El hidrónimo prerromano Mira

The aim of this paper is to study the toponymic element Mira as it is present at old and new place names in the Iberian Peninsula, in order to establish its diffusion area and to bear out its Indo-European origins, specifically belonging to the old European hydronymy system.No disponible

La expresión del tiempo futuro en las lenguas indoeuropeas

Tesis Universidad Complutense. Madrid.Depto. de Filología ClásicaFac. de FilologíaTRUEProQuestpu

El campo semántico de la verdad en el "Edipo Rey" de Sófocles

Este trabajo intenta mostrar cómo Sófocles, una vez más, utiliza el lenguaje de una manera consciente y lo pone al servicio de la trama de la obra. Para ello, se va a analizar el uso del léxico para indicar verdad en el Edipo Rey, obra en la que dicho concepto es clave para su interpretación, y las razones que han motivado la elección de uno u otro término. El descubrimiento de la verdad, esencial en la obra, lleva aparejado el uso de un lenguaje poético acorde con la progresión de los hechos.This paper attempts to show how Sophocles once again, uses the language in a conscious way at the service of the plot of the play. To do this, the use of vocabulary to indicate truth in Oedipus Rex, a work in which the concept is central to its interpretation, will be analyzed and also the reasons for the choice of either term. The discovery of truth, essential to the work, is linked to the use of poetic language in reference to the progression of events

Implications of ICT in the socio-educational scope and social services: a college experience of innovation and teaching development with 2.0 technologies

El presente estudio emana del proyecto Innovación Docente 2.0 con Tecnologías de la Información y la Comunicación en el Espacio Europeo de Educación Superior, desarrollado en el marco de los Proyectos de Innovación y Desarrollo Docente de la Universidad Pablo de Olavide (UPO), financiado por el Vicerrectorado de Docencia y Convergencia Europea de dicha Universidad. En el artículo se describe una experiencia de innovación en enseñanza universitaria, con presentaciones educativas interactivas sobre los principales ámbitos de intervención socio-educativa del educador y el trabajador social. En la misma participaron 115 estudiantes noveles de dos titulaciones diferentes de la Facultad de Ciencias Sociales, durante el curso académico 2010-2011. Entre sus objetivos destacan: fomentar el papel activo y autónomo de los estudiantes en el proceso de construcción del conocimiento, favorecer el aprendizaje multimodal y elaborar presentaciones multimedia interactivas acerca de las ventajas e inconvenientes de las TIC en ámbitos educativos con aplicaciones de software social (Prezi y Blogs). El estudio ha corroborado que dichas estrategias metodológicas metacognitivas pueden favorecer la categorización de conceptos relevantes, así como facilitar el andamiaje socio-cognitivo y el pensamiento creativo digital del estudiantado.This study comes from the 2.0 Teaching Innovation with Information and Communication Technologies in the European Space for Higher Education, developed within the framework of the Innovation Projects and Faculty Development at the University Pablo de Olavide (UPO), funded by the Vice President for Teaching and European Convergence of the University. The article describes an innovative experience in college teaching, with interactive educational presentations on key areas of socio-educational intervention of the educator and social worker. 115 first year students coming from two different degrees from the Social Sciences Faculty took part in the research during the academic year 2010-2011. Its objectives include: promoting active and independent role of students in the process of constructing knowledge, facilitate multimodal learning and develop interactive multimedia presentations on the advantages and disadvantages of ICT in educational areas, with social software applications. The research has confirmed that such methodological strategies can promote metacognitive categorization of relevant concepts, as well as facilitate the socio-cognitive scaffolding and digital creative thinking of students.peerReviewe

Prognostic implications of preoperative systemic inflammatory markers in oral squamous cell carcinoma, and correlations with the local immune tumor microenvironment

