O cotidiano dos pais de crianças com câncer e hospitalizadas El cotidiano de los padres de los niños hospitalizados con cáncer: los retos de la enfermería The daily routine of parents of children hospitalized with cancer: nursing challenges

O estudo busca compreender o cotidiano dos pais com criança hospitalizada em uma unidade de oncologia e hematologia pediátrica de um hospital geral. Trata-se de uma investigação qualitativa, na qual foram entrevistados 13 familiares responsáveis pelos cuidados da criança. A partir da análise temática dos dados, emergiram três categorias: alterações no cotidiano familiar; principais sentimentos vivenciados pelos pais; dificuldades no tratamento e estratégias utilizadas. Conclui-se que cada família é única e apresenta dinâmicas diferentes de organização frente à experiência de câncer, no entanto, o desafio da enfermagem é articular essas diferenças e inseri-las no cuidado, amenizando o cotidiano da hospitalização.<br>El estudio trata de comprender la vida cotidiana de los padres con niños hospitalizados en una unidad de oncología pediátrica y hematología en un hospital general. Esta es una investigación cualitativa, en la que se entrevistó a 13 familiares cuidadores de los niños. A partir del análisis temático de los datos revelaron tres categorías: cambios en la vida diaria de la familia, los sentimientos principales experimentados por los padres, las dificultades en el tratamiento y las estrategias utilizadas. De ello se desprende que cada familia es única y tiene diferentes dinámicas de organización ante la experiencia del cáncer, sin embargo, el reto de la enfermería es articular estas diferencias e inserftarlas en la atención, lo que facilita la hospitalización diaria.<br>This study seeks to understand the daily lives of parents with hospitalized children in a unit of pediatric oncology and hematology at a general hospital. This is a qualitative research, in which 13 family caregivers were interviewed. Three categories resulted from the thematic analysis: changes in daily family life; main feelings experienced by parents, difficulties in treatment and strategies used. It was concluded that each family is unique and has different organization dynamics towards the cancer experience, however, the nursing challenge is to articulate these differences and include them in the care process, thus facilitating the daily hospitalization routine

Novel coumarin-pyridazine hybrids as selective MAO-B inhibitors for the Parkinson\u2019s disease therapy

The 3-pyridazinylcoumarin scaffold was previously reported as an efficient core for the discovery of reversible and selective inhibitors of MAO-B, a validated drug target for PD therapy which also plays an important role in the AD progress. Looking for its structural optimization, novel compounds of hybrid structure coumarin-pyridazine, differing in polarizability and lipophilicity properties, were synthesized and tested against the two MAO isoforms, MAO-A and MAO-B (compounds 17a-f and 18a-f). All the designed compounds selectively inhibited the MAO-B isoenzyme, exhibiting many of them IC50 values ranging from sub-micromolar to nanomolar grade and lacking neuronal toxicity. The 7-bromo-3-(6-bromopyridazin-3-yl)coumarin (18c), the most potent compound of these series (IC50 = 60 nM), was subjected to further in vivo studies in a reserpine-induced mouse PD model. The obtained results suggest a promising potential for 18c as antiparkinsonian agent. Molecular modeling studies also provided valuable information about the enzyme-drug interactions and the potential pharmacokinetic profile of the novel compounds

Female caregivers accompanying children with cancer in the hospital setting

The possibility of having a companion is a constitutional right guaranteed to children, elderly and parturients.Independently of their stage in the life cycle, having a companion is a situation socially and culturally determinedin Brazil. This is a qualitative, descriptive-exploratory and interventionist study that aims to describe and discussthe perceptions of female caregivers of children with cancer while accompanying them at the hospital. Data werecollected through a focal group with nine women, between March and May, 2007 at a teaching hospital in PortoAlegre, Rio Grande do Sul, Brazil. The thematic analyses shows the participants’ passive and kind behavior in theface of daily adversities, reflection of the power and authority conditions of the institutional objectives, so commonin health scenarios in the Brazilian reality. Emancipation could be reached through educative strategies, characterizedby information and dissemination of users’ rights as well as critical and demanding attitudes from the user whenconfronted

Religião e espiritualidade no ensino e assistência de enfermagem Religión y espiritualidad en la educación y asistencia de enfermería Religion and spirituality in education and nursing assistance

Estudo da interseção entre o discurso da enfermagem e os preceitos que albergam a religião/religiosidade e espiritualidade, e como se deu a incorporação e o reflexo desse discurso nas práticas assistenciais, no ensino e no delineamento da organização da profissão. Para revisão bibliográfica, utilizaram-se as bases de dados LILACS e BDENF, da Biblioteca Virtual de Saúde. Um total de 57 artigos completos, publicados entre 1957 e 2007, foram analisados à luz das idéias sobre " memória coletiva" , de Maurice Halbwachs. Verificou-se que há uma raiz religiosa com ramificações profundas na conformação da enfermagem brasileira. Esta configuração está tão imbricada na memória coletiva que, mesmo com a expansão de instituições que não se declaram religiosas, os pressupostos cristãos se mantêm presentes e com vitalidade.<br>Estudio de la intersección entre el discurso del oficio de enfermera y preceptos que alojan la religión/el religiosidad y el espiritualidad, y como ha dado la incorporación y a la consecuencia de este discurso en los asistencias prácticos, la educación y la delineación de la organización de la profesión. Para la revisión bibliográfica, las bases de datos LILACS y BDENF de la Biblioteca Virtual de Salud, fueron utilizadas. Un total de 57 artículos completos, publicados entre 1957 y 2007, fueron analizados a la luz de las ideas en " memoria colectiva" , de Maurice Halbwachs. Se verificó que hay una raíz religiosa con ramificaciones profundas en la conformación del oficio de enfermera brasileño. Esta configuración es tan imbricada en la memoria colectiva que, mismo con la expansión de las instituciones que non se declaran religiosas, el presupuestos cristanos se mantiene presentes y con vitalidad.<br>Intersectional study between nursing discourse and precepts which embrace religion/religiousness and spirituality, and how these were incorporated and their reflection upon nursing practice, education and the history of the organization of the profession. For bibliographic review LILACS and BDENF databases of the Electronic Health Library were used. A total of 57 full-text articles, published from 1957 to 2007, were analyzed upon the light of the ideas of Maurice Halbwachs, about " collective memory" . The results show that Brazilian nursing has a religious root with profound ramifications on its development. This configuration is so embedded in the collective memory that, even with the expansion of non-religious institutions, the Christian precepts remain present and strong