Star formation characteristics of galaxies hosting AGN

We present an analysis of the ultra-violet (UV) observations of two Seyfert type active galactic nuclei (AGN), namely NGC$~$4051 and NGC$~$4151. These observations aimed at studying the star formation in the hosts of these AGN were carried out with the ultra-violet imaging telescope on board AstroSat in far-UV. A total of 193 and 328 star-forming regions (SF) were identified using SExtractor in NGC$~$4051 and NGC$~$4151, respectively. Using aperture photometry of the identified SF regions, we estimated the star formation rates (SFRs). We found NGC$~$4051 to have the lowest SFR with a median value of 3.16 $\times$ 10$^{-5}$ M$_{\odot}$ yr$^{-1}$ while for NGC$~$4151, we found a median SFR of 0.012 M$_{\odot}$ yr$^{-1}$.Comment: Comments are welcome. Accepted for the 3rd BINA Proceeding

Minus salt goat skin preservation: Extreme chloride reduction in tannery wastewater

Content: Animal skins, a byproduct of the meat industry is the basic raw materials for the tanning industry. Just after flaying, animal skins have to preserve protecting it from microbiological destruction. Globally, sodium chloride is mostly used as popular preserving agents for the animal skins. It preserves the skin by its dehydrating ability. Nevertheless, sodium chloride is cost-effective, available, and easy to apply but the method suffers greatly in terms of environmental context. To reduce the pollution load, especially chloride in soaking operation several works have been carried out to preserve animal skins with various agents. This study is intended to preserve the goat skin with Sphagneticola trilobata leaf paste without sodium chloride for reducing the chloride in the soaking liquor. The plant has antimicrobial activity, widely distributed tropical and subtropical regions. The anticipated preservation method was assessed monitoring different parameters e.g., shrinkage temperature, hair slip, putrefaction, odour, moisture content, extractable nitrogen, and bacterial count on fresh (raw), 1st, 4th, 7th, 14th, 21st and 28th day in comparison to the conventional wet salting method. The physical properties of the processed leathers e.g., tensile strength, percentage of elongation, and ball burst of the crust leathers were fulfilled the required values. The chemical parameters like chloride, total dissolved solids (TDS), biochemical oxygen demand (BOD), and chemical oxygen demand (COD) of soaking liquor were investigated. The proposed preservation method was reduced pollution loads: chloride, TDS, BOD, and COD in soaking operation by 98.04%, 92.9%, 90.2% and 85.5%, respectively. The scanning electron microscope (SEM) photographs of both the present and conventional preservation methods processed crust leathers revealed similar texture and quality to each other. The anticipated preservation method could be a sustainable option to preserve goat skin, which could reduce the pollution loads during leather processing. Take-Away: 1. Sphagneticola trilobata leaf paste preserved goat skin up to 28 days 2. Reduction of chloride and TDS were 98.04% and 92.9% in soaking liquor 3. Lessening of BOD and COD were 90.2% and 85.5% in soaking liquo

A Hierarchical Framework for explaining the Cosmic Ray Spectrum using Diffusive Shock Acceleration

The hypothesis that the entire cosmic ray spectrum, from $\lesssim1\,{\rm GeV}$ to $\gtrsim100\,{\rm EeV}$ energy, can be accounted for by diffusive shock acceleration on increasingly large scales is critically examined. Specifically, it is conjectured that Galactic cosmic rays, up to $\sim3\,{\rm PeV}$, are mostly produced by local supernova remnants, from which they escape upstream. These cosmic rays initiate a powerful magnetocentrifugal wind, removing disk mass and angular momentum before passing through the Galactic Wind Termination Shock at a radius $\sim200\,{\rm kpc}$, where they can be re-accelerated to account for observed cosmic rays up to $\sim30\,{\rm PeV}$. The cosmic rays transmitted downstream from more powerful termination shocks associated with other galaxies can be further accelerated at Intergalactic Accretion Shocks to the highest energies observed. In this interpretation, the highest rigidity observed particles are protons; the highest energy particles are heavy nuclei, such as iron. A universal "bootstrap" prescription, coupling the energy density of the magnetic turbulence to that of the resonant cosmic rays, is proposed, initially for the highest energy particles escaping far ahead of the shock front and then scattering, successively, lower energy particles downstream. Observable implications of this general scheme relate to the spectrum, composition and sky distribution of Ultra-High-Energy Cosmic Rays, the extragalactic radio background, the Galactic halo magnetic field and Pevatrons.Comment: accepted for publication on Proceedings of Science for the 38th International Cosmic Ray Conference (ICRC2023

Sorption comparison of trivalent chromium on various Ficus carica charcoal from tannery wastewater