PurposeThe aim of this study was to investigate the prognostic significance of preoperative inflammatory markers in peripheral blood of patients with oral squamous cell carcinoma (OSCC), and to establish correlations with the infiltrate of macrophages and lymphocytes in the local immune tumor microenvironment (TME).Materials and MethodsNeutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and systemic immune-inflammation index (SII) were retrospectively evaluated in a cohort of 348 OSCC patients, and correlated with overall (OS) and disease-specific survival (DSS). Immunohistochemical analysis of tumoral and stromal infiltration of CD8+, CD4+, FOXP3+ and CD20+ lymphocytes and CD68+ and CD163+ macrophages was performed in a subset of 119 OSCC patient samples, and correlations further assessed.ResultsNLR, SII, and LMR were significantly associated with a poorer OS in univariate analysis; however, only NLR remained a significant independent predictor in the multivariate analysis (HR = 1.626, p = 0.04). NLR and SII were inversely and significantly correlated with stromal infiltration of CD8+, CD4+, and CD20+ lymphocytes. Moreover, a significant correlation between LMR was also found to significantly associate with stromal infiltration of CD8+, CD4+, and CD20+ lymphocytes, stromal CD68+ and CD163+ macrophages, and also tumoral infiltration of CD4+ and CD20+ lymphocytes.ConclusionsPreoperative NLR, SII, and LMR may serve as valuable systemic markers to predict OSCC patient survival, with NLR emerging as an independent predictor of poor OS. Moreover, strong significant correlations were exclusively observed between systemic inflammatory markers and the local stromal infiltration of lymphocytes in the TME

MULTICAGE CAD-4 para la detección de adicciones conductuales: validez estructural después de la inclusión de una escala en el abuso de teléfonos inteligentes

Addictive behaviors are not limited to drugs use, but also include certain daily behaviors that can cause gratification. Their progression to more severe pathological patterns entails grave consequences for the individual, including multiple psychopathological manifestations. The early detection of this type of behavior is of concern to primary health care. Therefore, in order to detect risk at early stages, reliable and valid tools for daily practice are essential. The MULTICAGE CAD-4 questionnaire is a screening tool for simultaneously detecting addictive behaviors. This study includes a new scale for the detection of smartphone abuse. The objective is to evaluate the adequacy of its psychometric properties. A sample of 2,074 subjects that were recruited from primary care centers ofMadrid(Spain) completed the MULTICAGE CAD-4 questionnaire. A confirmatory factor analysis, using unweighted least squares method, was performed. The test showed good internal consistency both at item and scale levels. The questionnaire structure was consistent with theoretical expectations. The MULTICAGE CAD-4, including the new smartphone scale, is a robust, reliable tool with a valid structure for assessing the presence of dysfunctional or potentially addictive behaviors, and especially useful in primary health care services.Los comportamientos adictivos no se limitan al uso de drogas, sino que también incluyen ciertos comportamientos diarios que pueden causar gratificación. Su progresión a patrones patológicos más severos conlleva graves consecuencias para el individuo, incluidas múltiples manifestaciones psicopatológicas. La detección temprana de este tipo de comportamiento es de interés para la atención primaria de salud. Por lo tanto, para detectar riesgos en etapas tempranas, las herramientas confiables y válidas para la práctica diaria son esenciales. El cuestionario MULTICAGE CAD-4 es una herramienta de detección para detectar simultáneamente conductas adictivas. Este estudio incluye una nueva escala para la detección del abuso de teléfonos inteligentes. El objetivo es evaluar la adecuación de sus propiedades psicométricas. Una muestra de 2.074 sujetos reclutados en centros de atención primaria de Madrid (España) completó el cuestionario MULTICAGE CAD-4. Se realizó un análisis factorial confirmatorio, utilizando el método de mínimos cuadrados no ponderados. La prueba mostró una buena consistencia interna tanto a nivel del ítem como de las escalas. La estructura del cuestionario fue consistente con las expectativas teóricas. El MULTICAGE CAD-4, incluida la nueva escala para teléfonos inteligentes, es una herramienta robusta y confiable con una estructura válida para evaluar la presencia de comportamientos disfuncionales o potencialmente adictivos, y especialmente útil en servicios de atención primaria de salud

Hospital-based proton therapy implementation during the COVID pandemic: early clinical and research experience in a European academic institution

