Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

Background: Some evidence suggests that cannabidiol (CBD) has potential to help alleviate HIV symptoms due to its antioxidant and anti-inflammatory properties. Here we examined acute CBD effects on various behaviors and the endocannabinoid system in HIV Tat transgenic mice. Methods: Tat transgenic mice (female/male) were injected with CBD (3, 10, 30 mg/kg) and assessed for antinociception, activity, coordination, anxiety-like behavior, and recognition memory. Brains were taken to quantify endocannabinoids, cannabinoid receptors, and cannabinoid catabolic enzymes. Additionally, CBD and metabolite 7-hydroxy-CBD were quantified in the plasma and cortex. Results: Tat decreased supraspinal-related nociception and locomotion. CBD and sex had little to no effects on any of the behavioral measures. For the endocannabinoid system male sex was associated with elevated concentration of the proinflammatory metabolite arachidonic acid in various CNS regions, including the cerebellum that also showed higher FAAH expression levels for Tat(+) males. GPR55 expression levels in the striatum and cerebellum were higher for females compared to males. CBD metabolism was altered by sex and Tat expression. Conclusion: Findings indicate that acute CBD effects are not altered by HIV Tat, and acute CBD has no to minimal effects on behavior and the endocannabinoid system

Downloading digital video games: predictors, moderators and consequences

Purpose – The purpose of this paper is to investigate how personal and social factors influence attitudes towards downloading pirated games from the internet. It also examines the moderators between attitudes and intention to download pirated digital video games. Design/methodology/approach – The research was conducted using convenience samples in a large university in Western Australia. The data were analysed mostly through regression models. Findings – Self-efficacy, affect and moral judgement have significant influences upon attitudes towards downloading pirated games from the internet. Conversely, habits, facilitating conditions and social factors do not have significant influences upon attitudes towards downloading pirated games from the internet. In addition, attitudes towards downloading pirated digital video games from the internet have a significant influence upon the intention to download pirated digital video games from the internet. It is also found that the level of internet usage, the level of internet time spent and the internet speed do not moderate the relationship between attitudes and intention to download pirated games from the internet. Research limitations/implications – The major limitation is the use of a convenience sample. Therefore, future research should replicate and extend this study by using more valid random samples. In addition, qualitative approach, field experiment and foolspeed campaign analysis need to be considered to gain a better understanding of why internet users indulge in games piracy.Practical implications – Authorities should create awareness campaigns about digital video games piracy to alert the public about the risk of being caught and the consequence of unethical behaviour. Managers, marketers and policy makers should collaborate to combat piracy to prevent illegal downloading of free pirated games in the future. Originality/value – The paper assesses the impact of six antecedents and the attitudes towards downloading pirated digital video games from the internet that will lead to the intention to download pirated digital video games from the Internet

Developing a peace education curriculum for Vietnamese primary schools : a case study of participatory action research in cross-cultural design

In 2003, the International Conflict Resolution Centre at the University of Melbourne, Australia, produced a primary school teaching manual for UNESCO Vietnam. The finished manual included lesson plans and materials for a five year, 50 lesson peace education course. The manual is one of the first examples of a systematic core national curriculum in peace education worldwide. Development of the Teaching Manual posed a number of challenges including differences in language, culture, government and education system. To meet these challenges, a participatory action research approach was central in the project’s development and curriculum design. This case study is offered as a model for effective crosscultural curriculum development of peace education materials. In particular, the use of games and reflective materials and the use of UNESCO’s peace keys are outlined as innovative outcomes of the project

Nutrientes foliares de espécies arbóreas de três estádios sucessionais de floresta ombrófila densa no sul do Brasil Leaf nutrient content of tree species from three successional stages of tropical rain forest in south Brazil

As concentrações de macro e micronutrientes foliares de espécies arbóreas foram avaliadas em três estádios sucessionais (inicial, intermediário e avançado) de uma floresta ombrófila densa das terras baixas, no litoral do Estado do Paraná, crescendo sobre solo arenoso e oligotrófico. Dentre as espécies arbóreas mais importantes de cada estádio sucessional (quatro iniciais; oito intermediárias; 11 avançadas), coletou-se folhas maduras de cinco diferentes indivíduos de cada estádio sucessional para a análise química dos seguintes elementos: N, P, K, Ca, Mg, C, Zn, Fe, Cu e Mn. As espécies do estádio inicial possuem as menores concentrações médias foliares de N, P, K, Zn, Fe e a maior concentração de Mg e estas concentrações são estatisticamente diferentes (p <0,05), quando comparadas com os valores médios dos demais estádios. Nos estádios intermediário e avançado, as concentrações médias de N, Ca e Mg, assim como os micronutrientes estão dentro dos valores esperados para florestas tropicais. As concentrações médias de K, nos estádios inicial e intermediário, e as concentrações médias de P, em todos os estádios, encontram-se abaixo dos valores reportados para as florestas tropicais. A relação C/N é alta (>25:1), apesar da tendência de diminuir à medida que avança a sucessão. O aumento da concentração da maioria dos nutrientes foliares analisados ao longo do gradiente sucessional está associado, possivelmente, com o incremento do acúmulo da serapilheira sobre o solo, o que proporciona ciclagem de nutrientes mais intensa e maiores concentrações de nutrientes no solo.<br>We investigated the leaf nutrient content of trees species from three distinct successional stages (early, intermediate, late) of a lowland rain forest located near the coast of Paraná State, Brazil. This forest grows on sandy soil with low nutrient content. We collected mature leaves from five different individuals of each sucessional stages of the most important tree species of each successional stage (four of the early; eight of the intermediate and 11 of the late stages) for chemical analysis of following elements: N, P, K, Ca, Mg, C, Zn, Fe, Cu e Mn. The species from early sucessional stage have lower contents of N, P, K, Zn, Fe, and higher contents of Mg. These concentrations are statistically different (p <0,05) when compared to mean values of the other stages. For the intermediate and late successional stages, the average nutrient concentrations of N, Ca, Mg and micronutrients are within the range of values expected for tropical forests. Foliar K concentration, from early and intermediate successional stages, and foliar P concentration, for all successional stages, are below the reported range of values for tropical forests. The C/N ratio is high (>25:1), despite of the tendency to decrease as succession advances. The increment of concentration of the most studied foliar nutrients along the successional gradient is probably related to the accumulation of litter above the soil that provides a more adequate environment for efficient nutrient cycling and higher nutrient concentration in the soil