Disks, Tori, and Cocoons: Emission and Absorption Diagnostics of AGN Environments

One of the most important problems in the study of active galaxies is understanding the detailed geometry, physics, and evolution of the central engines and their environments. The leading models involve an accretion disk and torus structure around a central dense object, thought to be a supermassive black hole. Gas found in the environment of AGN is associated with different structures: molecular accretion disks, larger scale atomic tori, ionized and neutral "cocoons" in which the nuclear regions can be embedded. All of them can be studied at radio wavelengths by various means. Here, we summarize the work that has been done to date in the radio band to characterize these structures. Much has been learned about the central few parsecs of AGN in the last few decades with contemporary instruments but the picture remains incomplete. In order to be able to define a more accurate model of this region, significant advances in sensitivity, spectral and angular resolution, and bandpass stability are required. The necessary advances will only be provided by the Square Kilometer Array and we discuss the possibilities that these dramatic improvements will open for the study of the gas in the central region of AGN.Comment: To appear in "Science with the Square Kilometer Array," eds. C. Carilli and S. Rawlings, New Astronomy Reviews (Elsevier: Amsterdam); 17 pages, 7 figures (four of them in separate gif/tif files) The full paper with high resolution images can be downloaded from http://www.astron.nl/~morganti/Papers/AGNenvironment.ps.g

Biomechanical risk factors for lower extremity stress fracture

Objectives: Stress fracture injuries disproportionately affect athletes and military service members and little is known about the modifiable biomechanical risk factors associated with these injuries. The purpose of this study was to prospectively examine the association between neuromuscular and biomechanical factors upon entry to military service and the subsequent incidence of lower-extremity stress fracture injury during four years of follow-up. Methods: We analyzed data from the JUMP-ACL cohort, an existing prospective cohort study of military cadets. JUMP-ACL conducted detailed motion analysis during a jump landing task at the initiation of each subject’s military career. We limited our analyses to the class years 2009-2013 (i.e., subjects who completed baseline testing in 2005-2008). There were 1895 subjects available for analysis. Fifty-two subjects reported a history of stress fracture at baseline and were excluded from further analysis leaving 1843 subjects. Incident lower extremity-stress fracture cases were identified through the Defense Medical Surveillance System and the Cadet Injury and Illness Tracking System during the follow-up period. The electronic medical records of each potential incident case were reviewed and each case was confirmed by an adjudication committee consisting of two sports medicine fellowship trained orthopaedic surgeons. The primary outcome of interest was the incidence rate of lower-extremity stress fracture during the follow-up period. The association between incident stress fracture and sagittal, frontal, and transverse plane hip and knee kinematics during the jump-landing task were examined at initial contact (IC), 15%(T15), 50%(T50), 85%(T85) and 100%(T100) of stance phase. Descriptive plots of all biomechanical variables along with 95% confidence intervals (CI) were generated during the stance phase of the jump landing task. Univariate and multivariable Poisson regression models were used to estimate the association between baseline biomechanical factors and the incidence rate of lower-extremity stress fracture during follow-up. Results: Overall, 94 (5.1%, 95%CI: 4.14, 6.21) subjects sustained an incident stress fracture during the follow-up period. The incidence rate for stress fracture injuries among females was nearly three times greater when compared to males (IRR=2.86, 95%CI: 1.88, 4.34, p<0.001). Compared to those with greater than 5° of knee valgus, subjects with neutral or varus knee alignment experienced incidence rates for stress fracture that were 43%-53% lower at IC (IRR=0.57, 95%CI: 0.29, 1.11, p=0.10), T50 (IRR=0.47, 95%CI=0.23, 1.00, p=0.05), and T85 (IRR=0.53, 95%CI: 0.29, 0.98, p=0.04). Subjects with greater than 5° of internal knee rotation exhibited rates for stress fracture that were 2-4 times higher at T15 (IRR=2.31, 95%CI: 1.01, 5.27, p=0.05), T50 (IRR=3.98, 95%CI: 0.99, 16.00, p=0.05), and T85 (IRR=2.31, 95%CI: 0.86, 6.23, p=0.10), when compared to those with neutral or external knee rotation alignment. Conclusion: Several potentially modifiable biomechanical factors at the time of entry into military service appear to be associated with the subsequent rate of stress fracture. It is possible that injury prevention programs targeted to address these biomechanical movement patterns may reduce the risk of stress fracture injury in athletes and military service members

