Glioblastoma and the significance of MGMT gene methylation

In this research Glioblastoma has been studied as one of the most common brain tumors and a short review of the available therapeutic methods have presented including surgery, radiotherapy, chemotherapy and particularly adjuvant chemotherapy with temozolomide, as the most effective developed treatment. Moreover, MGMT gene promoter methylation has been introduced as an important predictive factor of treatment response to temozolamide. The different mechanisms of methylation and the availableliterature on its association with patient survival and disease recurrence have been summarized. Taken together, Glioblastoma is a tumor in which the MGMT gene expression can potentially deliver the highest amount of data in comparison to other tumors; as almost every related study has emphasized on the direct association between MGMT methylation and patient survival. Regarding this debate, the pseudoprogression pattern in Glioblastoma patients and the laboratory methods studying MGMT gene methylation have been examined. At the end of this review, the obstacles to its development have been briefly mentioned

Incorporating user values into housing design through indirect user participation using MEC-QFD model

This study aims to incorporate user values into housing design. Incorporating user values is essential for developing quality housing. Data was gathered in three stages using the Means-End Chain and Quality Function Deployment models. To identify the factors that create values, the MEC model was conducted using soft laddering interviews with 15 apartment occupants in Bushehr, Iran. Next, weight assessments were done for value creators. With data from the first phase, a hard laddering questionnaire survey of MEC was created and distributed among 150 respondents. Nine architects developed design strategies in a focus group discussion to establish the House of Quality of QFD based on responses. The developed strategies involved four main categories including Building Organizational Emphasis, Interior Design Emphasis, Exterior Design Emphasis, and Indoor Environmental Emphasis. The combination of MEC and QFD facilitates indirect user participation and fulfills person environment congruence