PHARMACOLOGICAL SCREENING FOR POTENCY OF ANTIOBESITY ON FIVE PLANTS BASED ON ETHNOPHARMACOLOGICAL USE

ABSTRACTObjective: The objective of this research was to screening potency of anti-obesity effect and antioxidant activity from Sapindus rarak Pulp., Punicagranatum Leaves, Jasminllum sambac Flos., Tamarindus indica Pulp., and Senna alexandrina Leaves.Methods: This study was performed through in-vitro method to determine the potency of anti-obesity, such as its ability to inhibit pancreatic lipaseactivity and radical-scavenging activity against free radicals like 1,1-diphenyl-2-picrylhydrazyl to determine the potency of these plants as antioxidant.Results: The 50% inhibitory concentration of pancreatic lipase activity inhibitory and antioxidant activity consecutively, P. granatum Leaves(20.64 ppm; 77.89 ppm), J. sambac Flos. (53.46 ppm; 127.95 ppm), T. indica Pulp. (62.02 ppm; 159.16 ppm), S. alexandrina Leaves (94.69 ppm;142.28 ppm), and S. rarak Pulp. (796.32 ppm; 147.56 ppm).Conclusion: P. granatum Leaves showed the best potency of anti-obesity compared to other plants based on its ability to inhibit pancreatic lipaseactivity and antioxidant activity.Keywords: Anti-obesity, Pancreatic lipase activity, Antioxidant