Automated quantification of the landing error scoring system with a markerless motion-Capture system

Context: The Landing Error Scoring System (LESS) can be used to identify individuals with an elevated risk of lower extremity injury. The limitation of the LESS is that raters identify movement errors from video replay, which is time-consuming and, therefore, may limit its use by clinicians. A markerless motion-capture system may be capable of automating LESS scoring, thereby removing this obstacle. Objective: To determine the reliability of an automated markerless motion-capture system for scoring the LESS. Design: Cross-sectional study. Setting: United States Military Academy. Patients or Other Participants: A total of 57 healthy, physically active individuals (47 men, 10 women; age ¼ 18.6 6 0.6 years, height ¼ 174.5 6 6.7 cm, mass ¼ 75.9 6 9.2 kg). Main Outcome Measure(s): Participants completed 3 jump-landing trials that were recorded by standard video cameras and a depth camera. Their movement quality was evaluated by expert LESS raters (standard video recording) using the LESS rubric and by software that automates LESS scoring (depth-camera data). We recorded an error for a LESS item if it was present on at least 2 of 3 jump-landing trials. We calculated j statistics, prevalence- and bias-adjusted j (PABAK) statistics, and percentage agreement for each LESS item. Interrater reliability was evaluated between the 2 expert rater scores and between a consensus expert score and the markerless motion-capture system score. Results: We observed reliability between the 2 expert LESS raters (average j ¼ 0.45 6 0.35, average PABAK ¼ 0.67 6 0.34; percentage agreement ¼ 0.83 6 0.17). The markerless motion-capture system had similar reliability with consensus expert scores (average j ¼ 0.48 6 0.40, average PABAK ¼ 0.71 6 0.27; percentage agreement ¼ 0.85 6 0.14). However, reliability was poor for 5 LESS items in both LESS score comparisons. Conclusions: A markerless motion-capture system had the same level of reliability as expert LESS raters, suggesting that an automated system can accurately assess movement. Therefore, clinicians can use the markerless motion-capture system to reliably score the LESS without being limited by the time requirements of manual LESS scoring

Automated Landing Error Scoring System Performance and the Risk of Bone Stress Injury in Military Trainees

Context: Lower extremity bone stress injuries (BSIs) place a significant burden on the health and readiness of the US Armed Forces. Objective: To determine if preinjury baseline performance on an expanded and automated 22-item version of the Landing Error Scoring System (LESS-22) was associated with the incidence of BSIs in a military training population. Design: Prospective cohort study. Setting: US Military Academy at West Point, NY. Patients or Other Participants: A total of 2235 incoming cadets (510 females [22.8%]). Main Outcome Measure(s): Multivariable Poisson regression models were used to produce adjusted incidence rate ratios (IRRs) to quantify the association between preinjury LESS scores and BSI incidence rate during follow-up and were adjusted for pertinent risk factors. Risk factors were included as covariates in the final model if the 95% CI for the crude IRR did not contain 1.00. Results: A total of 54 BSIs occurred during the study period, resulting in an overall incidence rate of 0.07 BSI per 1000 person-days (95% CI = 0.05, 0.09). The mean number of exposure days was 345.4 6 61.12 (range = 3–368 days). The final model was adjusted for sex and body mass index and yielded an adjusted IRR for a LESS-22 score of 1.06 (95% CI = 1.002, 1.13; P = .04), indicating that each additional LESS error documented at baseline was associated with a 6.0% increase in the incidence rate of BSI during the follow-up period. In addition, 6 individual LESS-22 items, including 2 newly added items, were significantly associated with the BSI incidence. Conclusions: We provided evidence that performance on the expanded and automated version of the LESS was associated with the BSI incidence in a military training population. The automated LESS-22 may be a scalable solution for screening military training populations for BSI risk