Introduction A rapid deploy of unexpected early impact of the COVID pandemic in Spain was described in 2020. Oncology practice was revised to facilitate decision-making regarding multimodal therapy for prevalent cancer types amenable to multidisciplinary treatment in which the radiotherapy component searched more efcient options in the setting of the COVID-19 pandemic, minimizing the risks to patients whilst aiming to guarantee cancer outcomes. Methods A novel Proton Beam Therapy (PBT), Unit activity was analyzed in the period of March 2020 to March 2021. Institutional urgent, strict and mandatory clinical care standards for early diagnosis and treatment of COVID-19 infection were stablished in the hospital following national health-authorities’ recommendations. The temporary trends of patients care and research projects proposals were registered. Results 3 out of 14 members of the professional staf involved in the PBR intra-hospital process had a positive test for COVID infection. Also, 4 out of 100 patients had positive tests before initiating PBT, and 7 out of 100 developed positive tests along the weekly mandatory special checkup performed during PBT to all patients. An update of clinical performance at the PBT Unit at CUN Madrid in the initial 500 patients treated with PBT in the period from March 2020 to November 2022 registers a distribution of 131 (26%) pediatric patients, 63 (12%) head and neck cancer and central nervous system neoplasms and 123 (24%) re-irradiation indications. In November 2022, the activity reached a plateau in terms of patients under treatment and the impact of COVID pandemic became sporadic and controlled by minor medical actions. At present, the clinical data are consistent with an academic practice prospectively (NCT05151952). Research projects and scientifc production was adapted to the pandemic evolution and its infuence upon professional time availability. Seven research projects based in public funding were activated in this period and preliminary data on molecular imaging guided proton therapy in brain tumors and post-irradiation patterns of blood biomarkers are reported. Conclusions Hospital-based PBT in European academic institutions was impacted by COVID-19 pandemic, although clinical and research activities were developed and sustained. In the post-pandemic era, the benefts of online learning will shape the future of proton therapy education

Practice-oriented solutions integrating intraoperative electron irradiation and personalized proton therapy for recurrent or unresectable cancers: Proof of concept and potential for dual FLASH effect

BackgroundOligo-recurrent disease has a consolidated evidence of long-term surviving patients due to the use of intense local cancer therapy. The latter combines real-time surgical exploration/resection with high-energy electron beam single dose of irradiation. This results in a very precise radiation dose deposit, which is an essential element of contemporary multidisciplinary individualized oncology.MethodsPatient candidates to proton therapy were evaluated in Multidisciplinary Tumor Board to consider improved treatment options based on the institutional resources and expertise. Proton therapy was delivered by a synchrotron-based pencil beam scanning technology with energy levels from 70.2 to 228.7 MeV, whereas intraoperative electrons were generated in a miniaturized linear accelerator with dose rates ranging from 22 to 36 Gy/min (at Dmax) and energies from 6 to 12 MeV.ResultsIn a period of 24 months, 327 patients were treated with proton therapy: 218 were adults, 97 had recurrent cancer, and 54 required re-irradiation. The specific radiation modalities selected in five cases included an integral strategy to optimize the local disease management by the combination of surgery, intraoperative electron boost, and external pencil beam proton therapy as components of the radiotherapy management. Recurrent cancer was present in four cases (cervix, sarcoma, melanoma, and rectum), and one patient had a primary unresectable locally advanced pancreatic adenocarcinoma. In re-irradiated patients (cervix and rectum), a tentative radical total dose was achieved by integrating beams of electrons (ranging from 10- to 20-Gy single dose) and protons (30 to 54-Gy Relative Biological Effectiveness (RBE), in 10–25 fractions).ConclusionsIndividual case solution strategies combining intraoperative electron radiation therapy and proton therapy for patients with oligo-recurrent or unresectable localized cancer are feasible. The potential of this combination can be clinically explored with electron and proton FLASH beams

¿Es posible gaminificar las aulas universitarias?

Memoria ID-0006. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2016-2017