The unrestricted forefoot and toes of the barefoot group presented flexible movement and leverage functions to expand the forefoot loading area during performance of the two tasks. Findings related to morphology functions, especially in the forefoot and toe may provide useful information for footwear design

The mechanism of palmatine-mediated intestinal flora and host metabolism intervention in OA-OP comorbidity rats

BackgroundErXian decoction is a Chinese herbal compound that can prevent and control the course of osteoarthritis (OA) and osteoporosis (OP). OP and OA are two age-related diseases that often coexist in elderly individuals, and both are associated with dysregulation of the gut microbiome. In the initial study, Palmatine (PAL) was obtained by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and network pharmacological screening techniques, followed by 16S rRNA sequencing and serum metabolomics of intestinal contents, to explore the mechanism of PAL in the treatment of OA and OP.MethodsThe rats selected for this study were randomly divided into three groups: a sham group, an OA-OP group and a PAL group. The sham group was intragastrically administered normal saline solution, and the PLA group was treated with PAL for 56 days. Through microcomputed tomography (micro-CT), ELISA, 16S rRNA gene sequencing and non-targeted metabonomics research, we explored the potential mechanism of intestinal microbiota and serum metabolites in PAL treatment of OA-OP rats.ResultsPalmatine significantly repair bone microarchitecture of rat femur in OA-OP rats and improved cartilage damage. The analysis of intestinal microflora showed that PAL could also improve the intestinal microflora disorder of OA-OP rats. For example, the abundance of Firmicutes, Bacteroidota, Actinobacteria, Lactobacillus, unclassified_f_Lachnospiraceae, norank_f_Muribaculaceae, Lactobacillaceae, Lachnospiraceae and Muribaculaceae increased after PAL intervention. In addition, the results of metabolomics data analysis showed that PAL also change the metabolic status of OA-OP rats. After PAL intervention, metabolites such as 5-methoxytryptophol, 2-methoxy acetaminophen sulfate, beta-tyrosine, indole-3-carboxylic acid-O-sulfate and cyclodopa glucoside increased. Association analysis of metabolomics and gut microbiota (GM) showed that the communication of multiple flora and different metabolites played an important role in OP and OA.ConclusionPalmatine can improve cartilage degeneration and bone loss in OA-OP rats. The evidence we provided supports the idea that PAL improves OA-OP by altering GM and serum metabolites. In addition, the application of GM and serum metabolomics correlation analysis provides a new strategy for uncovering the mechanism of herbal treatment for bone diseases

The Acute Influence of Running-Induced Fatigue on the Performance and Biomechanics of a Countermovement Jump

Lower limb kinematics and kinetics during the landing phase of jumping might change because of localized muscle fatigue. This study aimed to investigate the acute influence of running-induced fatigue on the performance and lower limb kinematics and kinetics of a countermovement jump. A running-induced fatigue protocol was applied to fifteen male subjects. Participants were asked to perform three successful countermovement jumps before and after fatigue. Kinematic and kinetic data were collected to compare any fatigue influences. Wilcoxon signed-rank tests and paired-sample t-tests were used to analyze the data. Running-induced fatigue did not significantly change vertical jump height and peak vertical ground reaction forces (GRF) during the push-off and landing phases. Lower limb biomechanics significantly changed, especially kinematic parameters. During the push-off phase, fatigue resulted in an increased ankle peak inversion angle, knee minimal flexion angle, knee peak abduction angle, and hip peak flexion moment. In addition, the range of motion (ROM) of the ankle and knee joints in the frontal plane was also increased. Certain parameters decreased as a result of fatigue, such as the ankle peak internal rotation angle, hip peak abduction angle, the ROM of the ankle joint in the sagittal plane, and ROM of the hip joint in the frontal plane. During the landing phase, the peak inversion angle and peak external rotation angle of the ankle joint, peak abduction angle of the knee and hip joint, ROM of the ankle joint in the horizontal plane, ROM of the ankle and knee joint in the frontal plane were all increased as a result of fatigue. The knee peak flexion moment and hip peak extension moment, however, were decreased. Under fatigue conditions, lower limb kinetics and kinematics were changed during both the push-off and landing phases. More attention should be focused on the landing phase and the last period of the push-off phase due to potentially higher risks of injury. The findings of the current study may be beneficial to athletes and coaches in preventing jumping related injuries

Locomotion Variations of Arch Index and Interlimb Symmetry in Shod and Barefoot Populations

The purpose of this study was to investigate the variations of arch index from static standing to dynamic walking and running; furthermore, the interlimb symmetry was checked in the two populations. A total of eighty male participants were recruited for this study, with forty habitually barefoot and forty habitually shod males, respectively. Arch index (AI) was calculated following the previously established “gold standard” measurement via contact areas recorded from EMED. Repeated measure analysis of variance (ANOVA) was employed to compare the difference between static and dynamic walking and running arch index. Paired-samples t-test and symmetry index (SI) were used to investigate the symmetry of the left foot arch index and right foot arch index. It was found that the dynamic arch index was significantly higher than the static arch index in barefoot and shod males, showing an increase from static weight-bearing standing to dynamic walking and running. However, interlimb (right-left) symmetry in the foot arch index was observed in the two populations. Dynamic changes of the arch index may provide implications that need to be considered while designing shoe lasts or insoles. Knowledge of the healthy arch index range reported from this study could also be used as a standard baseline to probe into foot and arch disorders