Differences in Lower Extremity Movement Quality by Level of Sport Specialization in Cadets Entering a United States Service Academy

Background: Sport specialization in youth athletes is associated with increased risk for musculoskeletal injury; however, little is known about whether sport specialization is associated with lower extremity movement quality. The purpose of this study was to examine differences in lower extremity movement quality by level of sport specialization in US Service Academy cadets. Hypothesis: Cadets who report an increased level of sport specialization would have a lower level of movement quality than those who are less specialized. Study Design: Cross-sectional analysis from an ongoing prospective cohort study. Level of Evidence: Level 3. Methods: Cadets completed the Landing Error Scoring System (LESS) and a baseline questionnaire evaluating level of sport specialization during high school. Data were analyzed using separate 1-way analysis of variance models. Results: Among all participants (n = 1950), 1045 (53.6%) reported low sport specialization, 600 (30.8%) reported moderate sport specialization, and 305 (15.6%) reported high sport specialization at the time of data collection during the first week. Ages ranged from 17 to 23 years. Men (1491) and women (459) reported comparable specialization levels (P = 0.45). There were no statistically significant differences in lower extremity movement quality by level of specialization for all subjects combined (P = 0.15) or when only men were included in the analyses (P = 0.69). However, there were statistically significant differences in movement quality by level of specialization in women (P = 0.02). Moderately specialized women had the best movement quality (mean, 4.63; SD, 2.21) followed by those with high specialization (mean, 4.90; SD, 2.08) and those with low levels of specialization (mean, 5.23; SD, 2.07). Conclusion: Women reporting moderate sport specialization had improved movement quality and significantly better LESS scores compared to those with high/low specialization. Clinical Relevance: Athletes, especially women, should be encouraged to avoid early sport specialization to optimize movement quality, which may affect injury risk

The Effects of an Injury Prevention Program on Landing Biomechanics over Time

Background: Knowledge is limited regarding how long improvements in biomechanics remain after completion of a lower extremity injury prevention program. Purpose: To evaluate the effects of an injury prevention program on movement technique and peak vertical ground-reaction forces (VGRF) over time compared with a standard warm-up (SWU) program. Study Design: Controlled laboratory study. Methods: A total of 1104 incoming freshmen (age range, 17-22 years) at a military academy in the United States volunteered to participate. Participants were cluster-randomized by military company to either the Dynamic Integrated Movement Enhancement (DIME) injury prevention program or SWU. A random subsample of participants completed a standardized jump-landing task at each time point: immediately before the intervention (PRE), immediately after (POST), and 2 (POST2M), 4 (POST4M), 6 (POST6M), and 8 months (POST8M) after the intervention. VGRF data collected during the jump-landing task were normalized to body weight (%BW). The Landing Error Scoring System (LESS) was used to evaluate movement technique during the jump landing. The change scores (δ) for each variable (LESS, VGRF) between the group's average value at PRE and each time point were calculated. Separate univariate analyses of variance were performed to evaluate group differences. Results: The results showed a greater decrease in mean (±SD) VGRF in the DIME group compared with the SWU group at all retention time points: POST2M (SWU [δ%BW], -0.13 ± 0.82; DIME, -0.62 ± 0.91; P =.001), POST4M (SWU, -0.15 ± 0.98; DIME,-0.46 ± 0.64; P =.04), POST6M (SWU, -0.04 ± 0.96; DIME, -0.53 ± 0.83; P =.004), and POST8M (SWU, 0.38 ± 0.95; DIME, -0.11 ± 0.98; P =.003), but there was not a significant improvement in the DIME group between PRE and POST8M (δ%BW, -0.11 ± 0.98). No group differences in δ LESS were observed. Conclusion: The study findings demonstrated that an injury prevention program performed as a warm-up can reduce vertical ground-reaction forces compared with a standard warm-up but a maintenance program is likely necessary in order for continued benefit. Clinical Relevance: Injury prevention programs may need to be performed constantly, or at least every sport season, in order for participants to maintain the protective effects against injury

