Do host genetic traits in the bacterial sensing system play a role in the development of Chlamydia trachomatis-associated tubal pathology in subfertile women?

BACKGROUND: In women, Chlamydia (C.) trachomatis upper genital tract infection can cause distal tubal damage and occlusion, increasing the risk of tubal factor subfertility and ectopic pregnancy. Variations, like single nucleotide polymorphisms (SNPs), in immunologically important host genes are assumed to play a role in the course and outcome of a C. trachomatis infection. We studied whether genetic traits (carrying multiple SNPs in different genes) in the bacterial sensing system are associated with an aberrant immune response and subsequently with tubal pathology following a C. trachomatis infection. The genes studied all encode for pattern recognition receptors (PRRs) involved in sensing bacterial components. METHODS: Of 227 subfertile women, serum was available for C. trachomatis IgG antibody testing and genotyping (common versus rare allele) of the PRR genes TLR9, TLR4, CD14 and CARD15/NOD2. In all women, a laparoscopy was performed to assess the grade of tubal pathology. Tubal pathology was defined as extensive peri-adnexal adhesions and/or distal occlusion of at least one tube. RESULTS: Following a C. trachomatis infection (i.e. C. trachomatis IgG positive), subfertile women carrying two or more SNPs in C. trachomatis PRR genes were at increased risk of tubal pathology compared to women carrying less than two SNPs (73% vs 33% risk). The differences were not statistically significant (P = 0.15), but a trend was observed. CONCLUSION: Carrying multiple SNPs in C. trachomatis PRR genes tends to result in an aberrant immune response and a higher risk of tubal pathology following a C. trachomatis infection. Larger studies are needed to confirm our preliminary findings

Tratamiento estadístico de datos granulométricos. Aplicación a la formación « Utrillas » del extremo occidental de la cordillera Ibérica y borde del Sistema Central

En el presente trabajo se estudia la distribución de frecuencias para las fracciones clastométricas de los sedimentos de Ja facies "Utrillas" (ciclo superior del Cretácico), calculándose los parámetros estadísticos para 67 muestras de sedimentos. Un análisis factorial sobre los parámetros calculados y otro sobre los pesos retenidos en los tamices completa el estudio estadístico

Sedimentos dolomíticos para-actuales: la "Tierra Blanca" de La Roda (Albacete)

Se estudian unos materiales dolomíticos para-actuales intentando reconstruir su génesis a partir de datos de campo y del empleo de técnicas de laboratorio: Análisis químico, difracción de rayos X, análisis térmico diferencial y microscopía (petrográfica y electrónica). El análisis litoestratigráfico, mineralógico y geoquímico nos ha permitido establecer un origen continental lacustre y proponer un modelo del proceso evolutivo de los materiales, que podría ser aplicado a la génesis de dolomías continentales en condiciones geomorfológicas y climáticas similares a !as estudiadas por nosotros

Determinación de la corrosión en un Sistema CO2-H2S-Salmuera-Acero api 5L grado X65, utilizando un Electrodo de Cilindro Rotatorio

By using Linear Polarization Resistance, Electrochemical Impedance Spectroscopy and Tafel Extrapolation, the corrosion resistance of a carbon steel API 5L X65 degree was evaluated in the Rotating Cylinder Electrode (RCE), submerged in a 3%p NaCl solution deareated and 40 ºC at atmospheric pressure. The dynamics of tests was controlled by the RCE with speeds between 0 and 3 m/s, and varying the H2S/CO2 molar relation from 0 to 8.34x10-3. The mass transference coefficients of H+, HS- and HCO3- and the shear stress near the interface metal-liquid interface were determined, by using applicable experimental correlations for the geometry of RCE. Finally, correlations were determined which showed the relationship between the corrosion rate and the mass transference coefficients and shear stress, with the fluid flow of this multiphase system and the H2S/CO2 molar ratio.Por medio de las técnicas Resistencia a la Polarización Lineal, Espectroscopia de Impedancia Electroquímica y Extrapolación de Tafel, se evaluó la corrosión del acero API 5L grado X65 con un Electrodo de Cilindro Rotatorio (ECR), en una solución desaireada al 3% en peso de NaCl a 40 ºC y a presión atmosférica. La dinámica de las pruebas fue controlada por el ECR con velocidades entre 0 y 3m/s, variando la concentración de la relación molar H2S/CO2, desde 0 a 8.34x10-3. Se calcularon los coeficientes de transferencia de masa de las especies H+, HS- y HCO3- y los esfuerzos de corte cerca de la interfase metal–líquido, empleando correlaciones experimentales aplicables para la geometría del ECR. Finalmente, se determinó la relación entre la velocidad de corrosión, los coeficientes de transferencia de masa y los esfuerzos de corte, con la velocidad de flujo de este sistema multifásico y la relación molar H2S/CO2

