17 research outputs found

    Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014

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    The relationship between the severity of dysmenorrhea and the level of physical activity among 16-25 year old female students of the different colleges in De La Salle Health Sciences Institute

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    The study employed a cross-sectional design and multi-stage sampling was utilized. The study population was divided into clusters depending on the college or department they were under. Individual subjects were selected by random sampling. Two (2) self-administered questionnaire using standardized International Physical Activity Questionnaire was used to assess the independent variable, level of physical activity. On the other hand, the severity of dysmenorrhea was assessed using the Wong-Baker Faces Pain Rating Scale. Chi-square was used for data analysis. The study concluded that the study did not support the hypothesis that there was a relationship between the level of physical activity and severity of dysmenorrhea among 16-25 year old female students from the different colleges of De La Salle Health Sciences Institute. However, based on this study, there was an increasing prevalence of dysmenorrhea among female students, thus, the need for future studies in helping to reduce this growing problem may be beneficial for female students, as well as non-students, within the reproductive age group

    Defining a ‘golden window' period and relevance of systemic inflammatory response syndrome (SIRS) in acute on chronic liver failure (ACLF) a tool for intervention and improved survival

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    Conference Theme: New Horizons from East to west in HepatologyTopic 1 - Acute on Chronic Liver Failure: no. 1948This journal suppl. entitled: Conference Abstracts: 24th Annual Conference of APASL, March 12-15, 2015, Istanbul, TurkeyBACKGROUND AND AIMS: Systemic Inflammatory Response Syndrome (SIRS) is an early marker of sepsis and ongoing inflammation. Sepsis is the most common cause of mortality. The aim is to study the natural course of SIRS and sepsis in a hospitalized ACLF cohort without SIRS, sepsis at baseline and to define a window period for possible intervention. METHODS: Consecutive hospitalized patient of ACLF were prospectively evaluated for the development of SIRS/sepsis and associated complications till 90 days follow up, liver transplant or death. All patients received standard medical care, sepsis screening was done for initial 15 days, followed by ‘on suspicion’ screening. RESULTS: 201 patients with median age 46 yr (IQR = 38–45), male (91 %) and majority of ethanol (47 %) etiology. New onset SIRS, sepsis and septic shock at the end of first week were (77.6, 10 and 1 %) respectively. The time to development of SIRS, sepsis were 6.18 ± 1.7 and 7 days (IQR 4–7) respectively. Rate of development or resolution of SIRS 11–12 % per day. Development of SIRS associated with procalcitonin positivity (P = 0.05). Increasing no of organ failure (0, 3, 4) associated with higher incidence of SIRS (24, 87.5 and 100 % respectively, P\0.05). SIRS at D7 leads to a median survival (12 vs. 29 weeks), first week mortality (23 % vs. none, P\0.005) and 90 days mortality of (51.9 % vs. 37.8 %, P = 0.12). CONCLUSION: SIRS and its dynamicity is an important predictor of early sepsis, organ failure and survival in ACLF. Prompt use of prophylactic antibiotics with onset SIRS and rigorous septic screen during in the Golden window could improve outcome
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