Penta­aqua­(1H-benzimidazole-5,6-dicarboxyl­ato-κN 3)nickel(II) penta­hydrate

In the title mononuclear complex, [Ni(C9H4N2O4)(H2O)5]·5H2O, the NiII atom is six-coordinated by one N atom from a 1H-benzimidazole-5,6-dicarboxyl­ate ligand and by five O atoms from five water mol­ecules and displays a distorted octa­hedral geometry. Inter­molecular O—H⋯O hydrogen-bonding inter­actions among the coordinated water mol­ecules, solvent water mol­ecules and carboxyl O atoms of the organic ligand and additional N—H⋯O hydrogen bonding lead to the formation of a three-dimensional supra­molecular network

Diaqua­bis­(4-carb­oxy-2-propyl-1H-imidazole-5-carboxyl­ato-κ2 N 3,O 4)cobalt(II) N,N-dimethyl­formamide disolvate

In the title complex, [Co(C8H9N2O4)2(H2O)2]·2C3H7NO, the CoII cation (site symmetry ) is six-coordinated by two 5-carb­oxy-2-propyl-1H-imidazole-4-carboxyl­ate ligands and two water mol­ecules in a distorted octa­hedral environment. In the crystal structure, the complex mol­ecules and dimethyl­formamide solvent mol­ecules are linked by extensive O—H⋯O and N—H⋯O hydrogen bonding into sheets lying parallel to (21)

Hexaaqua­nickel(II) 4,4′-(1,2-dihy­droxy­ethane-1,2-di­yl)dibenzoate monohydrate

In the title compound, [Ni(H2O)6](C16H12O6)·H2O, the NiII cation is located on a mirror plane and is coordinated by six water mol­ecules, two of which are also located on the mirror plane, in a distorted octa­hedral geometry. The 4,4′-(1,2-dihy­droxy­ethane-1,2-di­yl)dibenzoate anion is centrosymmetric with the mid-point of the central ethane C—C bond located on an inversion center. The uncoordinated water mol­ecule is located on a mirror plane. Extensive O—H⋯O hydrogen bonding is present in the crystal structure

Poly[(μ4-tetra­zole-1-acetato-κ4 N 3:N 4:O:O′)silver(I)]

In the title complex, [Ag(C3H3N4O2)]n, the AgI atom is four-coordinated in a slightly distorted tetra­hedral coordination geometry by two N atoms from two tetra­zole-1-acetate (tza) ligands and two O atoms from the other two tza ligands. The tza ligand bridges two Ag atoms through the carboxyl­ate O atoms and simultaneously binds to the other two Ag atoms through the tetra­zole N atoms, forming a two-dimensional network parallel to (100)

Analysis of intravitreal injection of triamcinolone acetonide before vitrectomy for retinal detachment associated with choroidal detachment

AIM:To observe the clinical effects of intravitreal injection of triamcinolone acetonide(TA)before vitrectomy for retinal detachment associated with choroidal detachment.METHODS: Totally 23 cases(23 eyes)of retinal detachment associated with choroidal detachment in our hospital were treated by intravitreal injection of TA 4-5d before 23-Gauge micro-invasive vitrectomy combined with silicone oil injection. All the cases were followed up between 6 to 9mo. The anatomic retinal reattachment, visual acuity, intraocular pressure and postoperative complications were observed and analyzed. RESULTS: After the surgery, the visual acuity of all patients were improved, with 9 eyes better than 0.3(39%), and 18 eyes better than 0.05(78%). The BCVA at 1wk, 1 and 3mo and last follow up were different compared with before operations(PPPCONCLUSION: Intravitreal injection of TA before vitrectomy for retinal detachment associated with choroidal could improve the clinical effects, and decrease the difficulty of surgery while the injection itself is pretty safe

Penta­aqua­(1H-benzimidazole-5,6-di­carboxyl­ato-κN 3)cobalt(II) penta­hydrate

In the title mononuclear complex, [Co(C9H4N2O4)(H2O)5]·5H2O, the CoII atom exhibits a distorted octa­hedral geometry involving an N atom of a 1H-benzimidazole-5,6-dicarboxyl­ate ligand and five water O atoms. A supra­molecular network is generated through inter­molecular O—H⋯O hydrogen-bonding inter­actions involving the coordinated and uncoordinated water mol­ecules and the carboxyl O atoms of the organic ligand. An inter­molecular N—H⋯O hydrogen bond is also observed

Poly[diaqua-μ2-isonicotinato-μ2-oxalato-terbium(III)]

In the crystal structure of the title complex, [Tb(C6H4NO2)(C2O4)(H2O)2]n, the TbIII cation is coordinated by four O atoms from two oxalate ligands, two O atoms from two isonicotinate ligands and two O atoms from water mol­ecules within a distorted square–anti­prismatic coordination. The TbIII cation, the isonicotinate anion and the two crystallographically independent water mol­ecules occupy general positions, whereas one of the two crystallographically independent oxalate anions is located on a center of inversion, and the second oxalate anion is located on a twofold rotation axis. The TbIII cations are linked by the oxalate and isonicotinate anions into layers, which are connected via inter­molecular hydrogen-bonding and π–π stacking [with centroid-to-centroid distances of 3.509 (2) and 3.343 (3) Å] inter­actions into a three-dimensional network

catena-Poly[[diaqua­(1,10-phenanthroline-κ2 N,N′)nickel(II)]-μ-1H-benzimidazole-5,6-dicarboxyl­ato-κ2 N 3:O 6]

In the title complex, [Ni(C9H4N2O4)(C12H8N2)(H2O)2]n, the NiII atom is hexa­coordinated by one N and one O atom from two different 1H-benzimidazole-5,6-dicarboxyl­ate ligands, two N atoms from one 1,10-phenanthroline ligand and two water mol­ecules. The flexible 1H-benzimidazole-5,6-dicarboxyl­ate ligands link the NiII centres, forming an infinite zigzag chain parallel to [001]. The crystal packing is governed by inter­molecular hydrogen-bonding inter­actions of the O—H⋯O, N—H⋯O and C—H⋯O types

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

SummarySterol regulatory element-binding proteins (SREBPs) are major transcription factors activating the expression of genes involved in biosynthesis of cholesterol, fatty acid and triglyceride. In this study, we identified a small molecule, betulin, that specifically inhibited the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig. Inhibition of SREBP by betulin decreased the biosynthesis of cholesterol and fatty acid. In vivo, betulin ameliorated diet-induced obesity, decreased the lipid contents in serum and tissues, and increased insulin sensitivity. Furthermore, betulin reduced the size and improved the stability of atherosclerotic plaques. Our study demonstrates that inhibition SREBP pathway can be employed as a therapeutic strategy to treat metabolic diseases including type II diabetes and atherosclerosis. Betulin, which is abundant in birch bark, could be a leading compound for development of drugs for hyperlipidemia