30 research outputs found
Transformer Convolutional Neural Networks for Automated Artifact Detection in Scalp EEG
It is well known that electroencephalograms (EEGs) often contain artifacts
due to muscle activity, eye blinks, and various other causes. Detecting such
artifacts is an essential first step toward a correct interpretation of EEGs.
Although much effort has been devoted to semi-automated and automated artifact
detection in EEG, the problem of artifact detection remains challenging. In
this paper, we propose a convolutional neural network (CNN) enhanced by
transformers using belief matching (BM) loss for automated detection of five
types of artifacts: chewing, electrode pop, eye movement, muscle, and shiver.
Specifically, we apply these five detectors at individual EEG channels to
distinguish artifacts from background EEG. Next, for each of these five types
of artifacts, we combine the output of these channel-wise detectors to detect
artifacts in multi-channel EEG segments. These segment-level classifiers can
detect specific artifacts with a balanced accuracy (BAC) of 0.947, 0.735,
0.826, 0.857, and 0.655 for chewing, electrode pop, eye movement, muscle, and
shiver artifacts, respectively. Finally, we combine the outputs of the five
segment-level detectors to perform a combined binary classification (any
artifact vs. background). The resulting detector achieves a sensitivity (SEN)
of 60.4%, 51.8%, and 35.5%, at a specificity (SPE) of 95%, 97%, and 99%,
respectively. This artifact detection module can reject artifact segments while
only removing a small fraction of the background EEG, leading to a cleaner EEG
for further analysis.Comment: This is an extension to a paper presented at the 2022 44th Annual
International Conference of the IEEE Engineering in Medicine & Biology
Society (EMBC) Scottish Event Campus, Glasgow, UK, July 11-15, 202
Multi-center validation study of automated classification of pathological slowing in adult scalp electroencephalograms via frequency features
Pathological slowing in the electroencephalogram (EEG) is widely investigated
for the diagnosis of neurological disorders. Currently, the gold standard for
slowing detection is the visual inspection of the EEG by experts, which is
time-consuming and subjective. To address those issues, we propose three
automated approaches to detect slowing in EEG: Threshold-based Detecting System
(TDS), Shallow Learning-based Detecting System (SLDS), and Deep Learning-based
Detecting System (DLDS). These systems are evaluated on channel-, segment- and
EEG-level. The TDS, SLDS, and DLDS performs prediction via detecting slowing at
individual channels, and those detections are arranged in histograms for
detection of slowing at the segment- and EEG-level. We evaluate the systems
through Leave-One-Subject-Out (LOSO) cross-validation (CV) and
Leave-One-Institution-Out (LOIO) CV on four datasets from the US, Singapore,
and India. The DLDS achieved the best overall results: LOIO CV mean balanced
accuracy (BAC) of 71.9%, 75.5%, and 82.0% at channel-, segment- and EEG-level,
and LOSO CV mean BAC of 73.6%, 77.2%, and 81.8% at channel-, segment-, and
EEG-level. The channel- and segment-level performance is comparable to the
intra-rater agreement (IRA) of an expert of 72.4% and 82%. The DLDS can process
a 30-minutes EEG in 4 seconds and can be deployed to assist clinicians in
interpreting EEGs.Comment: 24 pages. For submission to International Journal of Neural Systems
(IJNS
Investigation of Riemann hypothesis via Rényi dimension and Hurst exponent
The Riemann hypothesis is an unsolved problem in mathematics involving the
locations of the non-trivial zeros in the Riemann zeta function, and state that:
"The real part of every non-trivial zero of the Riemann zeta function is 1/2."
This means all non-trivial zeros must lie along a critical line composes of complex
numbers with Re(s) = 1/2 .
The final year project assesses the possible application of the Rényi dimension and
Hurst exponent to study the Riemann zeta function and the Riemann hypothesis.