How to Improve the Standing Long Jump Performance? A Mininarrative Review

Standing long jump (SLJ) is complicated by the challenge of motor coordination in both the upper and lower segments. This movement is also considered to be a fundamental skill in a variety of sports. In particular, SLJ is an important test index for middle school students for assessing their physical fitness levels. This assessment takes the form of a physical fitness test high school entrance examination in some countries such as China. This minireview summarizes recent studies that have investigated how to improve the standing long jump performance from different aspects which include arm motion, takeoff angle, standing posture, warming-up exercise, and handheld weight. The common study limitations, controversial knowledge, and future research direction are also discussed in detail

Strengths, Microstructure and Nanomechanical Properties of Concrete Containing High Volume of Zeolite Powder

In order to save resources and reduce the carbon footprint of concrete, the addition of high volumes of supplementary cementitious materials (SCMs) to replace cement is one of the most effective and promising methods. Zeolite powder (ZP), with a high specific surface area, exhibits high pozzolanic reactivity in cement-based materials. This paper investigates the effects of ZP addition used to replace cement at the levels of 20%, 40% and 60% on the strength development and microstructure evolution of concrete, and the nanomechanical properties are analyzed using nanoindentation technique. The results show that the replacement of ZP for cement generally has a dilution effect on the concrete, leading to a detrimental effect on the strength development. However, the 20% ZP replacement for cement slightly enhances the 90-day compressive strength. The pore structure analysis shows that the sample with 20% ZP content has a lower total porosity than the control sample. The hydration of ZP goes against the dilution effect and reduces the total porosity of concrete to compact the microstructure. Nanoindentation investigation of the matrix shows that 20% ZP decreases the content of portlandite but increases the content of high density calcium silicate hydrate (C-S-H). This is beneficial for improving the nanomechanical properties of interface transition zone. However, further increases in the content of ZP (40% and 60%) decrease the total volume of C-S-H and increase the porosity to degrade the microstructure

The clinical features of familial focal epilepsy with variable foci and NPRL3 gene variant

Objective Familial focal epilepsy with variable foci (FFEVF) is a rare type of focal epilepsy syndrome; it is associated with NPRL3 variant. However, relevant reports are rare in China. We aimed to analyze the clinical features of Chinese patients with FFEVF to understand further the differences between various NPRL3 variants and explored the effect of NPRL3 variant on mRNA. Methods We ran a full workup on a family with FFEVF (four patients, one healthy member): an inquiry of medical history, cranial magnetic resonance imaging (MRI), electroencephalogram (EEG), and whole exon sequencing. Their clinical features were compared with those of other FFEVF patients in published reports. The mRNA splicing changes were analyzed quantitatively and qualitatively using real-time quantitative—polymerase chain reaction (q-PCR) and reverse transcription (RT)-PCR and compared between our patients and healthy individuals. Results Patients with NPRL3: c.1137dupT variant had a wide range of onset age (4 months to 31 years), diverse seizure types, variable foci (frontal lobe/temporal lobe), different seizure times (day/night) and frequencies (monthly/seldom/every day), different therapeutic effects (refractory epilepsy/almost seizure free), normal MRI, and abnormal EEG (epileptiform discharge, slow wave). The phenotypic spectrum with different NPRL3 variants was either similar or different. Significantly different relative quantities of mRNA were found between patients and healthy individuals in real-time qPCR. Abnormal splicing was observed in patients compared with healthy individual in RT-PCR. Despite having the same gene variant, different family members had different mRNA splicing, possibly causing different phenotypes. Conclusion The clinical features of FFEVF varied, and auxiliary inspection was atypical. NPRL3: c.1137dupT could change the relative quantity of mRNA and cause abnormal splicing, which might produce different phenotypes in different family members

The clinical features of familial focal epilepsy with variable foci and NPRL3 gene variant.

ObjectiveFamilial focal epilepsy with variable foci (FFEVF) is a rare type of focal epilepsy syndrome; it is associated with NPRL3 variant. However, relevant reports are rare in China. We aimed to analyze the clinical features of Chinese patients with FFEVF to understand further the differences between various NPRL3 variants and explored the effect of NPRL3 variant on mRNA.MethodsWe ran a full workup on a family with FFEVF (four patients, one healthy member): an inquiry of medical history, cranial magnetic resonance imaging (MRI), electroencephalogram (EEG), and whole exon sequencing. Their clinical features were compared with those of other FFEVF patients in published reports. The mRNA splicing changes were analyzed quantitatively and qualitatively using real-time quantitative-polymerase chain reaction (q-PCR) and reverse transcription (RT)-PCR and compared between our patients and healthy individuals.ResultsPatients with NPRL3: c.1137dupT variant had a wide range of onset age (4 months to 31 years), diverse seizure types, variable foci (frontal lobe/temporal lobe), different seizure times (day/night) and frequencies (monthly/seldom/every day), different therapeutic effects (refractory epilepsy/almost seizure free), normal MRI, and abnormal EEG (epileptiform discharge, slow wave). The phenotypic spectrum with different NPRL3 variants was either similar or different. Significantly different relative quantities of mRNA were found between patients and healthy individuals in real-time qPCR. Abnormal splicing was observed in patients compared with healthy individual in RT-PCR. Despite having the same gene variant, different family members had different mRNA splicing, possibly causing different phenotypes.ConclusionThe clinical features of FFEVF varied, and auxiliary inspection was atypical. NPRL3: c.1137dupT could change the relative quantity of mRNA and cause abnormal splicing, which might produce different phenotypes in different family members