Slow Epidemic of Lymphogranuloma Venereum L2b Strain

We traced the Chlamydia trachomatis L2b variant in Amsterdam and San Francisco. All recent lymphogranuloma venereum cases in Amsterdam were caused by the L2b variant. This variant was also present in the 1980s in San Francisco. Thus, the current "outbreak" is most likely a slowly evolving epidemic

Evaluation of CAM-CHEM VSL model performance during Southtrac campaign

In the framework of the SouthTRAC Campaign (Transport and Composition of the Southern Hemisphere Upper Troposphere and Lower Stratosphere) based on Rio Grande, Argentina, a local research group from CONICET (Argentine National Research Council) joined the German consortium maintaining the HALO research aircraft (High-Altitude and LOng-range aircraft) to help with the flight planning and evaluation of the chemical composition of the upper troposphere and lower stratosphere within the ozone hole periphery. The SouthTRAC aircraft campaign was carried out in two phases which took place in September and November 2019, respectively. With the purpose of providing additional information of the atmospheric composition of brominated Very Short-Lived (VSLBr) species and compare with HALO observations during the transfer and campaign flights, a CAM-Chem (Community Atmosphere Model with Chemistry) global chemistry-climate simulation was conducted. The model setup used in the halogenated CAM-Chem simulation had a 1° x 1.25° lat-lon resolution, 56 hybrid vertical levels from the surface to the middle stratosphere and considered assimilated meteorology from MERRA, including an explicit treatment of VSLBr sources and chemistry. Model output of VSLBr, long-lived bromine and chlorine (LLBr and LLCl) species and ozone mixing ratios, as well as the main inorganic halogen reactive and reservoir species and gas/heterogeneous phase reaction rates affecting lowermost stratospheric ozone were analyzed in horizontal domains and vertical cross-sections across each flightpath. The model performance with respect to the HALO observations has a general good agreement, presenting better results for mid latitudes (between 30º S and 50º S) than for southern latitudes (>50º S). In particular, CAM-Chem timeseries consistently reproduced the spatio-temporal variation of the main VSLBr species (CH2Br2 and CHBr3), including the sharp variations observed across the tropopause. For both VSLBr as well as for LLCl compounds such as CFC-12, the Pearson correlation coefficient r obtained during each of the flights ranged between 0.7 and 0.9, while the Normalized Mean Bias (NMB) was smaller than 8% for almost every flight. Regarding LLBr CH3Br, the correlation with the aircraft observations is high (r>0.9) but the inter-hemispheric variability during transfer flights is not fully captured. For Ozone, the model presents mid to high correlation with respect to measures (0.5Fil: Berná Peña, Lucas Luciano. Universidad Tecnológica Nacional. Facultad Regional de Mendoza; ArgentinaFil: Lopez Noreña, Ana Isabel. Universidad Tecnológica Nacional. Facultad Regional de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Puliafito, Salvador Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina. Universidad Tecnológica Nacional. Facultad Regional de Mendoza; ArgentinaFil: Barreras, Javier Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Engel, Andreas. Goethe Universitat Frankfurt; AlemaniaFil: Jesswein, Markus. Goethe Universitat Frankfurt; AlemaniaFil: Cuevas, Carlos A.. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Saiz Lopez, Alfonso. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Fernandez, Rafael Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaEGU General Assembly 2021AustriaEuropean Geosciences Unio

