2 research outputs found
High-grade renal cell carcinoma with emperipolesis: Clinicopathological, immunohistochemical and molecular-genetic analysis of 14 cases
Emperipolesis has recently been described as
a constant feature of “biphasic squamoid” papillary renal
cell carcinoma (BPRCC). We also noticed this in some
high-grade (HG) RCC, which promoted the present
study to estimate the incidence of emperipolesis in RCCs
and to describe them in further detail.
14 cases of HGRCC showing emperipolesis were
retrieved from our registry. Microscopic examination of
filed slides was supplemented with immunohistochemical and molecular-genetic analyses using paraffin
embedded tissue.
12 of 14 patients were males with a mean age of
58.6 years (range 41-72 years). Tumor size ranged from
6-16.5 cm (mean of 8.8 cm). Follow up data were
available for 8/14 patients (range 0.5-10 years).
Metastases were documented in 6 cases. All tumors
showed solid-alveolar growth patterns with focal
pseudopapillary features, and were composed of large
cells with bizarre nuclei and eosinophilic rhabdoid-like
cytoplasm. Emperipolesis was a constant and prominent
feature in large bizarre cells. All cases were positive for
OSCAR, CANH 9, vimentin, cyclin D1, INI-1, and
myoD1, while negative for melanocytic markers, CK 7,
myoglobin, cathepsin K, and TFE3. VHL gene
abnormalities were found in 6/9 analyzable cases, of
which 2 demonstrated polysomy of chromosomes 7, 17.
Emperipolesis is a rare histomorphologic feature
which can be seen not only in BPRCCs but also in
highgrade CCRCCs. All RCC cases with prominent
emperipolesis fulfilled both morphologic and
immunohistochemical diagnostic criteria of high-grade
CCRCC. The majority of patients with available follow
up information developed metastases