Content: In this study, equipped charcoal of Ficus carica without impregnation, impregnated with potassium hydroxide (KOH), zinc chloride (ZnCl2) and phosphoric acid (H3PO4) was used for sorption comparison of trivalent chromium from tannery wastewater. The equipped charcoal is characterized before and after used by Fourier transforms infrared spectroscopy (FT-IR). The quantitative elemental analysis is performed of the charcoal using PGT Energy dispersive X-ray spectrometry (EDX). The trivalent chromium sorption efficacy of charcoal was examined investigating charcoal dose, contact time, and relative pH parameters. Batch sorption test revealed that Ficus carica charcoal without impregnation had the maximum sorption capacity of trivalent chromium as depicted Fig. 1a. At the same conditions, trivalent chromium sorption on the Ficus carica charcoal without impregnation, impregnated with potassium hydroxide, zinc chloride and phosphoric acid was 98.9%, 98.8%, 8.9 and 2.5%, respectively. It is noticeable that without impregnation charcoal has a higher sorption capacity. Conversely, impregnation with chemical required cost involvement, time-consuming, long process time, and safe. Fig.1b depicts a shift in the peak intensity which indicated the change of frequency in the functional groups of the charcoal due to chromium adsorption. It indicates various responsible functional groups for the removal of trivalent chromium through Ficus carica charcoal. The trivalent chromium removal efficiency with the Ficus carica charcoal without impregnation was achieved 98.9%. The study could be helpful to design the sorption of trivalent chromium from the tannery wastewater in-house prior to discharge. Take-Away: 1. Without impregnation, Ficus carica charcoal has a better trivalent chromium sorption capacity 2. Trivalent chromium sorption capacity was 98.9

Star formation in the dwarf Seyfert galaxy NGC 4395: Evidence for both AGN and SNe feedback?

We present a detailed multi-wavelength study of star formation in the dwarf galaxy NGC 4395 which hosts an active galactic nucleus (AGN). From our observations with the Ultra-Violet Imaging Telescope, we have compiled a catalogue of 284 star forming (SF) regions, out of which we could detect 120 SF regions in H$\alpha$ observations. Across the entire galaxy, we found the extinction corrected star formation rate (SFR) in the far ultra-violet (FUV) to range from 2.0 $\times$ 10$^{-5}$ M$_\odot$yr$^{-1}$ to 1.5 $\times$ 10$^{-2}$ M$_\odot$yr$^{-1}$ with a median of 3.0 $\times$ 10$^{-4}$ M$_\odot$yr$^{-1}$ and age to lie in the range of $\sim$ 1 to 98 Myr with a median of 14 Myr. In H$\alpha$ we found the SFR to range from 7.2 $\times$ 10$^{-6}$ M$_\odot$yr$^{-1}$ to 2.7 $\times$ 10$^{-2}$ M$_\odot$yr$^{-1}$ with a median of 1.7 $\times$ 10$^{-4}$ M$_\odot$yr$^{-1}$ and age to lie between 3 to 6 Myr with a median of 5 Myr. The stellar ages derived from H$\alpha$ show a gradual decline with galactocentric distance. We found three SF regions close to the center of NGC~4395 with high SFR both from H$\alpha$ and UV which could be attributed to feedback effects from the AGN. We also found six other SF regions in one of the spiral arms having higher SFR. These are very close to supernovae remnants which could have enhanced the SFR locally. We obtained a specific SFR (SFR per unit mass) for the whole galaxy 4.64 $\times$ 10$^{-10}$ yr$^{-1}$.Comment: 10 pages, 11 figures, Accepted for publication in Ap

Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice

BACKGROUND:Radiation-induced gastrointestinal syndrome (RIGS) results from a combination of direct cytocidal effects on intestinal crypt and endothelial cells and subsequent loss of the mucosal barrier, resulting in electrolyte imbalance, diarrhea, weight loss, infection and mortality. Because R-spondin1 (Rspo1) acts as a mitogenic factor for intestinal stem cells, we hypothesized that systemic administration of Rspo1 would amplify the intestinal crypt cells and accelerate the regeneration of the irradiated intestine, thereby, ameliorating RIGS. METHODS AND FINDINGS:Male C57Bl/6 mice received recombinant adenovirus expressing human R-spondin1 (AdRspo1) or E.coli Lacz (AdLacz), 1-3 days before whole body irradiation (WBI) or abdominal irradiation (AIR). Post-irradiation survival was assessed by Kaplan Meier analysis. RIGS was assessed by histological examination of intestine after hematoxilin and eosin staining, immunohistochemical staining of BrdU incorporation, Lgr5 and beta-catenin expression and TUNEL staining. The xylose absorption test (XAT) was performed to evaluate the functional integrity of the intestinal mucosal barrier. In order to examine the effect of R-spondin1 on tumor growth, AdRspo1 and AdLacZ was administered in the animals having palpable tumor and then exposed to AIR. There was a significant increase in survival in AdRspo1 cohorts compared to AdLacZ (p<0.003) controls, following WBI (10.4 Gy). Significant delay in tumor growth was observed after AIR in both cohorts AdRspo1 and AdLacZ but AdRspo1 treated animals showed improved survival compared to AdLacZ. Histological analysis and XAT demonstrated significant structural and functional regeneration of the intestine in irradiated animals following AdRspo1 treatment. Immunohistochemical analysis demonstrated an increase in Lgr5+ve crypt cells and the translocation of beta-catenin from the cytosol to nucleus and upregulation of beta-catenin target genes in AdRspo1-treated mice, as compared to AdLacz-treated mice. CONCLUSION:Rspo1 promoted radioprotection against RIGS and improved survival of mice exposed to WBI. The mechanism was likely related to induction of the Wnt-beta-catenin pathway and promotion of intestinal stem cell regeneration. Rspo1 has protective effect only on normal intestinal tissue but not in tumors after AIR and thereby may increase the therapeutic ratio of chemoradiation therapy in patients undergoing abdominal irradiation for GI malignancies