Landing Error Scoring System (LESS) Items are Associated with the Incidence Rate of Lower Extremity Stress Fracture

Objectives: Lower-extremity stress fracture injuries are a major cause of morbidity in physically active populations. The ability to efficiently screen for modifiable risk factors associated with injury is critical in developing and implementing effective injury prevention programs. The purpose of this study was to determine if baseline Landing Error Scoring System (LESS) scores were associated with the incidence rate of lower-extremity stress fracture during four years of follow-up. Methods: To accomplish this objective we conducted a prospective cohort study at a US Service Academy. A total of 1772 eligible subjects with complete baseline data and no history of lower-extremity stress fracture were included in this study. At baseline we conducted motion analysis during a jump landing task using the LESS. Incident lower-extremity stress fracture cases were identified during the four year follow-up period using the injury surveillance systems at our institution. The primary outcome of interest was the incidence rate of lower-extremity stress fracture during follow-up. The electronic medical records of each potential incident case were reviewed and case status was determined by an adjudication committee consisting of two sports medicine fellowship-trained orthopaedic surgeons who were blinded to baseline LESS data. The association between baseline LESS scores and the incidence rate of lower-extremity stress fracture was examined for total LESS score and for each individual LESS item. Univariate and multivariable Poisson regression models were used to estimate the association between baseline LESS scores and the incidence rate of lower-extremity stress fracture during follow-up. Results: During the follow-up period, 94 incident lower-extremity stress fractures were documented in the study cohort and the cumulative incidence of stress fracture was 5.3% (95%CI: 4.3%, 6.5%). In univariate analyses total LESS score at baseline was associated with the incidence rate of lower-extremity stress fracture during follow-up. For every additional movement error documented at baseline there was a 15% increase in the incidence rate of lower-extremity stress fracture during follow-up (IRR=1.15; 95%CI: 1.02, 1.31, p=0.025). Based on univariate analyses, several individual LESS items at baseline were also associated with the incidence rate of stress fracture during follow-up. Ankle flexion at initial contact (p=0.055), stance width at initial contact (p=0.026), asymmetrical landing at initial contact (p=0.003), trunk flexion at initial contact (p=0.036), and overall impression (p=0.021) were significantly associated with the incidence rate of stress fracture. In multivariable analyses controlling for sex and year of entry into the cohort, subjects who consistently landed flat-footed or heel-to-toe were 2.33 times (IRR=2.33; 95%CI: 1.36, 3.97, p=0.002) more likely to sustain a lower-extremity stress fracture during follow-up. Similarly, subjects who consistently demonstrated asymmetric landing at initial contact were 2.53 times (IRR=2.53; 95%CI: 1.34, 4.74, p=0.004) more likely to sustain a stress fracture during follow-up. Conclusion: These data suggest that specific LESS items may be predictive of lower-extremity stress fracture risk and may be helpful in injury screening and prevention

Effect of a lower extremity preventive training program on physical performance scores in military recruits