Recognition memory deficits in mild cognitive impairment

There is no agreement on the pattern of recognition memory deficits characteristic of patients diagnosed with mild cognitive impairment (Mel). Whereas lower performance in recollection is the hallmark of Mel, there is a strong controversy about possible deficits in familiarity estimates when using recognition memory tasks. The aim of this research is to shed Iight on the pattern of responding in recollection and familiarity in MCl. Five groups of participants were tested. The main participant samples were those formed by two Mel groups differing in age and an Alzheimer's disease group (AD), which were compared with two control groups, Whereas one of the control groups served to assess the performance of the MeI and AD people, the other one, composed of young healthy participants, served the purpose of evaluating the adequacy of the experimental tasks used in the evaluation of the different components of recognition memory. We used an associative recognition task as a direct index of recollection and a choice task on a pair of stimuli, one of which was perceptually similar to those studied in the associative recognition phase, as an index of familiarity. Our results indicate that recollection decreases with age and neurological status, and familiarity remains stable in the elderly control sample but it is deficient in Me!. This research shows that a unique encoding situation generated deficits in recollective and familiarity mechanisms in mild cognitive impaired individuals, providing evidence for the existence of deficits in both retrieval processes in recognition memory in a MeI stage

Integrated assessment of the impact of climate and land use changes on groundwater quantity and quality in the Mancha Oriental system (Spain)

[EN] Climate and land use change (global change) impacts on groundwater systems cannot be studied in isolation. Land use and land cover (LULC) changes have a great impact on the water cycle and contaminant production and transport. Groundwater flow and storage are changing in response not only to climatic changes but also to human impacts on land uses and demands, which will alter the hydrologic cycle and subsequently impact the quantity and quality of regional water systems. Predicting groundwater recharge and discharge conditions under future climate and land use changes is essential for integrated water management and adaptation. In the Mancha Oriental system (MOS), one of the largest groundwater bodies in Spain, the transformation from dry to irrigated lands during the last decades has led to a significant drop of the groundwater table, with the consequent effect on stream-aquifer interaction in the connected Jucar River. Understanding the spatial and temporal distribution of water quantity and water quality is essential for a proper management of the system. On the one hand, streamflow depletion is compromising the dependent ecosystems and the supply to the downstream demands, provoking a complex management issue. On the other hand, the intense use of fertilizer in agriculture is leading to locally high groundwater nitrate concentrations. In this paper we analyze the potential impacts of climate and land use change in the system by using an integrated modeling framework that consists in sequentially coupling a watershed agriculturally based hydrological model (Soil and Water Assessment Tool, SWAT) with a groundwater flow model developed in MODFLOW, and with a nitrate mass-transport model in MT3DMS. SWAT model outputs (mainly groundwater recharge and pumping, considering new irrigation needs under changing evapotranspiration (ET) and precipitation) are used as MODFLOW inputs to simulate changes in groundwater flow and storage and impacts on stream-aquifer interaction. SWAT and MODFLOW outputs (nitrate loads from SWAT, groundwater velocity field from MODFLOW) are used as MT3DMS inputs for assessing the fate and transport of nitrate leached from the topsoil. Three climate change scenarios have been considered, corresponding to three different general circulation models (GCMs) for emission scenario A1B that covers the control period, and short-, medium-and long-term future periods. A multi-temporal analysis of LULC change was carried out, helped by the study of historical trends (from remote-sensing images) and key driving forces to explain LULC transitions. Markov chains and European scenarios and projections were used to quantify trends in the future. The cellular automata technique was applied for stochastic modeling future LULC maps. Simulated values of river discharge, crop yields, groundwater levels and nitrate concentrations fit well to the observed ones. The results show the response of groundwater quantity and quality (nitrate pollution) to climate and land use changes, with decreasing groundwater recharge and an increase in nitrate concentrations. The sequential modeling chain has been proven to be a valuable assessment tool for supporting the development of sustainable management strategies.This study was partially funded by the EU FP7 GENESIS project (no. 226.536) on groundwater systems, the Plan Nacional de I+D+I 2008-2011 of the Ministry of Science and Innovation of Spain (projects CGL2009-13238-C02-01/02 on climate change impacts and adaptation), and the IMPADAPT project (CGL2013-48424-C2-1-R) with Spanish MINECO (Ministerio de Economia y Competitividad) and Feder funds. 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