Reducing Down(stream)time: Pretraining Molecular GNNs using Heterogeneous AI Accelerators

The demonstrated success of transfer learning has popularized approaches that involve pretraining models from massive data sources and subsequent finetuning towards a specific task. While such approaches have become the norm in fields such as natural language processing, implementation and evaluation of transfer learning approaches for chemistry are in the early stages. In this work, we demonstrate finetuning for downstream tasks on a graph neural network (GNN) trained over a molecular database containing 2.7 million water clusters. The use of Graphcore IPUs as an AI accelerator for training molecular GNNs reduces training time from a reported 2.7 days on 0.5M clusters to 1.2 hours on 2.7M clusters. Finetuning the pretrained model for downstream tasks of molecular dynamics and transfer to a different potential energy surface took only 8.3 hours and 28 minutes, respectively, on a single GPU.Comment: Machine Learning and the Physical Sciences Workshop at the 36th conference on Neural Information Processing Systems (NeurIPS

Evidence for low power radio jet-ISM interaction at 10 parsec in the dwarf AGN host NGC 4395

Black hole driven outflows in galaxies hosting active galactic nuclei (AGN) may interact with their interstellar medium (ISM) affecting star formation. Such feedback processes, reminiscent of those seen in massive galaxies, have been reported recently in some dwarf galaxies. However, such studies have usually been on kiloparsec and larger scales and our knowledge on the smallest spatial scales to which these feedback processes can operate is unclear. Here we demonstrate radio jet$-$ISM interaction on the scale of an asymmetric triple radio structure of $\sim$ 10 parsec size in NGC 4395. This triple radio structure is seen in the 15 GHz continuum image and the two asymmetric jet-like structures are situated on either side of the radio core that coincides with the optical {\it Gaia} position. The high resolution radio image and the extended [OIII]$\lambda$5007 emission, indicative of an outflow, are spatially coincident and are consistent with the interpretation of a low power radio jet interacting with the ISM. Modelling of the spectral lines using {\tt MAPPINGS}, and estimation of temperature using optical integral field spectroscopic data suggest shock ionization of the gas. The continuum emission at 237 GHz, though weak, was found to spatially coincide with the AGN. However, the CO(2$-$1) line emission was found to be displaced by around 20 parsec northward of the AGN core. The spatial coincidence of molecular H$_2$$\lambda$2.4085 along the jet direction, the morphology of ionised [OIII]$\lambda$5007 and displacement of the CO(2$-$1) emission argues for conditions less favourable for star formation in the central $\sim$ 10 parsec region.Comment: 20 pages, 18 figures, accepted for the publication of The Astrophysical Journa

Bone Marrow Stromal Cell Transplantation Mitigates Radiation-Induced Gastrointestinal Syndrome in Mice

Nuclear accidents and terrorism presents a serious threat for mass casualty. While bone-marrow transplantation might mitigate hematopoietic syndrome, currently there are no approved medical countermeasures to alleviate radiation-induced gastrointestinal syndrome (RIGS), resulting from direct cytocidal effects on intestinal stem cells (ISC) and crypt stromal cells. We examined whether bone marrow-derived adherent stromal cell transplantation (BMSCT) could restitute irradiated intestinal stem cells niche and mitigate radiation-induced gastrointestinal syndrome.Autologous bone marrow was cultured in mesenchymal basal medium and adherent cells were harvested for transplantation to C57Bl6 mice, 24 and 72 hours after lethal whole body irradiation (10.4 Gy) or abdominal irradiation (16-20 Gy) in a single fraction. Mesenchymal, endothelial and myeloid population were characterized by flow cytometry. Intestinal crypt regeneration and absorptive function was assessed by histopathology and xylose absorption assay, respectively. In contrast to 100% mortality in irradiated controls, BMSCT mitigated RIGS and rescued mice from radiation lethality after 18 Gy of abdominal irradiation or 10.4 Gy whole body irradiation with 100% survival (p<0.0007 and p<0.0009 respectively) beyond 25 days. Transplantation of enriched myeloid and non-myeloid fractions failed to improve survival. BMASCT induced ISC regeneration, restitution of the ISC niche and xylose absorption. Serum levels of intestinal radioprotective factors, such as, R-Spondin1, KGF, PDGF and FGF2, and anti-inflammatory cytokines were elevated, while inflammatory cytokines were down regulated.Mitigation of lethal intestinal injury, following high doses of irradiation, can be achieved by intravenous transplantation of marrow-derived stromal cells, including mesenchymal, endothelial and macrophage cell population. BMASCT increases blood levels of intestinal growth factors and induces regeneration of the irradiated host ISC niche, thus providing a platform to discover potential radiation mitigators and protectors for acute radiation syndromes and chemo-radiation therapy of abdominal malignancies