Exercise-based preventive training programs are designed to improve movement patterns associated with lower extremity injury risk; however, the impact of these programs on general physical fitness has not been evaluated. The purpose of this study was to compare fitness scores between participants in a preventive training program and a control group. One thousand sixty-eight freshmen from a U.S. Service Academy were cluster-randomized into either the intervention or control group during 6 weeks of summer training. The intervention group performed a preventive training program, specifically the Dynamic Integrated Movement Enhancement (DIME), which is designed to improve lower extremity movement patterns. The control group performed the Army Preparation Drill (PD), a warm-up designed to prepare soldiers for training. Main outcome measures were the Army Physical Fitness Test (APFT) raw and scaled (for age and sex) scores. Independent t tests were used to assess between-group differences. Multivariable logistic regression models were used to control for the influence of confounding variables. Dynamic Integrated Movement Enhancement group participants completed the APFT 2-mile run 20 seconds faster compared with the PD group (p, 0.001), which corresponded with significantly higher scaled scores (p, 0.001). Army Physical Fitness Test push-up scores were significantly higher in the DIME group (p = 0.041), but there were no significant differences in APFT sit-up scores. The DIME group had significantly higher total APFT scores compared with the PD group (p, 0.001). Similar results were observed in multivariable models after controlling for sex and body mass index (BMI). Committing time to the implementation of a preventive training program does not appear to negatively affect fitness test scores

Association Between Landing Error Scoring System (LESS) Items and the Incidence Rate of Lower Extremity Stress Fracture

Background: Lower extremity stress fracture injuries are a major cause of morbidity in physically active populations. The ability to screen for modifiable risk factors associated with injury is critical in developing injury-prevention programs.Purpose:To determine if baseline Landing Error Scoring System (LESS) scores are associated with the incidence rate of lower extremity stress fracture.Study Design:Cohort study; Level of evidence, 2. Methods: A total of 1772 participants with no history of lower extremity stress fracture were included. At preinjury baseline, the authors conducted a lower extremity movement assessment during a jump-landing task using the LESS. Incident lower extremity stress fractures were identified during a 4-year follow-up period. Potential incident cases were reviewed by 2 sports medicine fellowship-trained orthopaedic surgeons blinded to baseline LESS data. Univariate and multivariable Poisson regression models were used to estimate the association between baseline total LESS scores, individual LESS items, and the incidence rate ratio (IRR) of lower extremity stress fracture. Results: A total of 94 incident lower extremity stress fractures were documented, for a 5.3% (95% CI, 4.3%-6.5%) cumulative incidence. The overall LESS score was associated with the incidence rate of lower extremity stress fracture. For every additional movement error documented at baseline, there was a 15% increase in the incidence rate of lower extremity stress fracture (IRR, 1.15 [95% CI, 1.02-1.31]; P = .025). In univariate analyses, ankle flexion, stance width, asymmetrical landing, and trunk flexion at initial contact, in addition to overall impression, were associated with the incidence rate of stress fracture. After controlling for sex and year of entry into the study cohort, participants who consistently landed flat-footed or heel-to-toe were 2.33 times (95% CI, 1.36-3.97; P = .002) more likely to sustain a lower extremity stress fracture. Similarly, participants who consistently demonstrated asymmetric landing at initial contact were 2.53 times (95% CI, 1.34-4.74; P = .004) more likely to sustain a stress fracture. Conclusion: Components of the LESS may be associated with increased lower extremity stress fracture risk and may be helpful in efficiently assessing high-risk lower extremity biomechanics in large groups

Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability

Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized. Human CASPR2 autoantibodies, when injected into mice, were peripherally restricted and resulted in mechanical pain-related hypersensitivity in the absence of neural injury. We therefore investigated the mechanism by which CASPR2 modulates nociceptive function. Mice lacking CASPR2 (Cntnap2(-/-)) demonstrated enhanced pain-related hypersensitivity to noxious mechanical stimuli, heat, and algogens. Both primary afferent excitability and subsequent nociceptive transmission within the dorsal horn were increased in Cntnap2(-/-) mice. Either immune or genetic-mediated ablation of CASPR2 enhanced the excitability of DRG neurons in a cell-autonomous fashion through regulation of Kv1 channel expression at the soma membrane. This is the first example of passive transfer of an autoimmune peripheral neuropathic pain disorder and demonstrates that CASPR2 has a key role in regulating cell-intrinsic dorsal root ganglion (DRG) neuron excitability