The results obtained from the algorithms when applied to the Riemann zeta
function along the critical line shows that the zeta function became more
fractured and anti-persistent along the critical line. This implies that these two
methods are able to yield correct results and thus is a feasible way to tackle the
Riemann hypothesis.Bachelor of Engineering (Aerospace Engineering
Deep learning methods for diagnosis of epilepsy from electroencephalograms
Brain diseases such as epilepsy, brain trauma, and stroke are serious neurological conditions and require treatments. These diseases can be diagnosed with an electroencephalogram (EEG), which can help review brain abnormalities such as excessive slowing or seizures. Hence, EEG is essential for neurological diagnosis. Unfortunately, reviewing an EEG is challenging, as EEG recordings can last for hours and be contaminated with artifacts. To automate the process, an automated EEG detector is necessary. In this study, we design three convolutional neural networks (CNN)-based pipelines to detect slowing, artifacts, and seizures in single-channel segment (channel-level), multi-channel segment (segment-level), and full EEG (EEG-level). First, we develop a CNN-based slowing detector to detect pathological slowing at the channel-, segment-, and EEG-level. Across four datasets, the detector reports a mean balanced accuracy (BAC) of 82.0% and 81.8% at the EEG-level for leave-one-institution-out (LOIO) and the leave-one-subject-out (LOSO) cross-validation (CV), respectively. Furthermore, the detector can process a 30-minute EEG in 4 seconds, allowing real-time deployments. Second, we design a CNN-transformer with a belief matching (BM) loss (CNN-TRF-BM) model to detect chewing, electrode pop, eye movement, muscle, and shiver artifacts at the channel- and segment-level. The artifact detector reports a sensitivity (SEN) of 0.420, 0.320, and 0.133, subject to a fixed specificity of 95%, 97%, and 99%, respectively. The artifact detector can identify and reject artifacts with high specificity, leading to a cleaner EEG for visual evaluations. Finally, we develop a patient-independent CNN-TRF-BM-based seizure detector to detect seizures at the channel-, segment-, and EEG-level. Across six datasets, the system achieves EEG-level seizure detection average sensitivity (SEN) of 0.227-1.00, average precision (PRE) of 0.377-1.00, and median false positive rate per hour (FPR/h) of 0-0.559. The seizure detector performs detection in less than 15 seconds for a 30-minute EEG and can accelerate the EEG reviewing process. In conclusion, the proposed slowing, artifact, and seizure detectors can tremendously boost the review of EEG in clinical practice.Doctor of Philosoph
Transformer Convolutional Neural Networks for Automated Artifact Detection in Scalp EEG
It is well known that electroencephalograms (EEGs) often contain artifacts due to muscle activity, eye blinks, and various other causes. Detecting such artifacts is an essential first step toward a correct interpretation of EEGs. Although much effort has been devoted to semi-automated and automated artifact detection in EEG, the problem of artifact detection remains challenging. In this paper, we propose a convolutional neural network (CNN) enhanced by transformers using belief matching (BM) loss for automated detection of five types of artifacts: chewing, electrode pop, eye movement, muscle, and shiver. Specifically, we apply these five detectors at individual EEG channels to distinguish artifacts from background EEG. Next, for each of these five types of artifacts, we combine the output of these channel-wise detectors to detect artifacts in multi-channel EEG segments. These segment-level classifiers can detect specific artifacts with a balanced accuracy (BAC) of 0.947, 0.735, 0.826, 0.857, and 0.655 for chewing, electrode pop, eye movement, muscle, and shiver artifacts, respectively. Finally, we combine the outputs of the five segment-level detectors to perform a combined binary classification (any artifact vs. background). The resulting detector achieves a sensitivity (SEN) of 42.0%, 32.0%, and 13.3%, at a specificity (SPE) of 95%, 97%, and 99%, respectively. This artifact detection module can reject artifact segments while only removing a small fraction of the background EEG, leading to a cleaner EEG for further analysis
Transformer Convolutional Neural Networks for Automated Artifact Detection in Scalp EEG
It is well known that electroencephalograms (EEGs) often contain artifacts due to muscle activity, eye blinks, and various other causes. Detecting such artifacts is an essential first step toward a correct interpretation of EEGs. Although much effort has been devoted to semi-automated and automated artifact detection in EEG, the problem of artifact detection remains challenging. In this paper, we propose a convolutional neural network (CNN) enhanced by transformers using belief matching (BM) loss for automated detection of five types of artifacts: chewing, electrode pop, eye movement, muscle, and shiver. Specifically, we apply these five detectors at individual EEG channels to distinguish artifacts from background EEG. Next, for each of these five types of artifacts, we combine the output of these channel-wise detectors to detect artifacts in multi-channel EEG segments. These segment-level classifiers can detect specific artifacts with a balanced accuracy (BAC) of 0.947, 0.735, 0.826, 0.857, and 0.655 for chewing, electrode pop, eye movement, muscle, and shiver artifacts, respectively. Finally, we combine the outputs of the five segment-level detectors to perform a combined binary classification (any artifact vs. background). The resulting detector achieves a sensitivity (SEN) of 42.0%, 32.0%, and 13.3%, at a specificity (SPE) of 95%, 97%, and 99%, respectively. This artifact detection module can reject artifact segments while only removing a small fraction of the background EEG, leading to a cleaner EEG for further analysis.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Signal Processing System
Six-Center Assessment of CNN-Transformer with Belief Matching Loss for Patient-Independent Seizure Detection in EEG
Neurologists typically identify epileptic seizures from electroencephalograms (EEGs) by visual inspection. This process is often time-consuming, especially for EEG recordings that last hours or days. To expedite the process, a reliable, automated, and patient-independent seizure detector is essential. However, developing a patient-independent seizure detector is challenging as seizures exhibit diverse characteristics across patients and recording devices. In this study, we propose a patient-independent seizure detector to automatically detect seizures in both scalp EEG and intracranial EEG (iEEG). First, we deploy a convolutional neural network with transformers and belief matching loss to detect seizures in single-channel EEG segments. Next, we extract regional features from the channel-level outputs to detect seizures in multi-channel EEG segments. At last, we apply post-processing filters to the segment-level outputs to determine seizures' start and end points in multi-channel EEGs. Finally, we introduce the minimum overlap evaluation scoring as an evaluation metric that accounts for minimum overlap between the detection and seizure, improving upon existing assessment metrics. We trained the seizure detector on the Temple University Hospital Seizure (TUH-SZ) dataset and evaluated it on five independent EEG datasets. We evaluate the systems with the following metrics: sensitivity (SEN), precision (PRE), and average and median false positive rate per hour (aFPR/h and mFPR/h). Across four adult scalp EEG and iEEG datasets, we obtained SEN of 0.617-1.00, PRE of 0.534-1.00, aFPR/h of 0.425-2.002, and mFPR/h of 0-1.003. The proposed seizure detector can detect seizures in adult EEGs and takes less than 15 s for a 30 min EEG. Hence, this system could aid clinicians in reliably identifying seizures expeditiously, allocating more time for devising proper treatment. Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Signal Processing System
Multi-Center Validation Study of Automated Classification of Pathological Slowing in Adult Scalp Electroencephalograms Via Frequency Features
10.1142/S0129065721500167INTERNATIONAL JOURNAL OF NEURAL SYSTEMS310
Time-Frequency Decomposition of Scalp Electroencephalograms Improves Deep Learning-Based Epilepsy Diagnosis
Epilepsy diagnosis based on Interictal Epileptiform Discharges (IEDs) in scalp electroencephalograms (EEGs) is laborious and often subjective. Therefore, it is necessary to build an effective IED detector and an automatic method to classify IED-free versus IED EEGs. In this study, we evaluate features that may provide reliable IED detection and EEG classification. Specifically, we investigate the IED detector based on convolutional neural network (ConvNet) with different input features (temporal, spectral, and wavelet features). We explore different ConvNet architectures and types, including 1D (one-dimensional) ConvNet, 2D (two-dimensional) ConvNet, and noise injection at various layers. We evaluate the EEG classification performance on five independent datasets. The 1D ConvNet with preprocessed full-frequency EEG signal and frequency bands (delta, theta, alpha, beta) with Gaussian additive noise at the output layer achieved the best IED detection results with a false detection rate of 0.23/min at 90% sensitivity. The EEG classification system obtained a mean EEG classification Leave-One-Institution-Out (LOIO) cross-validation (CV) balanced accuracy (BAC) of 78.1% (area under the curve (AUC) of 0.839) and Leave-One-Subject-Out (LOSO) CV BAC of 79.5% (AUC of 0.856). Since the proposed classification system only takes a few seconds to analyze a 30-min routine EEG, it may help in reducing the human effort required for epilepsy diagnosis. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Circuits and System
Improving automated diagnosis of epilepsy from EEGs beyond IEDs
Objective. Clinical diagnosis of epilepsy relies partially on identifying interictal epileptiform discharges (IEDs) in scalp electroencephalograms (EEGs). This process is expert-biased, tedious, and can delay the diagnosis procedure. Beyond automatically detecting IEDs, there are far fewer studies on automated methods to differentiate epileptic EEGs (potentially without IEDs) from normal EEGs. In addition, the diagnosis of epilepsy based on a single EEG tends to be low. Consequently, there is a strong need for automated systems for EEG interpretation. Traditionally, epilepsy diagnosis relies heavily on IEDs. However, since not all epileptic EEGs exhibit IEDs, it is essential to explore IED-independent EEG measures for epilepsy diagnosis. The main objective is to develop an automated system for detecting epileptic EEGs, both with or without IEDs. In order to detect epileptic EEGs without IEDs, it is crucial to include EEG features in the algorithm that are not directly related to IEDs. Approach. In this study, we explore the background characteristics of interictal EEG for automated and more reliable diagnosis of epilepsy. Specifically, we investigate features based on univariate temporal measures (UTMs), spectral, wavelet, Stockwell, connectivity, and graph metrics of EEGs, besides patient-related information (age and vigilance state). The evaluation is performed on a sizeable cohort of routine scalp EEGs (685 epileptic EEGs and 1229 normal EEGs) from five centers across Singapore, USA, and India. Main results. In comparison with the current literature, we obtained an improved Leave-One-Subject-Out (LOSO) cross-validation (CV) area under the curve (AUC) of 0.871 (Balanced Accuracy (BAC) of 80.9%) with a combination of three features (IED rate, and Daubechies and Morlet wavelets) for the classification of EEGs with IEDs vs. normal EEGs. The IED-independent feature UTM achieved a LOSO CV AUC of 0.809 (BAC of 74.4%). The inclusion of IED-independent features also helps to improve the EEG-level classification of epileptic EEGs with and without IEDs vs. normal EEGs, achieving an AUC of 0.822 (BAC of 77.6%) compared to 0.688 (BAC of 59.6%) for classification only based on the IED rate. Specifically, the addition of IED-independent features improved the BAC by 21% in detecting epileptic EEGs that do not contain IEDs. Significance. These results pave the way towards automated detection of epilepsy. We are one of the first to analyze epileptic EEGs without IEDs, thereby opening up an underexplored option in epilepsy diagnosis.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Signal Processing System